DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alrm and CG6749

DIOPT Version :9

Sequence 1:	NP_651393.1	Gene:	alrm / 43074	FlyBaseID:	FBgn0039332	Length:	471	Species:	Drosophila melanogaster
Sequence 2:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster

Alignment Length:	392	Identity:	107/392 - (27%)
Similarity:	167/392 - (42%)	Gaps:	81/392 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 FDTFPDLQVLRMENCSLETFEKPQFEGASNLMSLFLGYNRLKDIPKNIFLGADNLATLHLQGNQL 149
            |...|:|:.|.:..|.|.......|...|.|..:...:|:::.:.::.|.....|...:...|.|
  Fly   100 FSILPNLRQLNLSGCGLVDIRGNHFAPESALQRIDFSHNQMELLDRDFFGNLRKLIYANFSHNAL 164

  Fly   150 KQ------------------LGNHSFHALKEVKELSLAENQLEQISLGVFSGMRKLMDLNLAGNR 196
            ||                  |.|.:|....:::||.|.:|||.|:.:..|.|:..|::|.|:|||
  Fly   165 KQCDLPHMPLLNRLELGHNRLVNATFGVCPQLQELILNDNQLIQLDVNAFRGLHGLLELQLSGNR 229

  Fly   197 LDALPRGVFDRNLNLTKLNLARNR--------FTAFESELLKLQPVFTQLDISGNIFQELTLN-- 251
            |.::....|.....|.||||::|.        |.|.::.:|.||    |||:|||..:.|..|
  Fly   230 LSSIGLETFQPLAQLRKLNLSQNALDALRPNVFGAVQNFVLHLQ----QLDLSGNRIRLLFDNQF 290

  Fly   252 -----FTMLDV--------AIAHSCDLRRLTVYGVIHELDLHNNSLREMPHIPLAA--NVSSLDL 301
                 ..||||        :.||...|      |.:.:|.|..|::.|:.....||  |:.:|||
  Fly   291 RVLARLQMLDVSRNSIASLSPAHFVGL------GSLRKLYLQYNAILEIKPATFAALLNLDTLDL 349

  Fly   302 SHNPLGNLQ-----GNPLRRFTSLLRLNLSATGAHELPEGLFKKQSHLQMLDISGNSIYSLKITI 361
            |:|.|..|:     ||.|.|   :.||||:......|....|.....|:.|.:..|.:.||.:.:
  Fly   350 SYNNLEFLEEQIFGGNTLPR---MRRLNLNGNRMKHLHPLAFSSLPFLEYLKLGHNELKSLDVRM 411

  Fly   362 FDSLKALQYFYFQQN---NWNCDFLQLLMS-----------SFVKRKDISFMEDITAPELVDDYV 412
            |..::.||..:...|   ..|.|.|:.|.|           :|:.:.::||      |.|....:
  Fly   412 FAPMRRLQKLHLGHNLLEEINLDVLESLSSVQEILVDNNRLTFLAKVNVSF------PNLKRVAI 470

  Fly   413 DG 414
            :|
  Fly   471 EG 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alrm	NP_651393.1	LRR_RI	84..354	CDD:238064	90/316 (28%)
		LRR_8	91..149	CDD:290566	11/57 (19%)
		leucine-rich repeat	91..114	CDD:275380	5/22 (23%)
		leucine-rich repeat	115..138	CDD:275380	3/22 (14%)
		LRR_8	138..197	CDD:290566	22/76 (29%)
		leucine-rich repeat	139..162	CDD:275380	8/40 (20%)
		leucine-rich repeat	163..186	CDD:275380	9/22 (41%)
		LRR_8	185..243	CDD:290566	23/65 (35%)
		leucine-rich repeat	187..210	CDD:275380	8/22 (36%)
		leucine-rich repeat	211..283	CDD:275380	29/94 (31%)
		leucine-rich repeat	284..319	CDD:275380	15/41 (37%)
		LRR_8	318..377	CDD:290566	15/61 (25%)
		leucine-rich repeat	320..343	CDD:275380	6/22 (27%)
		leucine-rich repeat	344..365	CDD:275380	6/20 (30%)
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	41/152 (27%)
		LRR_8	104..164	CDD:290566	12/59 (20%)
		leucine-rich repeat	106..129	CDD:275380	5/22 (23%)
		leucine-rich repeat	130..153	CDD:275380	3/22 (14%)
		leucine-rich repeat	154..195	CDD:275380	8/40 (20%)
		LRR_RI	194..455	CDD:238064	82/273 (30%)
		LRR_8	194..254	CDD:290566	23/59 (39%)
		leucine-rich repeat	196..219	CDD:275380	9/22 (41%)
		leucine-rich repeat	220..243	CDD:275380	8/22 (36%)
		leucine-rich repeat	244..267	CDD:275380	8/22 (36%)
		LRR_8	271..330	CDD:290566	21/68 (31%)
		leucine-rich repeat	272..295	CDD:275380	10/26 (38%)
		leucine-rich repeat	296..319	CDD:275380	7/28 (25%)
		LRR_8	319..380	CDD:290566	22/63 (35%)
		leucine-rich repeat	320..343	CDD:275380	6/22 (27%)
		leucine-rich repeat	344..369	CDD:275380	10/24 (42%)
		LRR_8	368..428	CDD:290566	16/62 (26%)
		leucine-rich repeat	370..393	CDD:275380	6/22 (27%)
		leucine-rich repeat	394..417	CDD:275380	6/22 (27%)
		leucine-rich repeat	418..441	CDD:275380	7/22 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45617
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010