DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alrm and sym-1

DIOPT Version :9

Sequence 1:	NP_651393.1	Gene:	alrm / 43074	FlyBaseID:	FBgn0039332	Length:	471	Species:	Drosophila melanogaster
Sequence 2:	NP_510426.1	Gene:	sym-1 / 181555	WormBaseID:	WBGene00006366	Length:	680	Species:	Caenorhabditis elegans

Alignment Length:	372	Identity:	84/372 - (22%)
Similarity:	156/372 - (41%)	Gaps:	64/372 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LLSLQVVLILPPSYHLATPSSGSGQLRRLWLQDHCSAGICTNVVIGRSDYVILSQAPIGGTTMLT 71
            ||.|.|.|::.|:.....|.....|..       ||   |.:.|.|    .::..:...|..|:.
Worm     2 LLRLCVALLVLPACLAFCPKLFQNQTA-------CS---CDSTVEG----PVIKCSGHDGLRMVE 52

  Fly    72 FLNSSIAKIPHLLFDTFPDLQVLRMENCSLETFEKPQFEGASNLMSLFLGYNRLKDIPKNIFLGA 136
            .|:::          |..:::.|.:||..:.......|: ...:..|.|..||::.|..:.|.|.
Worm    53 KLSTT----------TTMEVRELALENADIIEVGPKAFK-TLRIKKLILSNNRIEKIHDHAFTGL 106

  Fly   137 DN-LATLHLQGNQLKQLGNHSFHALKEVKELSLAENQLEQISLGVFSGMRKLMDLNLAGNRLDAL 200
            :| :..|.|..|.||::...:...|:.:..|||..|::|.|:...|..|..|:|:||..|::.::
Worm   107 ENVMQELSLSENNLKEVPTSALAGLRVLNILSLKCNKIENITTKAFVNMTSLIDVNLGCNQICSM 171

  Fly   201 PRGVF-DRNLNLTKLNLARNRFTAFESELLKLQPVFTQLDISGNIFQELTLNFTMLDVAIAHSCD 264
            ....| :..::|..|.|..|..|.|.|:.::            |:...:.|:..
Worm   172 AADTFANVKMSLQNLILDNNCMTEFPSKAVR------------NMNNLIALHIK----------- 213

  Fly   265 LRRLTVYGVIHELDLHNNSLREMPHIPLAANVSSLDLSHNPLGNLQGNPLRRFTSLLRLNLSATG 329
                  |..|       |::|:...:.| .::|.|.|:.|.:..::|..|:...:|..|.|:...
Worm   214 ------YNKI-------NAIRQNDFVNL-TSLSMLSLNGNNISEIKGGALQNTPNLHYLYLNENN 264

  Fly   330 AHELPEGLFKKQSHLQMLDISGNSIYSLKITIFDSLKALQYFYFQQN 376
            ...|..|:.::...||:||:|.|:...:...:|:.|:::|:.....|
Worm   265 LQTLDNGVLEQFKQLQVLDLSFNNFTDITKEMFEGLESIQHLNLDSN 311

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alrm	NP_651393.1	LRR_RI	84..354	CDD:238064	64/271 (24%)
		LRR_8	91..149	CDD:290566	15/58 (26%)
		leucine-rich repeat	91..114	CDD:275380	4/22 (18%)
		leucine-rich repeat	115..138	CDD:275380	7/22 (32%)
		LRR_8	138..197	CDD:290566	20/59 (34%)
		leucine-rich repeat	139..162	CDD:275380	6/22 (27%)
		leucine-rich repeat	163..186	CDD:275380	8/22 (36%)
		LRR_8	185..243	CDD:290566	13/58 (22%)
		leucine-rich repeat	187..210	CDD:275380	6/23 (26%)
		leucine-rich repeat	211..283	CDD:275380	11/71 (15%)
		leucine-rich repeat	284..319	CDD:275380	8/34 (24%)
		LRR_8	318..377	CDD:290566	15/59 (25%)
		leucine-rich repeat	320..343	CDD:275380	5/22 (23%)
		leucine-rich repeat	344..365	CDD:275380	7/20 (35%)
sym-1	NP_510426.1	leucine-rich repeat	62..81	CDD:275380	3/18 (17%)
		LRR_5	74..208	CDD:290045	37/146 (25%)
		LRR_RI	81..384	CDD:238064	63/269 (23%)
		leucine-rich repeat	86..108	CDD:275380	7/21 (33%)
		leucine-rich repeat	110..133	CDD:275380	6/22 (27%)
		leucine-rich repeat	134..157	CDD:275380	8/22 (36%)
		leucine-rich repeat	158..182	CDD:275380	6/23 (26%)
		LRR_8	182..241	CDD:290566	18/95 (19%)
		leucine-rich repeat	183..206	CDD:275380	8/34 (24%)
		leucine-rich repeat	207..230	CDD:275380	6/47 (13%)
		leucine-rich repeat	231..254	CDD:275380	6/22 (27%)
		LRR_8	253..313	CDD:290566	15/59 (25%)
		leucine-rich repeat	255..278	CDD:275380	5/22 (23%)
		leucine-rich repeat	279..302	CDD:275380	8/22 (36%)
		LRR_8	302..384	CDD:290566	2/10 (20%)
		leucine-rich repeat	303..323	CDD:275380	2/9 (22%)
		leucine-rich repeat	350..373	CDD:275380
		leucine-rich repeat	374..394	CDD:275380
		leucine-rich repeat	399..410	CDD:275378
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45617
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100