DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tobi and SI

DIOPT Version :9

Sequence 1:	NP_651391.1	Gene:	tobi / 43072	FlyBaseID:	FBgn0261575	Length:	657	Species:	Drosophila melanogaster
Sequence 2:	NP_001032.2	Gene:	SI / 6476	HGNCID:	10856	Length:	1827	Species:	Homo sapiens

Alignment Length:	726	Identity:	147/726 - (20%)
Similarity:	252/726 - (34%)	Gaps:	192/726 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 QRYKFPNSNVYVRLRRGDKLQ---YELMKGEK--SLQTVTFDNFDSSANLVETSSGSYQLTDGQS 86
            :||:.|:.  ||:...|..:.   |::...:.  |:|.:...|   ...|.:||.|....:|...
Human   168 RRYEVPHQ--YVKEFTGPTVSDTLYDVKVAQNPFSIQVIRKSN---GKTLFDTSIGPLVYSDQYL 227

  Fly    87 TVEFTLVKSGVVAGTGSEITHVKVSRDQVLQGTQPRDCVPLKTGSTHWFSGPEQKQHYWPVERQR 151
            .:. |.:.|..:.|.|.:: |.:...|           :..||               ||:..:
Human   228 QIS-TRLPSDYIYGIGEQV-HKRFRHD-----------LSWKT---------------WPIFTR- 263

  Fly   152 HSNYSYLPKELDNFGVGERYWL--------NGDGVFLYVESNTPLFIDQNSAAYPDQLCLSAISA 208
                ..||.:.:|...|.:.:.        ...||||...:...:||.      |..:
Human   264 ----DQLPGDNNNNLYGHQTFFMCIEDTSGKSFGVFLMNSNAMEIFIQ------PTPI------- 311

  Fly   209 LPYDPRVTSAKFVYHVAVA-KDAKAAHRYAVKTFLGQPTGYPDERMVMHPVW------STWALYK 266
            :.|  |||.....:::.:. ...:...:|.      |..|.|    .|...|      |.|. ||
Human   312 VTY--RVTGGILDFYILLGDTPEQVVQQYQ------QLVGLP----AMPAYWNLGFQLSRWN-YK 363

  Fly   267 AEVSDDVVRDFAKQILDNG--FNNSQLEID--DDWEDCYGAMTFRKNKFPDSKTLTDDLKALGFR 327
               |.|||::..::..:.|  |:....:||  :|.:|    .|:.:..|........||...|.:
Human   364 ---SLDVVKEVVRRNREAGIPFDTQVTDIDYMEDKKD----FTYDQVAFNGLPQFVQDLHDHGQK 421

  Fly   328 VTLWIHPFI------NNNCTAIYDEAKSKGYLVLDHEGSSDT--QWWNSKPKDAAILDFTKTEVQ 384
            ..:.:.|.|      |....|.|:...::...:.:.:||:..  :.|   |......|||.....
Human   422 YVIILDPAISIGRRANGTTYATYERGNTQHVWINESDGSTPIIGEVW---PGLTVYPDFTNPNCI 483

  Fly   385 EWFSKRLKRLQDEDGIDSFKFDAGETS-------------------WLPS--DPVLQASSSMVTP 428
            :|::........|...|....|..|.|                   :.|.  |.::.:.:..:..
Human   484 DWWANECSIFHQEVQYDGLWIDMNEVSSFIQGSTKGCNVNKLNYPPFTPDILDKLMYSKTICMDA 548

  Fly   429 LQAVGDYVRTVAAFGDMVEVRSAQNTQ----DQPIFVR---------------IVDKDSEW---G 471
            :|..|......:.:|..:.:.:.|..|    ::..|:.               :.|..:.|   .
Human   549 VQNWGKQYDVHSLYGYSMAIATEQAVQKVFPNKRSFILTRSTFAGSGRHAAHWLGDNTASWEQME 613

  Fly   472 WNNGLLTLISSMLQMNLNGYPFVLPDMIGGNGYYEKPPTKELFLRWLQANVFMPALQFS------ 530
            |:      |:.||:.:|.|.|.|..|:.|    :....|:||..||:|...|.|   ||
Human   614 WS------ITGMLEFSLFGIPLVGADICG----FVAETTEELCRRWMQLGAFYP---FSRNHNSD 665

  Fly   531 ----FVPWNFDDEAIAI--SKNFTALHATYTPYIMKLFKRAVDSGEPVNVPLW---------WIA 580
                ..|..|...::.:  |:.:..:..|..|::..||.:|...||.|..|:.         ||.
Human   666 GYEHQDPAFFGQNSLLVKSSRQYLTIRYTLLPFLYTLFYKAHVFGETVARPVLHEFYEDTNSWIE 730

  Fly   581 PTDEVAQSIYDEFLLGEDIIAAPVVVEGATKRDIYLPEGEWQDGNSDQVYTGPTWVMDYAAPLDT 645
            .|         |||.|..::..||:.:||.....|:|:..|.|..|..........:|...|.|.
Human   731 DT---------EFLWGPALLITPVLKQGADTVSAYIPDAIWYDYESGAKRPWRKQRVDMYLPADK 786

  Fly   646 LPYFLRVGFTL 656
            :...||.|:.:
Human   787 IGLHLRGGYII 797

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tobi	NP_651391.1	Glyco_hydro_31	246..653	CDD:279404	104/488 (21%)
tobi	NP_651391.1	GH31_NET37	255..621	CDD:269878	94/447 (21%)
SI	NP_001032.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	40..61
		PD	70..112	CDD:197472
		Isomaltase	110..1007		147/726 (20%)
		NtCtMGAM_N	125..234	CDD:293468	16/71 (23%)
		GH31_N	227..333	CDD:270212	25/153 (16%)
		Glyco_hydro_31	324..797	CDD:279404	107/515 (21%)
		GH31_MGAM_SI_GAA	343..707	CDD:269888	78/391 (20%)
		PD	935..980	CDD:197472
		NtCtMGAM_N	994..1107	CDD:293468
		Sucrase	1008..1827
		GH31_N	1100..1214	CDD:270212
		Glyco_hydro_31	1195..1691	CDD:279404
		GH31_MGAM_SI_GAA	1214..1601	CDD:269888
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148169
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1501
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740