DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment alrm and 18w

DIOPT Version :9

Sequence 1:NP_651393.1 Gene:alrm / 43074 FlyBaseID:FBgn0039332 Length:471 Species:Drosophila melanogaster
Sequence 2:NP_476814.1 Gene:18w / 37277 FlyBaseID:FBgn0004364 Length:1385 Species:Drosophila melanogaster


Alignment Length:499 Identity:112/499 - (22%)
Similarity:190/499 - (38%) Gaps:119/499 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    42 SAGICTNVVIGRSDYVILSQAPIGGTTMLTFLNSSIAKIPHLLFDTFPD---------LQVLRME 97
            |..:|....:..::      ..:.|.:.|..|:.|..::..|     ||         ||.|.::
  Fly   190 SEKLCAGSALSNAN------GAVSGGSELQTLDVSFNELRSL-----PDAWGASRLRRLQTLSLQ 243

  Fly    98 NCSLETFEKPQFEGASNLMSLFLGYNRLKDIPKNIFLGADNLATLHLQGNQLKQLGNHSFHALKE 162
            :.::.|.......|.|:|..|.:.||.|..:|...|.|...|..||||||.|.:|.....|.|::
  Fly   244 HNNISTLAPNALAGLSSLRVLNISYNHLVSLPSEAFAGNKELRELHLQGNDLYELPKGLLHRLEQ 308

  Fly   163 VKELSLAENQL--EQISLGVFSGMRKLMDLNLAGNRLDA------------------------LP 201
            :..|.|:.|||  ..:....|:|:.:|:.|||:.|.|..                        :.
  Fly   309 LLVLDLSGNQLTSHHVDNSTFAGLIRLIVLNLSNNALTRIGSKTFKELYFLQILDMRNNSIGHIE 373

  Fly   202 RGVFDRNLNLTKLNLARNRFTAFESELLKLQPVFTQLDISGNIFQELTLNFTMLDVAIAHSCDLR 266
            .|.|....||..||||.||....::.:.....|.|:|.::.|:            |:|..|...|
  Fly   374 EGAFLPLYNLHTLNLAENRLHTLDNRIFNGLYVLTKLTLNNNL------------VSIVESQAFR 426

  Fly   267 RLTVYGVIHELDLHNNSLREMPH-IPLAANVSSLDLSHNPLGNLQGNPLRRFTSLLRLNLSATGA 330
            ..:   .:.||||.:|.|.|:|. :...:.:.:|||..|.:...:.|..|....|..|.|.....
  Fly   427 NCS---DLKELDLSSNQLTEVPEAVQDLSMLKTLDLGENQISEFKNNTFRNLNQLTGLRLIDNRI 488

  Fly   331 HELPEGLFKKQSHLQMLDISGNSIYSLKITIFD-----------------------SLKALQYFY 372
            ..:..|:|:....|.:|:::.|.|.|::...||                       :|.:|.:..
  Fly   489 GNITVGMFQDLPRLSVLNLAKNRIQSIERGAFDKNTEIEAIRLDKNFLTDINGIFATLASLLWLN 553

  Fly   373 FQQNN--WNCDFLQLLMSSFVKRKDISFMEDITAPELVDDYVDGIACWYESDKQ----------S 425
            ..:|:  |   |....:.|.:|..||.           .:|::.:..:|:..::          :
  Fly   554 LSENHLVW---FDYAFIPSNLKWLDIH-----------GNYIEALGNYYKLQEEIRVTTLDASHN 604

  Fly   426 KKCESGGSDA--AMELSVVRNEI------KTFTELVEKKFVKVY 461
            :..|.|....  ::||..:.|.|      .||.:......|.:|
  Fly   605 RITEIGAMSVPNSIELLFINNNIIGQIQANTFVDKTRLARVDLY 648

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
alrmNP_651393.1 LRR_RI 84..354 CDD:238064 80/305 (26%)
LRR_8 91..149 CDD:290566 21/57 (37%)
leucine-rich repeat 91..114 CDD:275380 5/22 (23%)
leucine-rich repeat 115..138 CDD:275380 8/22 (36%)
LRR_8 138..197 CDD:290566 23/60 (38%)
leucine-rich repeat 139..162 CDD:275380 11/22 (50%)
leucine-rich repeat 163..186 CDD:275380 7/24 (29%)
LRR_8 185..243 CDD:290566 19/81 (23%)
leucine-rich repeat 187..210 CDD:275380 8/46 (17%)
leucine-rich repeat 211..283 CDD:275380 19/71 (27%)
leucine-rich repeat 284..319 CDD:275380 9/35 (26%)
LRR_8 318..377 CDD:290566 14/81 (17%)
leucine-rich repeat 320..343 CDD:275380 5/22 (23%)
leucine-rich repeat 344..365 CDD:275380 7/43 (16%)
18wNP_476814.1 leucine-rich repeat 66..91 CDD:275380
leucine-rich repeat 92..115 CDD:275380
LRR_8 115..181 CDD:290566
leucine-rich repeat 116..146 CDD:275380
leucine-rich repeat 147..170 CDD:275380
leucine-rich repeat 171..201 CDD:275380 2/10 (20%)
LRR_RI 210..464 CDD:238064 74/273 (27%)
leucine-rich repeat 212..236 CDD:275380 6/28 (21%)
LRR_8 235..295 CDD:290566 21/59 (36%)
leucine-rich repeat 237..260 CDD:275380 5/22 (23%)
leucine-rich repeat 261..284 CDD:275380 8/22 (36%)
LRR_8 283..345 CDD:290566 23/61 (38%)
leucine-rich repeat 285..308 CDD:275380 11/22 (50%)
leucine-rich repeat 309..334 CDD:275380 7/24 (29%)
LRR_8 334..393 CDD:290566 15/58 (26%)
leucine-rich repeat 335..358 CDD:275380 6/22 (27%)
leucine-rich repeat 359..382 CDD:275380 2/22 (9%)
LRR_8 382..441 CDD:290566 21/73 (29%)
leucine-rich repeat 383..406 CDD:275380 7/22 (32%)
leucine-rich repeat 407..430 CDD:275380 7/37 (19%)
LRR_8 431..488 CDD:290566 17/56 (30%)
leucine-rich repeat 431..451 CDD:275380 8/19 (42%)
leucine-rich repeat 454..477 CDD:275380 6/22 (27%)
LRR_8 477..559 CDD:290566 15/81 (19%)
leucine-rich repeat 478..499 CDD:275380 5/20 (25%)
leucine-rich repeat 502..525 CDD:275380 7/22 (32%)
leucine-rich repeat 526..548 CDD:275380 1/21 (5%)
leucine-rich repeat 590..617 CDD:275380 2/26 (8%)
leucine-rich repeat 618..641 CDD:275380 6/22 (27%)
leucine-rich repeat 642..689 CDD:275380 2/7 (29%)
LRRCT 679..736 CDD:214507
leucine-rich repeat 775..796 CDD:275380
LRR_8 797..852 CDD:290566
leucine-rich repeat 797..817 CDD:275380
leucine-rich repeat 818..841 CDD:275380
LRR_8 841..900 CDD:290566
leucine-rich repeat 842..865 CDD:275380
LRR_4 866..907 CDD:289563
leucine-rich repeat 866..889 CDD:275380
leucine-rich repeat 890..911 CDD:275380
TIR 1045..1183 CDD:214587
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR45617
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
22.010

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