DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tobi and Si

DIOPT Version :9

Sequence 1:	NP_651391.1	Gene:	tobi / 43072	FlyBaseID:	FBgn0261575	Length:	657	Species:	Drosophila melanogaster
Sequence 2:	NP_001376155.1	Gene:	Si / 497756	RGDID:	3675	Length:	1836	Species:	Rattus norvegicus

Alignment Length:	830	Identity:	163/830 - (19%)
Similarity:	262/830 - (31%)	Gaps:	286/830 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 CLWEAV-----------------HTCASIE----------------QRYKFPNS-----NVYVRL 40
            |||:.|                 :|..||:                .|.|.|::     .|.|:.
  Rat   970 CLWQPVSGLSNVPPCYFPPEHNPYTLTSIQPLPTGITAELQLNPANARIKLPSNPISTLRVEVKY 1034

  Fly    41 RRGDKLQYELMKGEKSL----------QTVTFDN---FD---------------SSANLV-ETSS 76
            .:.|.||:::...:...          .|.|..|   :|               ||..|: ::|.
  Rat  1035 HKNDMLQFKIYDAQHKRYEVPVPLNIPDTPTSSNERLYDVEIKENPFGIQVRRRSSGKLIWDSSL 1099

  Fly    77 GSYQLTDGQSTVEFTLVKSGVVAGTGSEITHVKVSRDQVLQGTQPRDCVPLKTGSTHWFSGPEQK 141
            ..:...| |.....|.:.|..:.|.| |:.|....||                  .:|
  Rat  1100 PGFAFND-QFIQISTRLPSNYLYGFG-EVEHTAFKRD------------------LNW------- 1137

  Fly   142 QHYWPV-ERQRHSNYSYLPKELDNFGVGERYWL-----NGDGVFLYVESNTPLFIDQNSAAYPDQ 200
             |.|.: .|.:...|     :|:::|....|..     |..||.| :.||.   :|......|
  Rat  1138 -HTWGMFTRDQPPGY-----KLNSYGFHPYYMALENEGNAHGVLL-LNSNG---MDVTFQPTP-- 1190

  Fly   201 LCLSAISALPYDPRVTSAKFVYHVAVAKDAKAAHRYAVKTFLGQPTGYPDERMVMHPVWSTWALY 265
                   ||.|  |.......:::.:....:.|.|.     ..:..|:|    ||.|.|:
  Rat  1191 -------ALTY--RTIGGILDFYMFLGPTPEIATRQ-----YHEVIGFP----VMPPYWA----- 1232

  Fly   266 KAEVSDDVVRDFAKQILDNGFNNSQLEIDDDWEDCYGAMTFRKNKFPD---------------SK 315
                       ...|:...|:.|:. ||:..:.|...|......::.|               .|
  Rat  1233 -----------LGFQLCRYGYRNTS-EIEQLYNDMVAANIPYDVQYTDINYMERQLDFTIGERFK 1285

  Fly   316 TL---TDDLKALGFRVTLWIHPFINNNCTAIYDEAKSKGY---LVLDHEGSSDTQW---W----- 366
            ||   .|.::..|.:..:.:.|.|:.|.|..| .|..:|.   :.:....::|..|   |
  Rat  1286 TLPEFVDRIRKDGMKYIVILDPAISGNETQPY-PAFERGIQKDVFVKWPNTNDICWAKVWPDLPN 1349

  Fly   367 -------------NSKPKDAAILDFTKTEVQEWFSKRLKRLQDEDGIDSFKFDA----------- 407
                         |:.....|..||.:....||:::.:....:|    ..|||.
  Rat  1350 VTIDETITEDEAVNASRAHVAFPDFFRNSTLEWWAREIYDFYNE----KMKFDGLWIDMNEPSSF 1410

  Fly   408 --------------------------GE-----TSWLPSDPVLQASSSMV----------TPLQA 431
                                      ||     |..:.::.:|...||::          :.::.
  Rat  1411 VNGTVTNKCRNDTLNYPPYFPELTKRGEGLHFRTMCMETEHILSDGSSVLHYDVHNLYGWSQVKP 1475

  Fly   432 VGDYVRTVAAFGDMVEVRSAQNTQDQPIFVRIVDKDSEWG----------WNNGLLTLISSMLQM 486
            ..|.::.......:|..||...|.            ..||          |:|...:|| .||:.
  Rat  1476 TLDALQNTTGLRGIVISRSTYPTA------------GRWGGHWLGDNYANWDNLEKSLI-GMLEF 1527

  Fly   487 NLNGYPFVLPDMIGGNGYYEKPPTKELFLRWLQANVFMP-----ALQFSF----VPWNFDDEAIA 542
            ||.|.|::..|:.|    :.......|..||:|...|.|     .:||:.    |.||   |..|
  Rat  1528 NLFGIPYIGADICG----FFNDSEYHLCTRWMQVGAFYPYSRNHNIQFTRRQDPVSWN---ETFA 1585

  Fly   543 -ISKNFTALHATYTPYIMKLFKRAVDSGEPVNVPLWWIAPTDEVAQSIYDEFLLGEDIIAAPVVV 606
             :||....:..|..||.......|...|..|..||......|:....||.:||.|...:..|||.
  Rat  1586 QMSKKVLEIRYTLLPYFYTQMHEAHAQGGTVIRPLMHEFFDDKETWEIYKQFLWGPAFMVTPVVE 1650

  Fly   607 EGATKRDIYLPEGEWQDGNSDQVYTGPTWVMDYAAPLDTLPYFLRVGFTL 656
            ...|....|:|:..|.|.::.:.......:..::||.||:...:|.|:.|
  Rat  1651 PFRTSVTGYVPKARWFDYHTGEDIKLKGILHTFSAPFDTINLHVRGGYIL 1700

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tobi	NP_651391.1	Glyco_hydro_31	246..653	CDD:279404	106/520 (20%)
tobi	NP_651391.1	GH31_NET37	255..621	CDD:269878	96/479 (20%)
Si	NP_001376155.1	Trefoil	80..118	CDD:395041
		NtCtMGAM_N	135..244	CDD:407105
		GH31_N	237..353	CDD:270212
		GH31_MGAM_SI_GAA	353..717	CDD:269888
		PD	944..990	CDD:197472	4/19 (21%)
		NtCtMGAM_N	1004..1116	CDD:407105	19/112 (17%)
		GH31_N	1109..1223	CDD:270212	30/165 (18%)
		Glyco_hydro_31	1204..1700	CDD:395838	109/546 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342038
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840