DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment alrm and Lrrc15

DIOPT Version :9

Sequence 1:NP_651393.1 Gene:alrm / 43074 FlyBaseID:FBgn0039332 Length:471 Species:Drosophila melanogaster
Sequence 2:NP_659551.1 Gene:Lrrc15 / 246296 RGDID:70551 Length:578 Species:Rattus norvegicus


Alignment Length:411 Identity:100/411 - (24%)
Similarity:160/411 - (38%) Gaps:69/411 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 WWLLSLQVVLILPPSYHLATPSSGSGQLRRLWLQDHCSAGICTNVVIGRSDYVILSQAP-----I 64
            |..:|||||     :.|:..            |.::....|...:.:......:.:..|     :
  Rat    53 WNAMSLQVV-----NTHITE------------LPENLFLNISALIALKMEKNELSTIMPGAFRNL 100

  Fly    65 GGTTMLTFLNSSIAKIPHLLFDTFPDLQVLRMENCSLETFEKPQFEGASNLMSLFLGYNRLKDIP 129
            |....|:..|:.:..:|..:|....:|:.|.:.|..|...:..||...|||..|.|..|.|:.||
  Rat   101 GSLRYLSLANNKLRMLPIRVFQDVNNLESLLLSNNQLVQIQPAQFSQFSNLRELQLHGNNLESIP 165

  Fly   130 KNIFLGADNLATLHLQGNQLKQLGNHSFHALKEVKELSLAENQLEQISLGVFSGMRKLMDLNLAG 194
            :..|.....|..|:|..|....|....|..|..::.|.|.||:|..|.:|.|..:..|.:|.|..
  Rat   166 EEAFDHLVGLTKLNLGRNSFTHLSPRLFQHLGNLQVLRLHENRLSDIPMGTFDALGNLQELALQE 230

  Fly   195 NRLDALPRGVFDRNLNLTKLNLARNRFTAFESELLKLQPVFTQLDISGNIFQELTLNFTMLDVAI 259
            |::..|..|:|..|.||.:|.|:.|..:.....:....|...:|.:.||..:||:..        
  Rat   231 NQIGTLSPGLFHNNRNLQRLYLSNNHISQLPPGIFMQLPQLNKLTLFGNSLRELSPG-------- 287

  Fly   260 AHSCDLRRLTVYGV---IHELDLHNN---------------------SLREMPHIPLAA-----N 295
                      |:|.   :.||.|:||                     |..::.:|...|     |
  Rat   288 ----------VFGPMPNLRELWLYNNHITSLADNTFSHLNQLQVLILSHNQLTYISPGAFNGLTN 342

  Fly   296 VSSLDLSHNPLGNLQGNPLRRFTSLLRLNLSATGAHELPEGLFKKQSHLQMLDISGNSIYSLKIT 360
            :..|.|..|.|.:|..|..|...:|..::|.:....:||..:|...:.|..:.:..|::.:|.:.
  Rat   343 LRELSLHTNALQDLDSNVFRSLANLQNISLQSNRLRQLPGSIFANVNGLTTIQLQNNNLENLPLG 407

  Fly   361 IFDSLKALQYFYFQQNNWNCD 381
            |||.|..|.......|.|.||
  Rat   408 IFDHLVNLCELRLYDNPWRCD 428

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
alrmNP_651393.1 LRR_RI 84..354 CDD:238064 76/298 (26%)
LRR_8 91..149 CDD:290566 20/57 (35%)
leucine-rich repeat 91..114 CDD:275380 6/22 (27%)
leucine-rich repeat 115..138 CDD:275380 8/22 (36%)
LRR_8 138..197 CDD:290566 19/58 (33%)
leucine-rich repeat 139..162 CDD:275380 7/22 (32%)
leucine-rich repeat 163..186 CDD:275380 8/22 (36%)
LRR_8 185..243 CDD:290566 15/57 (26%)
leucine-rich repeat 187..210 CDD:275380 8/22 (36%)
leucine-rich repeat 211..283 CDD:275380 17/95 (18%)
leucine-rich repeat 284..319 CDD:275380 10/39 (26%)
LRR_8 318..377 CDD:290566 13/58 (22%)
leucine-rich repeat 320..343 CDD:275380 5/22 (23%)
leucine-rich repeat 344..365 CDD:275380 6/20 (30%)
Lrrc15NP_659551.1 LRR_8 54..113 CDD:290566 12/75 (16%)
LRR 1 54..75 7/37 (19%)
LRR 2 78..99 1/20 (5%)
leucine-rich repeat 79..102 CDD:275380 1/22 (5%)
LRR_RI <94..303 CDD:238064 61/226 (27%)
LRR_8 102..161 CDD:290566 16/58 (28%)
LRR 3 102..123 4/20 (20%)
leucine-rich repeat 103..126 CDD:275380 4/22 (18%)
LRR 4 126..147 6/20 (30%)
leucine-rich repeat 127..150 CDD:275380 6/22 (27%)
LRR_8 149..209 CDD:290566 21/59 (36%)
LRR 5 150..171 9/20 (45%)
leucine-rich repeat 151..174 CDD:275380 8/22 (36%)
LRR 6 174..195 6/20 (30%)
leucine-rich repeat 175..198 CDD:275380 7/22 (32%)
LRR_8 198..257 CDD:290566 21/58 (36%)
LRR 7 198..219 8/20 (40%)
leucine-rich repeat 199..222 CDD:275380 8/22 (36%)
LRR 8 222..243 7/20 (35%)
leucine-rich repeat 223..246 CDD:275380 8/22 (36%)
LRR_8 245..305 CDD:290566 18/77 (23%)
LRR 9 246..267 5/20 (25%)
leucine-rich repeat 247..270 CDD:275380 4/22 (18%)
LRR 10 270..291 6/38 (16%)
leucine-rich repeat 271..294 CDD:275380 7/40 (18%)
LRR_8 293..353 CDD:290566 12/59 (20%)
LRR 11 294..315 5/20 (25%)
leucine-rich repeat 295..318 CDD:275380 5/22 (23%)
LRR_4 318..358 CDD:289563 9/39 (23%)
LRR 12 318..339 3/20 (15%)
leucine-rich repeat 319..342 CDD:275380 3/22 (14%)
LRR 13 342..363 7/20 (35%)
leucine-rich repeat 343..364 CDD:275380 7/20 (35%)
LRR_8 366..424 CDD:290566 13/57 (23%)
LRR 14 366..387 5/20 (25%)
leucine-rich repeat 367..387 CDD:275380 5/19 (26%)
LRR 15 390..411 5/20 (25%)
leucine-rich repeat 391..412 CDD:275380 6/20 (30%)
TPKR_C2 423..>462 CDD:301599 4/6 (67%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 476..500
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR45617
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
33.010

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