DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alrm and caps

DIOPT Version :9

Sequence 1:	NP_651393.1	Gene:	alrm / 43074	FlyBaseID:	FBgn0039332	Length:	471	Species:	Drosophila melanogaster
Sequence 2:	NP_001303391.1	Gene:	caps / 39493	FlyBaseID:	FBgn0023095	Length:	811	Species:	Drosophila melanogaster

Alignment Length:	421	Identity:	111/421 - (26%)
Similarity:	168/421 - (39%)	Gaps:	78/421 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 VVLILPPSYHLATPSSGSGQLRRLWLQDHCSAGICTNVVIGRSDYVI-LSQAPIG-----GTTML 70
            :.:.|.|  ||       ||...|.|   |   :|..:|:......: |:..|.|     .|.|:
  Fly     7 ITMSLAP--HL-------GQAFSLCL---C---LCLCLVLATLPVALGLANCPNGCECDDDTLMV 56

  Fly    71 TFLNSSIAKIPHLLFDTFPDLQVLRMENCSLETFEKP-QFEGASNLMSLFLGYNRLKDIPKNIFL 134
            .....::..:|..|   .|.:|.|.::|..|:|.:.. ||  .:.|..|.|.:|.:..||:..|.
  Fly    57 NCGEGTLDVLPIAL---NPAIQRLVIKNNKLKTIDSSMQF--YAQLTFLDLSFNDMLTIPERSFA 116

  Fly   135 GADNLATLHLQGNQLKQLGNHSFHALKEVKELSLAENQLEQISLGVFSGMRKLMDLNLAGNRLDA 199
            ....|..|||..|::.|:.|.:|..|..:..|:|..|.:.::....||.|.||.:|||..||:..
  Fly   117 YHAKLQELHLDHNKIGQVSNKTFLGLSTISVLNLRGNLIAELEYRTFSPMVKLAELNLGQNRISH 181

  Fly   200 LPRGVFDRNLNLTKLNLARNRFTAFESELL-----KLQPVF----TQLDISGNIFQELTLNFTML 255
            :.....|...||..|.|..|..|....||.     .|..::    :.:.|.|..||:|. ..|.|
  Fly   182 IDPHALDGLDNLRVLYLDDNTLTTVPGELTFQALHSLAELYLGTNSFMTIPGGAFQDLK-GLTRL 245

  Fly   256 DVAIAHSCDLRRLTVYGVI--HELDLHNNSLREMPHIPLAA-----NVSSLDLSHNPLGNLQGNP 313
            |:..|...::....:.|::  ..|||.:|.|   |.||.||     .:..|::..|....:...
  Fly   246 DLRGAGLHNISGDALKGLVSLRFLDLSDNRL---PAIPTAAFQRLGRLEQLNIGQNDFEVISSG- 306

  Fly   314 LRRFTSLLRL-NLSATGAHEL---PEGLFKKQSHLQMLDISGN-----------------SIYSL 357
              .|:.|..| :|..|||..|   ..|.|...::|:.|::|.|                 |...|
  Fly   307 --AFSGLRELRHLELTGAQRLRRVESGAFSGNTNLEHLNLSSNKQLNELSSIALGGLPHLSTVVL 369

  Fly   358 KITIFDSLKA-------LQYFYFQQNNWNCD 381
            |.....||..       ||.....:|.:.||
  Fly   370 KANQLSSLDEGLVPWADLQTLDLSENPFECD 400

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alrm	NP_651393.1	LRR_RI	84..354	CDD:238064	84/307 (27%)
		LRR_8	91..149	CDD:290566	19/58 (33%)
		leucine-rich repeat	91..114	CDD:275380	7/23 (30%)
		leucine-rich repeat	115..138	CDD:275380	7/22 (32%)
		LRR_8	138..197	CDD:290566	21/58 (36%)
		leucine-rich repeat	139..162	CDD:275380	9/22 (41%)
		leucine-rich repeat	163..186	CDD:275380	6/22 (27%)
		LRR_8	185..243	CDD:290566	18/66 (27%)
		leucine-rich repeat	187..210	CDD:275380	7/22 (32%)
		leucine-rich repeat	211..283	CDD:275380	21/82 (26%)
		leucine-rich repeat	284..319	CDD:275380	9/39 (23%)
		LRR_8	318..377	CDD:290566	20/86 (23%)
		leucine-rich repeat	320..343	CDD:275380	9/26 (35%)
		leucine-rich repeat	344..365	CDD:275380	7/37 (19%)
caps	NP_001303391.1	leucine-rich repeat	75..96	CDD:275380	7/22 (32%)
		LRR_8	96..155	CDD:290566	19/58 (33%)
		leucine-rich repeat	97..120	CDD:275380	7/22 (32%)
		leucine-rich repeat	121..144	CDD:275380	9/22 (41%)
		LRR_8	143..201	CDD:290566	18/57 (32%)
		leucine-rich repeat	145..168	CDD:275380	6/22 (27%)
		LRR_RI	147..397	CDD:238064	67/256 (26%)
		leucine-rich repeat	169..192	CDD:275380	7/22 (32%)
		leucine-rich repeat	193..217	CDD:275380	7/23 (30%)
		LRR_8	217..276	CDD:290566	15/59 (25%)
		leucine-rich repeat	218..241	CDD:275380	6/23 (26%)
		leucine-rich repeat	242..265	CDD:275380	5/22 (23%)
		LRR_8	265..321	CDD:290566	16/61 (26%)
		leucine-rich repeat	266..289	CDD:275380	10/25 (40%)
		leucine-rich repeat	290..313	CDD:275380	4/25 (16%)
		LRR_8	312..374	CDD:290566	15/61 (25%)
		leucine-rich repeat	314..335	CDD:275380	8/20 (40%)
		leucine-rich repeat	339..363	CDD:275380	4/23 (17%)
		LRRCT	395..445	CDD:214507	3/6 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45617
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010