Protein Alignment tobi and ROT2

DIOPT Version :10

• Sequence 1: NP_651391.1
• Gene: tobi / 43072
• FlyBaseID: FBgn0261575
• Length: 657
• Species: Drosophila melanogaster
• Sequence 2: NP_009788.3
• Gene: ROT2 / 852530
• SGDID: S000000433
• Length: 954
• Species: Saccharomyces cerevisiae
• Alignment Length: 720
• Identity: 138/720 - (19%)
• Similarity: 257/720 - (35%)
• Gaps: 174/720 - (24%)

  Fly    47 QYELMKGEKSLQTVTFDNFDSSANLVETSSGSYQLTDGQSTVE-----FTL-------------- 92
            |:..:|.::::.:. :....|..:|..:::.::.|.:|..:||     |.|
Yeast   148 QFHFLKQKQTVNSF-WSKISSFLSLSNSTADTFHLRNGDVSVEIFAEPFQLKVYWQNALKLIVNE 211

  Fly    93 ----------VKSGVVAGTGSEITHVKVSRDQVLQGTQPRDCVPLK----------TGSTHWFSG 137
                      .|....|....|.|...:.:|..|.  ...|.:||.          .|||:.:..
Yeast   212 QNFLNIEHHRTKQENFAHVLPEETTFNMFKDNFLY--SKHDSMPLGPESVALDFSFMGSTNVYGI 274

  Fly   138 PEQKQHYWPVERQRHSN----YSYLPKELDNFGVGERYWLNGDGVFLYVESNTPLFIDQNSAAYP 198
            ||   |...:.....|.    |.....::..:.:|....:.|...|::..|:|.:|....:..:.
Yeast   275 PE---HATSLRLMDTSGGKEPYRLFNVDVFEYNIGTSQPMYGSIPFMFSSSSTSIFWVNAADTWV 336

  Fly   199 DQLCLSAISALPYDPRVTSAKFVYH-----------VAVAKDAKAAHRYAVKTFL-------GQP 245
            |         :.||  .:..|.:.|           :::..|        :.|.:       |:|
Yeast   337 D---------IKYD--TSKNKTMTHWISENGVIDVVMSLGPD--------IPTIIDKFTDLTGRP 382

  Fly   246 TGYPDERMVMHPV-WSTWALYKAEVSDDVVRDFAKQILDNGFNNSQLEIDDDWEDC-------YG 302
            ...|...:..|.. |:    |..|:  ||:      .:|:..:...:..|..|.|.       |
Yeast   383 FLPPISSIGYHQCRWN----YNDEM--DVL------TVDSQMDAHMIPYDFIWLDLEYTNDKKY- 434

  Fly   303 AMTFRKNKFPDSKTLTDDLKALGFRVTLWIHPFINNNCTAIYDEAKSKGYLVLDHEGSSDT-QWW 366
             .|::::.||:.|.|...||.||..:.:.|.|.:..: ..|.|...::...|.||.|:... ..|
Yeast   435 -FTWKQHSFPNPKRLLSKLKKLGRNLVVLIDPHLKKD-YEISDRVINENVAVKDHNGNDYVGHCW 497

  Fly   367 NSKPKDAAILDFTKTEVQEWFSKRLKRLQD-----------EDGIDSFKFDAGETSWLPSD---- 416
               |.::..:|......|:.:....:|..|           .|..:...||..||: .|.|
Yeast   498 ---PGNSIWIDTISKYGQKIWKSFFERFMDLPADLTNLFIWNDMNEPSIFDGPETT-APKDLIHD 558

  Fly   417 --------------PVLQASSSMVTPLQAVGD---YVRTVAAFGDMVEVRSAQNTQDQPIFVRIV 464
                          .|.:|:...:..:.:..|   ::.|.|.|..  ..|:|.....
Yeast   559 NYIEERSVHNIYGLSVHEATYDAIKSIYSPSDKRPFLLTRAFFAG--SQRTAATWTG-------- 613

  Fly   465 DKDSEWGWNNGLLTLISSMLQMNLNGYPFVLPDMIGGNGYYEKPPTKELFLRWLQANVFMPALQF 529
            |..:.|.:   |...|..:|..|:.|.||:..|:.|    :.:.||.||..||.||.::.|..:.
Yeast   614 DNVANWDY---LKISIPMVLSNNIAGMPFIGADIAG----FAEDPTPELIARWYQAGLWYPFFRA 671

  Fly   530 SF-------VPWNFDDEAIAISKNFTALHATYTPYIMKLFKRAVDSGEPVNVPLWWIAPTDEVAQ 587
            ..       .|:.|::...:|.::...|.....|.:..:|.::..:|.|:..|::...|......
Yeast   672 HAHIDTKRREPYLFNEPLKSIVRDIIQLRYFLLPTLYTMFHKSSVTGFPIMNPMFIEHPEFAELY 736

  Fly   588 SIYDEFLLGED-IIAAPVVVEGATKRDIYLPEGEWQDGNS--DQVYTGPTWV-MDYAAPLDTLPY 648
            .|.::|..... ::..||...|.::.::..|.|.:.:..|  ..:..|...: .:.:||||.:|.
Yeast   737 HIDNQFYWSNSGLLVKPVTEPGQSETEMVFPPGIFYEFASLHSFINNGTDLIEKNISAPLDKIPL 801

  Fly   649 FLRVG 653
            |:..|
Yeast   802 FIEGG 806

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tobi	NP_651391.1	GH31_NET37	255..621	CDD:269878	86/414 (21%)
ROT2	NP_009788.3	GH31_N	259..380	CDD:270212	21/142 (15%)
		GH31_GANC_GANAB_alpha	380..850	CDD:269889	98/463 (21%)