DRSC/TRiP Functional Genomics Resources

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Protein Alignment alrm and cDIP

DIOPT Version :9

Sequence 1:NP_651393.1 Gene:alrm / 43074 FlyBaseID:FBgn0039332 Length:471 Species:Drosophila melanogaster
Sequence 2:NP_650951.1 Gene:cDIP / 42512 FlyBaseID:FBgn0038865 Length:554 Species:Drosophila melanogaster


Alignment Length:461 Identity:134/461 - (29%)
Similarity:208/461 - (45%) Gaps:63/461 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    66 GTT----------MLTFLNSSIAKIPHLLFDTFPDLQVLRMENCSLETFEKPQFE-GASNLMSLF 119
            |||          .|.|.|.:....|..||.|. ::..|.|..|.:.......|. ||..|:.|.
  Fly    84 GTTYEVGDEEHSRTLIFENCTFTNFPLRLFYTL-EVSELDMRGCGIRFIYWENFSIGADKLVILL 147

  Fly   120 LGYNRLKDIPKNIFLGADNLATLHLQGNQLKQLGNHSFHALKEVKELSLAENQLEQISLGVFSGM 184
            |..|.::.:|...|.||.||..:.|..|:|.:|...:|..|.:::.|.|.||:||.::..||:|:
  Fly   148 LSDNHIEVLPTKTFRGAGNLEFIFLNRNKLGKLQAGAFDNLLKLQYLDLTENRLEALAADVFAGL 212

  Fly   185 RKLMDLNLAGNRLDALPRGVFDRNLNLTKLNLARNRFT-----AFESELLKLQPVFTQLDISGN- 243
            :.|..:.||||:|..:...:|..|.:|..:.:..||..     ||.|.....|..:  :|:|.| 
  Fly   213 KSLRHVGLAGNQLTTIESDLFAHNPDLLSVAMQNNRLREVGEYAFRSRGRHHQMQY--VDLSNNP 275

  Fly   244 --IFQELTLNFTMLDVAIAHSCDLRRLTVYGVIHELDLHNNSLRE--------MPHIPLAAN--- 295
              :...|.:|.|.|   .|.:|.|.|:.:||.:..:||.:|.:||        :.|:.|..|   
  Fly   276 ELVVLLLNINATNL---TARNCSLDRVNLYGSVTNVDLSDNRVRELYFPASEALEHLVLRNNSLV 337

  Fly   296 ----------VSSLDLSHNP-LGNLQGNPLRRFTSLLRLNLSATGAHELPEGLFKKQSHLQMLDI 349
                      :..||::.|| ||.|...  .|...|..|.|..||..|||....:...:||.|||
  Fly   338 QLASLSRVPRLRHLDVADNPNLGQLPDG--WRTPHLEMLVLRNTGQMELPLEALQGMQNLQKLDI 400

  Fly   350 SGNSIYSLKITIFDSLKALQYFYFQQNNWNCDFLQLLMSSFVKRKDISFMEDITAPELVDDYVDG 414
            |||::..:..:.|.:|..|.:||...|||||..|:.:|...::...|::..|...|:...:|..|
  Fly   401 SGNNLTEIDPSAFPTLTQLTHFYIHGNNWNCFSLRNIMDVLIRANGIAYTVDNYDPDFPGEYFHG 465

  Fly   415 IACWY-----------ESDKQSKKCESG---GSDAAMELSVVRNEIKTFTELVEKKFVKVYRMLE 465
            |||.|           .|.:.|...||.   .|....|:..:|:|:|...:..:.||..::..|.
  Fly   466 IACMYRLPEKEGVDSSSSSEISASVESSPITSSSDPSEVDKLRDELKAVVQHFDSKFDLIFSKLA 530

  Fly   466 EMKMKL 471
            ::..::
  Fly   531 QLNEQI 536

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
alrmNP_651393.1 LRR_RI 84..354 CDD:238064 94/300 (31%)
LRR_8 91..149 CDD:290566 18/58 (31%)
leucine-rich repeat 91..114 CDD:275380 6/23 (26%)
leucine-rich repeat 115..138 CDD:275380 8/22 (36%)
LRR_8 138..197 CDD:290566 22/58 (38%)
leucine-rich repeat 139..162 CDD:275380 7/22 (32%)
leucine-rich repeat 163..186 CDD:275380 9/22 (41%)
LRR_8 185..243 CDD:290566 17/62 (27%)
leucine-rich repeat 187..210 CDD:275380 8/22 (36%)
leucine-rich repeat 211..283 CDD:275380 22/79 (28%)
leucine-rich repeat 284..319 CDD:275380 13/56 (23%)
LRR_8 318..377 CDD:290566 21/58 (36%)
leucine-rich repeat 320..343 CDD:275380 8/22 (36%)
leucine-rich repeat 344..365 CDD:275380 9/20 (45%)
cDIPNP_650951.1 leucine-rich repeat 118..142 CDD:275380 6/23 (26%)
LRR_RI 143..407 CDD:238064 85/270 (31%)
leucine-rich repeat 143..166 CDD:275380 8/22 (36%)
LRR_8 166..225 CDD:290566 22/58 (38%)
leucine-rich repeat 167..190 CDD:275380 7/22 (32%)
leucine-rich repeat 191..214 CDD:275380 9/22 (41%)
leucine-rich repeat 215..238 CDD:275380 8/22 (36%)
leucine-rich repeat 239..265 CDD:275380 6/25 (24%)
leucine-rich repeat 266..325 CDD:275380 18/63 (29%)
LRR_8 304..357 CDD:290566 10/52 (19%)
leucine-rich repeat 326..347 CDD:275380 3/20 (15%)
leucine-rich repeat 348..394 CDD:275380 16/47 (34%)
LRR_8 369..428 CDD:290566 21/58 (36%)
LRR_4 393..433 CDD:289563 18/39 (46%)
leucine-rich repeat 395..418 CDD:275380 10/22 (45%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG25852
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0007563
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR45617
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
44.020

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