DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alrm and flrt1b

DIOPT Version :9

Sequence 1:	NP_651393.1	Gene:	alrm / 43074	FlyBaseID:	FBgn0039332	Length:	471	Species:	Drosophila melanogaster
Sequence 2:	XP_005169675.1	Gene:	flrt1b / 100144397	ZFINID:	ZDB-GENE-080327-6	Length:	715	Species:	Danio rerio

Alignment Length:	463	Identity:	112/463 - (24%)
Similarity:	178/463 - (38%)	Gaps:	105/463 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LWWLLSLQVVLILPPSYHLATPSSGSGQLRRLWLQDH--C-SAGICTNVVIGRSDYVILSQAPIG 65
            |:.||....:|:....:..||.::....|....||..  | ||..|.:..|..:|..:....|:.
Zfish    13 LFLLLLCLTLLVEVLEFAAATAAAAEAALGEAELQGEVPCPSACRCDDGFIYCNDRGLTLIPPLP 77

  Fly    66 GTTMLTFLNSSIAKIPHLLFDTFPDLQVLRMENCSLETFEKPQFEGASNLMSLFLGYNRLKDIPK 130
            .|..:.:|.::                  |::|..|.|    ..|....:..::|..|.|.|.|.
Zfish    78 LTAAVLYLQNN------------------RIDNAGLPT----SLERRLTVRVVYLYDNELDDFPT 120

  Fly   131 NIFLGADNLATLHLQGNQLKQLGNHSFHALKEVKELSLAENQLEQISL--GVFSGMRKLMDLNLA 193
            ::   ..:|..||||.|.::.|...:...|..:::|.:.:|.:..:|:  ..|:...:|..|.|:
Zfish   121 HL---PPSLRELHLQDNNIRTLPRSALARLPLLEKLHMDDNSISTVSIEDKAFTNNPRLRLLFLS 182

  Fly   194 GNRLDALPRGVFDRNLNLTKLNLARNRFTAFESELLKLQPVFTQLDISGNIFQELTLNFTMLDVA 258
            .|.|.::|.|:   ..:|.:|.|..||.:...:...:......:|.:.||    |..|..:.|..
Zfish   183 RNHLSSIPSGL---PASLEELRLDDNRISTIPTHAFRGLSSLRRLFLDGN----LLANQRIADDT 240

  Fly   259 IAHSCDLRRLTVYGVIHELDLHNNSLREMPHIPLAANVSSLDLSHNPLGNLQGNPLRRFTSLLRL 323
            .:.   |..||      ||.|..|||:..|     .|:.||                   .||||
Zfish   241 FSR---LSNLT------ELSLVRNSLQAPP-----LNLPSL-------------------HLLRL 272

  Fly   324 NLSATGAHELPEGLFKKQSHLQMLDISGNSIYSLKITIFDSLKALQYFYFQQNNWNC-------- 380
            .|.......:|.|.......||.||||||::.:|...:|..|.:|.....:.|.|.|
Zfish   273 YLQDNAIAHMPRGSLDGMRRLQKLDISGNNLTTLPRGLFKDLDSLSQLLVRGNPWYCGCNLRWLH 337

  Fly   381 DFLQLLMSSFVKRKDISFMEDIT--APELVDDYVDGIACWYESDKQSKKCE-----SGGSDAAME 438
            |:|....||...|       .:|  |||    .:.|:|. .:...|.:.||     :||
Zfish   338 DWLHERGSSVTVR-------GLTCHAPE----RLRGMAL-RDLSSQLEDCEVTVDAAGG------ 384

  Fly   439 LSVVRNEI 446
              :|.||:
Zfish   385 --MVGNEV 390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alrm	NP_651393.1	LRR_RI	84..354	CDD:238064	68/271 (25%)
		LRR_8	91..149	CDD:290566	16/57 (28%)
		leucine-rich repeat	91..114	CDD:275380	5/22 (23%)
		leucine-rich repeat	115..138	CDD:275380	5/22 (23%)
		LRR_8	138..197	CDD:290566	16/60 (27%)
		leucine-rich repeat	139..162	CDD:275380	8/22 (36%)
		leucine-rich repeat	163..186	CDD:275380	4/24 (17%)
		LRR_8	185..243	CDD:290566	13/57 (23%)
		leucine-rich repeat	187..210	CDD:275380	7/22 (32%)
		leucine-rich repeat	211..283	CDD:275380	17/71 (24%)
		leucine-rich repeat	284..319	CDD:275380	5/34 (15%)
		LRR_8	318..377	CDD:290566	19/58 (33%)
		leucine-rich repeat	320..343	CDD:275380	7/22 (32%)
		leucine-rich repeat	344..365	CDD:275380	10/20 (50%)
flrt1b	XP_005169675.1	LRRNT	51..77	CDD:214470	7/25 (28%)
		leucine-rich repeat	82..104	CDD:275378	6/43 (14%)
		leucine-rich repeat	105..125	CDD:275380	5/22 (23%)
		LRR_RI	<120..305	CDD:238064	58/227 (26%)
		LRR_8	124..186	CDD:290566	16/61 (26%)
		leucine-rich repeat	126..149	CDD:275380	8/22 (36%)
		leucine-rich repeat	150..175	CDD:275380	4/24 (17%)
		LRR_8	174..231	CDD:290566	15/63 (24%)
		leucine-rich repeat	176..196	CDD:275380	7/22 (32%)
		leucine-rich repeat	197..220	CDD:275380	5/22 (23%)
		leucine-rich repeat	221..246	CDD:275380	7/31 (23%)
		leucine-rich repeat	247..268	CDD:275380	12/50 (24%)
		LRR_8	268..326	CDD:290566	19/57 (33%)
		leucine-rich repeat	269..292	CDD:275380	7/22 (32%)
		leucine-rich repeat	293..316	CDD:275380	11/22 (50%)
		LRRCT	325..375	CDD:214507	15/61 (25%)
		fn3	448..515	CDD:278470
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910