Protein Alignment alrm and GP5

DIOPT Version :10

• Sequence 1: NP_651393.1
• Gene: alrm / 43074
• FlyBaseID: FBgn0039332
• Length: 471
• Species: Drosophila melanogaster
• Sequence 2: NP_004479.1
• Gene: GP5 / 2814
• HGNCID: 4443
• Length: 560
• Species: Homo sapiens
• Alignment Length: 391
• Identity: 108/391 - (27%)
• Similarity: 159/391 - (40%)
• Gaps: 71/391 - (18%)

  Fly    27 SGSGQLRRLWLQD-HCSAGICTNVVIGR-SDYVILSQAPIGGTTMLTFLNSSIAKIPHLLFDTFP 89
            ||...|:||.:.| |.||     |..|. ||.:.|.        .|....:.|..:|..|.|...
Human    71 SGMTVLQRLMISDSHISA-----VAPGTFSDLIKLK--------TLRLSRNKITHLPGALLDKMV 122

  Fly    90 DLQVLRMENCSLETFEKPQFEGASNLMSLFLGYNRLKDIPKNIFLGADNLATLHLQGNQLKQLGN 154
            .|:.|.:::.:|...::..|:...||..|.|..|:|..:|.::|...:||..|.|.||.|..|..
Human   123 LLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLSGNNLTHLPK 187

  Fly   155 HSFHALKEVKELSLAENQLEQISLGVFSGMRKLMDLNLAGNRLDALPRGVFDRNLNLTKLNLARN 219
            ....|..:::.|.|..|:|..:..|:.:.:..|.:|....|.:.::..|.|||..||:.|.|:||
Human   188 GLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDRLPNLSSLTLSRN 252

  Fly   220 RFTAFESEL------LKLQPVFTQ--LDISGNIF------QELTLNFTML-DVAIAHSCDLRRLT 269
            ......|.|      |.|..:|..  .::.|.:|      |||.||.|.| .:..|...:|.||.
Human   253 HLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLNRTQLRTLPAAAFRNLSRLR 317

  Fly   270 VYGV-------------------IHELDLHNNSLREMPHIPLAANVSSLDLSHNPLGNLQGNPLR 315
            ..||                   :..|.||:|.|..:|.                 |.|:|....
Human   318 YLGVTLSPRLSALPQGAFQGLGELQVLALHSNGLTALPD-----------------GLLRGLGKL 365

  Fly   316 RFTSLLRLNLSATGAHELPEGLFKKQSHLQMLDISGNSIYSLKITIFDSLKALQYFYFQQNNWNC 380
            |..||.|..|.|     ||..||:..|.|:.:.:..|.:.:|...:|.:|..|.......|:|.|
Human   366 RQVSLRRNRLRA-----LPRALFRNLSSLESVQLDHNQLETLPGDVFGALPRLTEVLLGHNSWRC 425

  Fly   381 D 381
            |
Human   426 D 426

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alrm	NP_651393.1	leucine-rich repeat	91..114	CDD:275380	4/22 (18%)
		LRR	<100..426	CDD:443914	87/316 (28%)
		leucine-rich repeat	115..138	CDD:275380	7/22 (32%)
		leucine-rich repeat	139..162	CDD:275380	8/22 (36%)
		leucine-rich repeat	163..186	CDD:275380	5/22 (23%)
		leucine-rich repeat	187..210	CDD:275380	7/22 (32%)
		leucine-rich repeat	211..283	CDD:275380	28/105 (27%)
		leucine-rich repeat	284..319	CDD:275380	6/34 (18%)
		leucine-rich repeat	320..343	CDD:275380	8/22 (36%)
		leucine-rich repeat	344..365	CDD:275380	4/20 (20%)
GP5	NP_004479.1	LRR	<44..>299	CDD:443914	69/240 (29%)
		LRR 1	75..96		9/25 (36%)
		leucine-rich repeat	76..99	CDD:275380	11/27 (41%)
		LRR 2	99..120		5/28 (18%)
		leucine-rich repeat	100..123	CDD:275380	6/30 (20%)
		LRR 3	123..144		4/20 (20%)
		leucine-rich repeat	124..147	CDD:275380	4/22 (18%)
		LRR 4	147..168		8/20 (40%)
		leucine-rich repeat	148..171	CDD:275380	7/22 (32%)
		LRR 5	171..193		8/21 (38%)
		leucine-rich repeat	172..195	CDD:275380	8/22 (36%)
		LRR 6	195..216		5/20 (25%)
		leucine-rich repeat	196..219	CDD:275380	5/22 (23%)
		LRR 7	219..240		5/20 (25%)
		leucine-rich repeat	220..243	CDD:275380	7/22 (32%)
		LRR 8	243..264		8/20 (40%)
		leucine-rich repeat	244..267	CDD:275380	7/22 (32%)
		LRR 9	267..288		5/20 (25%)
		leucine-rich repeat	268..291	CDD:275380	5/22 (23%)
		LRR_8	291..351	CDD:404697	17/59 (29%)
		LRR 10	291..312		8/20 (40%)
		leucine-rich repeat	292..315	CDD:275380	9/22 (41%)
		leucine-rich repeat	316..338	CDD:275380	3/21 (14%)
		LRR_8	340..399	CDD:404697	22/80 (28%)
		LRR 11	340..361		8/37 (22%)
		leucine-rich repeat	341..364	CDD:275380	9/39 (23%)
		LRR 12	364..385		10/25 (40%)
		leucine-rich repeat	365..388	CDD:275380	10/27 (37%)
		LRR 13	388..409		4/20 (20%)
		leucine-rich repeat	389..410	CDD:275380	4/20 (20%)
		LRRCT	421..472	CDD:214507	4/6 (67%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	469..498