DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alrm and NRROS

DIOPT Version :9

Sequence 1:	NP_651393.1	Gene:	alrm / 43074	FlyBaseID:	FBgn0039332	Length:	471	Species:	Drosophila melanogaster
Sequence 2:	NP_940967.1	Gene:	NRROS / 375387	HGNCID:	24613	Length:	692	Species:	Homo sapiens

Alignment Length:	625	Identity:	142/625 - (22%)
Similarity:	210/625 - (33%)	Gaps:	207/625 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LLSLQVVLILPPSYHLATPSSGSGQLRRLWLQDHCSAGICTNVVIGRSDYVILSQAPIGGT---- 67
            ||.|.:.|    .:|..|    .|...|.......|.|:| .:|.|.:|....|.|.:..:
Human     3 LLPLWLCL----GFHFLT----VGWRNRSGTATAASQGVC-KLVGGAADCRGQSLASVPSSLPPH 58

  Fly    68 -TMLTFLNSSIAKIPHLLFDTFPDLQVLRMENCSLETFEKPQFEGASNLMSLFLGYN-------- 123
             .|||...:.:..:.:.....:|.|:.|.:.:|.||...:..|:...:|.||.||.|
Human    59 ARMLTLDANPLKTLWNHSLQPYPLLESLSLHSCHLERISRGAFQEQGHLRSLVLGDNCLSENYEE 123

  Fly   124 -----------RLKDIPKNIF------LGADNLATLH---LQGNQLKQLGNHSFHALKEVKELSL 168
                       |..|:..|..      |...||::|.   |.||.:.:|.:..|..|:.::||.|
Human   124 TAAALHALPGLRRLDLSGNALTEDMAALMLQNLSSLRSVSLAGNTIMRLDDSVFEGLERLRELDL 188

  Fly   169 AENQLEQISLGVFSGMRKLMDLNLAGNRLD-----ALPR-GVFDRNLNLTKLNLARNRFTAFESE 227
            ..|.:.:|..|.|.|:.:|..||||.|.|.     .|.| .|.:.:.|:.:..||.....|||.|
Human   189 QRNYIFEIEGGAFDGLAELRHLNLAFNNLPCIVDFGLTRLRVLNVSYNVLEWFLATGGEAAFELE 253

  Fly   228 LLKLQ-------PVFTQ------------------------------------------------ 237
            .|.|.       |:..|
Human   254 TLDLSHNQLLFFPLLPQYSKLRTLLLRDNNMGFYRDLYNTSSPREMVAQFLLVDGNVTNITTVSL 318

  Fly   238 --------------LDISGNIFQELTLNFTMLDVAIAH-----SC----DLRRLTVYGVIHELDL 279
                          ||:|.|.||.|...|.....:::|     :|    .:|.....|.:.||||
Human   319 WEEFSSSDLADLRFLDMSQNQFQYLPDGFLRKMPSLSHLNLHQNCLMTLHIREHEPPGALTELDL 383

  Fly   280 HNNSLREMPHIP----------------------------LAANVSSLDLSHN-----PL---GN 308
            .:|.|.|:...|                            .|.|:::||:|||     ||   .:
Human   384 SHNQLSELHLAPGLASCLGSLRLFNLSSNQLLGVPPGLFANARNITTLDMSHNQISLCPLPAASD 448

  Fly   309 LQGNP----LRRFTSLLRLNLSATGAHELPEGLFKKQSHLQMLDISGN------SIYSLKITIFD 363
            ..|.|    .|...||..|:|...|...||:..|:..| |..||:|.|      |:..|:    |
Human   449 RVGPPSCVDFRNMASLRSLSLEGCGLGALPDCPFQGTS-LTYLDLSSNWGVLNGSLAPLQ----D 508

  Fly   364 SLKALQYFYFQQNNWNCDFLQLLMSSFVKRKDISFMED--ITAPELVDDYVDGIACWYESDKQSK 426
            ....||....:....:..|:.|..|.|...:|:....:  .|.|..
Human   509 VAPMLQVLSLRNMGLHSSFMALDFSGFGNLRDLDLSGNCLTTFPRF------------------- 554

  Fly   427 KCESGGSDAAMELSVVRNEI-----KTFTELVEKKFVKVY 461
                |||.|...|.:.||.:     |..:|.:.:....:|
Human   555 ----GGSLALETLDLRRNSLTALPQKAVSEQLSRGLRTIY 590

