DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alrm and lingo4b

DIOPT Version :9

Sequence 1:	NP_651393.1	Gene:	alrm / 43074	FlyBaseID:	FBgn0039332	Length:	471	Species:	Drosophila melanogaster
Sequence 2:	NP_001082850.1	Gene:	lingo4b / 559074	ZFINID:	ZDB-GENE-091214-3	Length:	604	Species:	Danio rerio

Alignment Length:	426	Identity:	110/426 - (25%)
Similarity:	180/426 - (42%)	Gaps:	78/426 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 VLWWLLSLQVVLILPPSYHLATPSSGSGQLRRLWLQDHCSA--------GICTNVVIGRSDYVIL 59
            :|.|.|:|...       .|..|...|  ..|..|:.:||:        |:.||.
Zfish    15 LLLWCLNLSAA-------DLPCPQRCS--CSRDPLEVNCSSRHLTAVPEGLPTNA---------- 60

  Fly    60 SQAPIGGTTMLTFLN---SSIAKIPHLLFDTFPDLQVLRMENCSLETFEKPQFEGASNLMSLFLG 121
            .:..:.|..:.|...   ||::|:..|      ||.    ||. :...|...|:|..||..|.:.
Zfish    61 KRLDLSGNQLKTLARRQFSSLSKLEDL------DLS----ENI-ISMIEVETFQGLKNLRYLRIK 114

  Fly   122 YNRLKDIPKNIFLGADNLATLHLQGNQLKQLGNHSFHALKEVKELSLAENQLEQISLGVFSGMRK 186
            .||||.:|..:|.|..||..|.:..|::....:::|..:..:::|...||.|..||...|.|::.
Zfish   115 NNRLKILPVGVFSGLSNLRRLDISENEILVFLDYTFRDMINLQQLDAGENDLVFISQRAFVGLQA 179

  Fly   187 LMDLNLAGNRLDALPRGVFDRNLNLTKLNLARNRFTAFESELLKLQPVFTQLDIS---GNIFQEL 248
            |.:||:..:.|.::|.....:..:||||.|.:                   |.||   .|.|:.|
Zfish   180 LKELNVDRSNLTSIPTEALSQLQSLTKLRLRK-------------------LTISVLPNNAFRRL 225

  Fly   249 -------TLNFTMLDVAIAHSCDLRRLTVYGVIHELDLHNNSLREMPHIPL--AANVSSLDLSHN 304
                   .|:::.|::..::|.....||.      |.|.|.:|..:|:.||  .|.:..||||:|
Zfish   226 HQLRTLQILHWSSLEMLNSNSLVGLNLTT------LVLTNCNLSAIPYSPLRHLAYLQYLDLSYN 284

  Fly   305 PLGNLQGNPLRRFTSLLRLNLSATGAHELPEGLFKKQSHLQMLDISGNSIYSLKITIFDSLKALQ 369
            |:.::|||.|.....|..|:|.......:..|.|:..|..::|::|.|.:.:|:.:.|.|:..||
Zfish   285 PITSIQGNLLGDLLRLQELHLVGGNLLRIEPGAFRGLSRFRLLNVSSNRLSTLEESAFHSVGNLQ 349

  Fly   370 YFYFQQNNWNCDFLQLLMSSFVKRKDISFMEDITAP 405
            .....:|...||...|.:....:|.|....:...:|
Zfish   350 TLRLDRNPLACDCRLLWVMRRRRRLDFDGRQPTCSP 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alrm	NP_651393.1	LRR_RI	84..354	CDD:238064	78/281 (28%)
		LRR_8	91..149	CDD:290566	20/57 (35%)
		leucine-rich repeat	91..114	CDD:275380	6/22 (27%)
		leucine-rich repeat	115..138	CDD:275380	9/22 (41%)
		LRR_8	138..197	CDD:290566	16/58 (28%)
		leucine-rich repeat	139..162	CDD:275380	4/22 (18%)
		leucine-rich repeat	163..186	CDD:275380	8/22 (36%)
		LRR_8	185..243	CDD:290566	13/60 (22%)
		leucine-rich repeat	187..210	CDD:275380	5/22 (23%)
		leucine-rich repeat	211..283	CDD:275380	19/81 (23%)
		leucine-rich repeat	284..319	CDD:275380	15/36 (42%)
		LRR_8	318..377	CDD:290566	14/58 (24%)
		leucine-rich repeat	320..343	CDD:275380	5/22 (23%)
		leucine-rich repeat	344..365	CDD:275380	5/20 (25%)
lingo4b	NP_001082850.1	LRRNT	28..61	CDD:214470	9/44 (20%)
		leucine-rich repeat	41..62	CDD:275380	5/30 (17%)
		LRR	<56..304	CDD:227223	78/293 (27%)
		leucine-rich repeat	63..83	CDD:275380	4/19 (21%)
		leucine-rich repeat	84..107	CDD:275380	8/33 (24%)
		leucine-rich repeat	108..131	CDD:275380	9/22 (41%)
		leucine-rich repeat	132..155	CDD:275380	4/22 (18%)
		leucine-rich repeat	156..179	CDD:275380	8/22 (36%)
		leucine-rich repeat	180..203	CDD:275380	5/22 (23%)
		leucine-rich repeat	204..251	CDD:275380	14/65 (22%)
		leucine-rich repeat	228..250	CDD:275380	3/21 (14%)
		leucine-rich repeat	252..275	CDD:275380	9/28 (32%)
		leucine-rich repeat	276..297	CDD:275380	10/20 (50%)
		LRR_8	299..358	CDD:316378	15/58 (26%)
		leucine-rich repeat	300..321	CDD:275380	5/20 (25%)
		leucine-rich repeat	324..344	CDD:275380	5/19 (26%)
		I-set	415..498	CDD:254352
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910