Protein Alignment alrm and lron-5

DIOPT Version :10

• Sequence 1: NP_651393.1
• Gene: alrm / 43074
• FlyBaseID: FBgn0039332
• Length: 471
• Species: Drosophila melanogaster
• Sequence 2: NP_497943.2
• Gene: lron-5 / 184307
• WormBaseID: WBGene00008656
• Length: 656
• Species: Caenorhabditis elegans
• Alignment Length: 518
• Identity: 110/518 - (21%)
• Similarity: 188/518 - (36%)
• Gaps: 139/518 - (26%)

  Fly    40 HCSAGICTNVVIGRSDYVILSQAPIGGTTMLTFLNS-SIAKIPHLLFDTFPDLQVLRMENCSLET 103
            ||.....::.|:.....:::....:..|.....||| ::.:.||.||  .|:|:||||..|.:..
 Worm    23 HCDCDFISHTVVCNRPSLLIRTVSMLPTIRQLHLNSLNLPQPPHFLF--HPNLRVLRMSRCGMHE 85

  Fly   104 FEKPQFEGASNLMSLFLGYNRLKDIPKNIFLGADNLATLHLQGNQLKQLGNHSFHALKEV--KEL 166
            .....|.....|..:.|..|.|:.:|..:......|..|.|..|:|..|...::.....|  ::|
 Worm    86 IPGSTFLPLPGLEVIDLSNNHLETLPPTVLRSLKFLRVLILSNNRLSNLDQLTWILAPGVVLEQL 150

  Fly   167 SLAENQLE-QISLGVFSGMRKLMDLNLAGNRLDA----------LPRGVFDR---------NLN- 210
            .|:.|.:. ..|:.||..:|:|.   |:..|:::          || |..||         |||
 Worm   151 DLSGNPIAIATSMTVFPPVRQLF---LSDTRMESVNETAIMFKKLP-GKCDRDVCRHIPIHNLNV 211

  Fly   211 --LTKLNLARNRFTAFESELLKLQPVFTQLDISGNI----FQE--------LTLNFTMLDVAI-- 259
              :|.::.:.||....:|..|.:....|.:|:|...    |:|        .:||.:...:.:
 Worm   212 SIITTIDFSSNRDLEIDSGALDVFSNATYVDLSNTRLPVGFEEWLERKSRVKSLNISHCQLPLHE 276

  Fly   260 ---------AHSCDL-----RRL-------------------TVY---GVIHELDLHNNSLREMP 288
                     .||.|:     :||                   :||   ..:..|.|..|...|.|
 Worm   277 DTWTACGQFLHSLDISGIGAKRLRFSRFCPIRSVFARDNLISSVYIDAVSMESLHLERNMFSEFP 341

  Fly   289 HIPLAANVS---SLDLSHNPLGNLQGNPLRRFTSLLRLNLSATGAHEL-PEGLFKKQSHLQMLDI 349
            ..|....::   :|.||||.:.:|..:.|:.:.:|...::|:....|: |:........|..||:
 Worm   342 IPPPGVELTELHTLGLSHNLMTSLPPHALQSYPNLQHFDVSSNQLSEIDPQAFPSIGLGLISLDL 406

  Fly   350 SGNSIYSLKITIFDSLKALQYFYFQQNNWNCDFLQLLMSSFVKRKDISFMEDITAPELVDDYVDG 414
            |.|.:.||...|..||..|                          |:||.   |...|...:..|
 Worm   407 SSNQLSSLPHPILPSLLLL--------------------------DLSFN---TISHLDPHFFTG 442

  Fly   415 I-----------------------ACWYES-DKQSKKCESGGSDAAMELSVVRNEIKTFTELV 453
            :                       .||.:. |:.:...:...|::.:|.|:....::|...|:
 Worm   443 LPMLQQLRIASNPTLFSRCPNRDSPCWSDHLDELTSLVDLDISNSGLEFSLHWRHLRTLKSLI 505

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alrm	NP_651393.1	leucine-rich repeat	91..114	CDD:275380	7/22 (32%)
		LRR	<100..426	CDD:443914	87/428 (20%)
		leucine-rich repeat	115..138	CDD:275380	5/22 (23%)
		leucine-rich repeat	139..162	CDD:275380	6/22 (27%)
		leucine-rich repeat	163..186	CDD:275380	7/25 (28%)
		leucine-rich repeat	187..210	CDD:275380	9/41 (22%)
		leucine-rich repeat	211..283	CDD:275380	21/121 (17%)
		leucine-rich repeat	284..319	CDD:275380	10/37 (27%)
		leucine-rich repeat	320..343	CDD:275380	4/23 (17%)
		leucine-rich repeat	344..365	CDD:275380	8/20 (40%)
lron-5	NP_497943.2	LRR	<48..>186	CDD:443914	38/142 (27%)
		leucine-rich repeat	51..72	CDD:275380	7/22 (32%)
		leucine-rich repeat	73..96	CDD:275380	7/22 (32%)
		leucine-rich repeat	97..120	CDD:275380	5/22 (23%)
		leucine-rich repeat	121..146	CDD:275380	6/24 (25%)
		leucine-rich repeat	147..168	CDD:275380	6/20 (30%)
		leucine-rich repeat	169..208	CDD:275380	9/42 (21%)
		leucine-rich repeat	209..237	CDD:275380	7/27 (26%)
		leucine-rich repeat	238..284	CDD:275380	7/45 (16%)
		leucine-rich repeat	327..351	CDD:275380	6/23 (26%)
		LRR	<348..>555	CDD:443914	36/187 (19%)
		leucine-rich repeat	352..375	CDD:275380	7/22 (32%)
		leucine-rich repeat	376..391	CDD:275380	3/14 (21%)
		leucine-rich repeat	401..445	CDD:275380	17/72 (24%)
		leucine-rich repeat	446..478	CDD:275380	3/31 (10%)
		leucine-rich repeat	479..500	CDD:275380	3/20 (15%)
		leucine-rich repeat	501..522	CDD:275380	1/5 (20%)
		leucine-rich repeat	523..544	CDD:275380
		LRRCT	553..601	CDD:214507