DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tobi and MYORG

DIOPT Version :9

Sequence 1:	NP_651391.1	Gene:	tobi / 43072	FlyBaseID:	FBgn0261575	Length:	657	Species:	Drosophila melanogaster
Sequence 2:	NP_065753.2	Gene:	MYORG / 57462	HGNCID:	19918	Length:	714	Species:	Homo sapiens

Alignment Length:	701	Identity:	223/701 - (31%)
Similarity:	337/701 - (48%)	Gaps:	112/701 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LSLLLASFCLWEAVHTCASIEQRYKFPNSNVYVRLRRGDKLQYELMKGEKSLQTVTFDNFDSSAN 70
            |.|:||:...|     |     .|.       |.||:.::|:                     |.
Human    65 LLLVLAAVVAW-----C-----YYS-------VSLRKAERLR---------------------AE 91

  Fly    71 LVETSSGSYQLTDGQSTVEFTLV-KSGVV---------AGTGSEITHVKVSRDQVLQGTQPRDCV 125
            |::..:|.:.:.:.:....|.|. :||.:         |..|..:|...:.....:|..:|:|.|
Human    92 LLDLKAGGFSIRNQKGEQVFRLAFRSGALDLDSCSRDGALLGCSLTADGLPLHFFIQTVRPKDTV 156

  Fly   126 P--------------------LKTGSTHWFSGPEQKQHYWPV------ERQRHSNYSYLPKELDN 164
            .                    |...:.||:.|.|.:..:||:      |.|..........:...
Human   157 MCYRVRWEEAAPGRAVEHAMFLGDAAAHWYGGAEMRTQHWPIRLDGQQEPQPFVTSDVYSSDAAF 221

  Fly   165 FGVGERYWLNGDGVFLYVESNTPLFIDQNS--------AAYPDQLCLSAISALPYDP---RVTSA 218
            .|:.|||||:.....:.|..:.|..:..||        |.|.|         .||.|   |..:.
Human   222 GGILERYWLSSRAAAIKVNDSVPFHLGWNSTERSLRLQARYHD---------TPYKPPAGRAAAP 277

  Fly   219 KFVYHVAVAKDAKAAHRYAVKTFLGQPTGYPDERMVMHPVWSTWALYKAEVSDDVVRDFAKQILD 283
            :..|.|.|..|..:.|:|.|:.:..:|:..|.......|:|||||||...|..|.|..||:||..
Human   278 ELSYRVCVGSDVTSIHKYMVRRYFNKPSRVPAPEAFRDPIWSTWALYGRAVDQDKVLRFAQQIRL 342

  Fly   284 NGFNNSQLEIDDDWEDCYGAMTFRKNKFPDSKTLTDDLKALGFRVTLWIHPFINNNCTAIYDEAK 348
            :.||:|.|||||.:...||...|.:.|||::..:...|:..|||||||:|||:|.| ::.:.|..
Human   343 HHFNSSHLEIDDMYTPAYGDFDFDEVKFPNASDMFRRLRDAGFRVTLWVHPFVNYN-SSRFGEGV 406

  Fly   349 SKGYLVLDHEG--SSDTQWWNSKPKDAAILDFTKTEVQEWFSKRLKRLQDEDGIDSFKFDAGETS 411
            .:...|.:..|  .:..:|||.   ..|:||||..:.::||...|:||:....:.||||||||.|
Human   407 ERELFVREPTGRLPALVRWWNG---IGAVLDFTHPKARDWFQGHLRRLRSRYSVASFKFDAGEVS 468

  Fly   412 WLPSDPVLQASSSMVTPLQAVGD--YVRTVAAFGDMVEVRSAQNTQDQPIFVRIVDKDSEWGWNN 474
            :||.|    .|:....|..:|..  |......|..:.|||....:|:...|.|:||:||.||::.
Human   469 YLPRD----FSTYRPLPDPSVWSRRYTEMALPFFSLAEVRVGYQSQNISCFFRLVDRDSVWGYDL 529

  Fly   475 GLLTLISSMLQMNLNGYPFVLPDMIGGNGYYEKP-----PTKELFLRWLQANVFMPALQFSFVPW 534
            ||.:||.::|.:::.||||:||||:|||...::.     |.:||::|||:...||||:|||..||
Human   530 GLRSLIPAVLTVSMLGYPFILPDMVGGNAVPQRTAGGDVPERELYIRWLEVAAFMPAMQFSIPPW 594

  Fly   535 NFDDEAIAISKNFTALHAT-YTPYIMKLFKRAVDSGEPVNVPLWWIAPTDEVAQSIYDEFLLGED 598
            .:|.|.:||::.|.||.|: ..|.:::|.....|:|:|:..|||||||.||.|..|..:||:|:.
Human   595 RYDAEVVAIAQKFAALRASLVAPLLLELAGEVTDTGDPIVRPLWWIAPGDETAHRIDSQFLIGDT 659

  Fly   599 IIAAPVVVEGATKRDIYLPEGEWQDGNSDQVYTGPTWVMDYAAPLDTLPYF 649
            ::.|||:..|..:||:|||.|:|:....:.....|..:.||...||.:.||
Human   660 LLVAPVLEPGKQERDVYLPAGKWRSYKGELFDKTPVLLTDYPVDLDEIAYF 710

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tobi	NP_651391.1	Glyco_hydro_31	246..653	CDD:279404	164/414 (40%)
tobi	NP_651391.1	GH31_NET37	255..621	CDD:269878	155/375 (41%)
MYORG	NP_065753.2	GH31_NET37	314..682	CDD:269878	155/375 (41%)
MYORG	NP_065753.2	Glyco_hydro_31	329..707	CDD:279404	152/385 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148171
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1501
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	362	1.000	Inparanoid score	I2196
Isobase	1	0.950	-	0	Normalized mean entropy	S5596
OMA	1	1.010	-	-		QHG48838
OrthoDB	1	1.010	-	-		D238940at2759
OrthoFinder	1	1.000	-	-		FOG0004094
OrthoInspector	1	1.000	-	-		oto88400
orthoMCL	1	0.900	-	-		OOG6_103615
Panther	1	1.100	-	-	LDO	PTHR43053
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5348
SonicParanoid	1	1.000	-	-		X4465
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.750