DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tobi and si:ch211-236l14.4

DIOPT Version :9

Sequence 1:	NP_651391.1	Gene:	tobi / 43072	FlyBaseID:	FBgn0261575	Length:	657	Species:	Drosophila melanogaster
Sequence 2:	XP_002666900.3	Gene:	si:ch211-236l14.4 / 797251	ZFINID:	ZDB-GENE-081104-189	Length:	693	Species:	Danio rerio

Alignment Length:	713	Identity:	177/713 - (24%)
Similarity:	295/713 - (41%)	Gaps:	131/713 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 CLWEAVHTCASIE----QRYKFPNSNVYVR--------LRRGDKLQYELMKGEKSLQTVTFDNFD 66
            ||..||....:|.    |....||.|..::        .||...|..:.:..:|:...:..:|.
Zfish    34 CLGVAVFFVMTIGIIYWQVVDQPNKNWILKGSFSGLIWERRTQTLVIQTLTEDKTFAEIDVENV- 97

  Fly    67 SSANLVETSSGSYQLTDGQSTVEFTLVKS------GVVAGTGSEITHVKVSRDQVLQGTQPRD-- 123
                             |.:.:|...|::      .....|...:..||:|    |:..:..|
Zfish    98 -----------------GNTDIEVPFVRNMCWLNKTEFCYTWDSVAEVKIS----LESEEDSDTE 141

  Fly   124 CVPLKTGSTH---------------WFSGPEQKQHYWPVERQRHSNYSYLPKELDNF-----GVG 168
            |..:.....|               |:.|...:...||:   .::|.|..|..:.:|     |.|
Zfish   142 CYSVTWTPIHCHVDLKDCFSMVNISWYGGASVRAPNWPI---NNANISMQPFTVSDFRDNPSGFG 203

  Fly   169 ---ERYWLNGDGVFLYVESNTPLFIDQNSAAYPDQLCLSAISALPYDPRVTSAKFVYHVAVAKDA 230
               |||:|...||.:.|..|.||.:...|   ..|.||..      .|.:......|.|.|..:.
Zfish   204 SVLERYFLGSSGVSVLVAPNIPLHVGMES---QQQFCLQT------PPSMERMPLQYTVCVGHNI 259

  Fly   231 KAAHRYAVKTFLGQPTGYPDERMVMHPVWSTWALYKAEVS-DDVVRDFAKQILDNGFNNSQLEID 294
            |..|:.:::.........|:..::..|.|...|...:... :..:|.|:.::..:......:.:|
Zfish   260 KVVHQESMRQLSTIRRELPNMDVLRLPFWKLLANVDSGAKLERELRTFSNRLKRHHLGEGIISLD 324

  Fly   295 DDWEDCYGAM--TFRKNKFPDSKTLTDDL---KALGFRVTLWIHPFINNNCTAIYDEAKSKGYLV 354
            :........|  ::...|...||..|.||   |.|...:||  .|:::         ..::.:..
Zfish   325 EHSTTLLTNMDHSYLNGKKRTSKRQTRDLPFVKLLNISITL--SPYLS---------VDTQQFQT 378

  Fly   355 LDHEGSSD-----------------TQWWNSKPKDAAILDFTKTEVQEWFSKRLKRLQDEDGIDS 402
            ...||..|                 |:|   |.|.:..|:.|..|...||..::..|....|::.
Zfish   379 SIQEGIEDYWLSLPSGPQGQLVPLLTRW---KGKYSVKLNITNPEATTWFLDKVDSLHSHLGMEY 440

  Fly   403 FKFDAGETSWLPSDPVLQASSSMVTPLQAVGD-YVRTVA----AFGDMVEVRSAQNTQDQPIFVR 462
            ...:.||     .:|.  ...::..||:.||| |:|.:|    ..||...|.|...:..:|:|:|
Zfish   441 VILEGGE-----GNPF--EEQALRPPLELVGDEYIRLLADLAERIGDNAIVTSGTRSSHKPLFIR 498

  Fly   463 IVDKDSEWGWNNGLLTLISSMLQMNLNGYPFVLPDMIGGNGYYEKPPTKELFLRWLQANVFMPAL 527
            :....|:|.: :||..:|.|:|..:|.||.|.:||.:||:...|.....|||:|||....|:|.:
Zfish   499 MSALQSDWSY-SGLKGIIPSLLHHSLLGYNFFIPDAVGGSLSPELVGDDELFIRWLGIAAFLPVI 562

  Fly   528 QFSFVPWNFDDE-AIAISKNFTALHATY-TPYIMKLFKRAVDSGEPVNVPLWWIAPTDEVAQSIY 590
            .|...||.|:.| .:.:::.:.|.|..: .|.|:|......::|.|:..||||::|.|.:..||.
Zfish   563 SFQTPPWVFEKEWVLNLTRFYIAKHHDFVVPLILKYADEWQETGNPIYRPLWWLSPNDPITFSID 627

  Fly   591 DEFLLGEDIIAAPVVVEGATKRDIYLPEG--EWQDGNSDQVYTGPTWVMDYAAPLDTLPYFLR 651
            ||||:|::::.|||..:|:..|||||||.  :|.|.|:.||:.|.|::.:|:..|..:|.|::
Zfish   628 DEFLIGDEVLVAPVTEKGSLHRDIYLPESDFQWLDTNNAQVFDGGTFLENYSVGLGDVPVFVQ 690

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tobi	NP_651391.1	Glyco_hydro_31	246..653	CDD:279404	122/438 (28%)
tobi	NP_651391.1	GH31_NET37	255..621	CDD:269878	110/397 (28%)
si:ch211-236l14.4	XP_002666900.3	AmyAc_family	360..655	CDD:298606	93/316 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582091
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1501
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D238940at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.840