DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ND-49L and Ndufs2

DIOPT Version :9

Sequence 1:	NP_651392.2	Gene:	ND-49L / 43073	FlyBaseID:	FBgn0039331	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_001011907.1	Gene:	Ndufs2 / 289218	RGDID:	1307109	Length:	463	Species:	Rattus norvegicus

Alignment Length:	434	Identity:	268/434 - (61%)
Similarity:	333/434 - (76%)	Gaps:	14/434 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 WYPDPEFMNKQQYIVWYP--EGDEWKKRP-----NFKGKQIPPVDRTFRTKLINFGPAHPAAHGV 154
            |.||.|:..:....|.||  |...||..|     ..|.|.:..|       .:||||.|||||||
  Rat    37 WQPDIEWAEQFSGAVMYPSKETAHWKPPPWNDVDVLKEKVVTNV-------TLNFGPQHPAAHGV 94

  Fly   155 LRMILELDNETVLNADPHIGLLHRGTEKLIEYKTYTQALPYFDRLDYVSCMANELAYCLAVEKLL 219
            ||::|||..|.|...||||||||||||||||||||.|||||||||||||.|.||.||.|||||||
  Rat    95 LRLVLELSGEMVRKCDPHIGLLHRGTEKLIEYKTYLQALPYFDRLDYVSMMCNEQAYSLAVEKLL 159

  Fly   220 NVEVPRRAKYIRTMFSEIMRLTNHTMAIGSSVLDCGAITPLFWLFEEREKLYEFSERASGARLHA 284
            |::.|.||::||.:|.||.|:.||.||:.:..||.||:||.||:||||||::||.||.||||:||
  Rat   160 NIQPPPRAQWIRVLFGEITRILNHIMAVTTHALDIGAMTPFFWMFEEREKMFEFYERVSGARMHA 224

  Fly   285 AYIRPGGVASDIPLGFLHDLYQFINQFNERLDEVEDVVTDNRIWRMRNIGIGVISAHDALNYGCT 349
            ||||||||..|:|||.:.|:|:|...|:.|:||||:::|:|||||.|.:.|||:||.||||||.:
  Rat   225 AYIRPGGVHQDLPLGLMDDIYEFSKNFSLRIDEVEEMLTNNRIWRNRTVDIGVVSAEDALNYGFS 289

  Fly   350 GPVLRATGVKWDLRKQQPYDAYDEMDFDVVVGSNGDCYDRYLVRMREMRESVNIIKQCIDAMPPG 414
            |.:||.:|::|||||.||||.||:::|||.:||.||||||||.|:.|||:|:.||:||::.||||
  Rat   290 GVMLRGSGIQWDLRKTQPYDVYDQVEFDVPIGSRGDCYDRYLCRVEEMRQSLRIIEQCLNKMPPG 354

  Fly   415 EIKVDDLKICPPQRSKMKEGMEDLIHHFKHFSQGFRVPPGQTYCAVESPKGEFGAFLISDGSSRP 479
            ||||||.|:.||:|::||..||.||||||.:::|::||||.||.|:|:||||||.:|:|||||||
  Rat   355 EIKVDDAKVSPPKRAEMKTSMESLIHHFKLYTEGYQVPPGATYTAIEAPKGEFGVYLVSDGSSRP 419

  Fly   480 YRCKIRPASYAHLALMAKMAPAHLLADVVAIIGSLDIVFGEIDR 523
            |||||:...:||||.:.||:..|:|||||||||:.|||||||||
  Rat   420 YRCKIKAPGFAHLAGLDKMSKGHMLADVVAIIGTQDIVFGEIDR 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ND-49L	NP_651392.2	PRK06075	142..523	CDD:180385	252/380 (66%)
ND-49L	NP_651392.2	NuoD	142..523	CDD:223722	252/380 (66%)
Ndufs2	NP_001011907.1	PRK06075	77..463	CDD:180385	253/392 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341906
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0649
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60638
OrthoDB	1	1.010	-	-		D212488at33208
OrthoFinder	1	1.000	-	-		FOG0003234
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101051
Panther	1	1.100	-	-	O	PTHR11993
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2189
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.760