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alrm	NP_651393.1	LRR_RI	84..354	CDD:238064	101/427 (24%)
		LRR_8	91..149	CDD:290566	22/85 (26%)
		leucine-rich repeat	91..114	CDD:275380	6/22 (27%)
		leucine-rich repeat	115..138	CDD:275380	10/47 (21%)
		LRR_8	138..197	CDD:290566	23/61 (38%)
		leucine-rich repeat	139..162	CDD:275380	8/25 (32%)
		leucine-rich repeat	163..186	CDD:275380	8/22 (36%)
		LRR_8	185..243	CDD:290566	24/132 (18%)
		leucine-rich repeat	187..210	CDD:275380	10/28 (36%)
		leucine-rich repeat	211..283	CDD:275380	26/149 (17%)
		leucine-rich repeat	284..319	CDD:275380	15/74 (20%)
		LRR_8	318..377	CDD:290566	19/64 (30%)
		leucine-rich repeat	320..343	CDD:275380	7/22 (32%)
		leucine-rich repeat	344..365	CDD:275380	8/26 (31%)
NRROS	NP_940967.1	leucine-rich repeat	42..61	CDD:275380	3/18 (17%)
		LRR 1. /evidence=ECO:0000255	58..79		3/20 (15%)
		leucine-rich repeat	62..82	CDD:275380	2/19 (11%)
		LRR_RI	76..>285	CDD:238064	55/208 (26%)
		LRR_8	81..144	CDD:290566	16/62 (26%)
		LRR 2. /evidence=ECO:0000255	82..103		6/20 (30%)
		leucine-rich repeat	83..106	CDD:275380	6/22 (27%)
		LRR 3. /evidence=ECO:0000255	106..127		6/20 (30%)
		leucine-rich repeat	107..133	CDD:275380	6/25 (24%)
		LRR 4. /evidence=ECO:0000255	133..155		4/21 (19%)
		leucine-rich repeat	134..158	CDD:275380	6/23 (26%)
		LRR_8	157..217	CDD:290566	21/59 (36%)
		LRR 5. /evidence=ECO:0000255	158..179		6/20 (30%)
		leucine-rich repeat	159..182	CDD:275380	7/22 (32%)
		LRR 6. /evidence=ECO:0000255	182..203		7/20 (35%)
		leucine-rich repeat	183..206	CDD:275380	8/22 (36%)
		LRR 7. /evidence=ECO:0000255	206..227		8/20 (40%)
		leucine-rich repeat	207..227	CDD:275380	8/19 (42%)
		leucine-rich repeat	228..251	CDD:275380	5/22 (23%)
		LRR 8. /evidence=ECO:0000255	228..239		2/10 (20%)
		LRR 9. /evidence=ECO:0000255	251..272		6/20 (30%)
		leucine-rich repeat	252..273	CDD:275380	5/20 (25%)
		LRR 10. /evidence=ECO:0000255	273..294		0/20 (0%)
		LRR 11. /evidence=ECO:0000255	329..350		8/20 (40%)
		LRR_8	330..388	CDD:290566	17/57 (30%)
		leucine-rich repeat	330..353	CDD:275380	8/22 (36%)
		LRR 12. /evidence=ECO:0000255	353..374		3/20 (15%)
		leucine-rich repeat	354..377	CDD:275380	3/22 (14%)
		LRR_RI	357..594	CDD:238064	59/262 (23%)
		LRR 13. /evidence=ECO:0000255	377..398		8/20 (40%)
		LRR_8	378..438	CDD:290566	15/59 (25%)
		leucine-rich repeat	378..403	CDD:275380	8/24 (33%)
		LRR 14. /evidence=ECO:0000255	403..424		0/20 (0%)
		leucine-rich repeat	404..427	CDD:275380	1/22 (5%)
		LRR 15. /evidence=ECO:0000255	427..447		8/19 (42%)
		leucine-rich repeat	428..463	CDD:275380	10/34 (29%)
		LRR 16. /evidence=ECO:0000255	463..484		8/20 (40%)
		leucine-rich repeat	464..486	CDD:275380	7/21 (33%)
		LRR 17. /evidence=ECO:0000255	486..507		7/21 (33%)
		leucine-rich repeat	487..512	CDD:275380	8/28 (29%)
		LRR 18. /evidence=ECO:0000255	512..534		4/21 (19%)
		LRR_8	513..570	CDD:290566	16/79 (20%)
		leucine-rich repeat	513..537	CDD:275380	6/23 (26%)
		LRR 19. /evidence=ECO:0000255	537..558		5/43 (12%)
		leucine-rich repeat	538..559	CDD:275380	6/43 (14%)
		LRR 20. /evidence=ECO:0000255	559..580		5/20 (25%)
		LRR 21. /evidence=ECO:0000255	585..594		1/6 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45617
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100