DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tobi and GAA

DIOPT Version :9

Sequence 1:	NP_651391.1	Gene:	tobi / 43072	FlyBaseID:	FBgn0261575	Length:	657	Species:	Drosophila melanogaster
Sequence 2:	NP_000143.2	Gene:	GAA / 2548	HGNCID:	4065	Length:	952	Species:	Homo sapiens

Alignment Length:	700	Identity:	149/700 - (21%)
Similarity:	234/700 - (33%)	Gaps:	200/700 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 PRDCVPLK-------TGSTHW-FSGPEQKQHYWPVERQR-HSN-----YSYLPKELDNFGVGERY 171
            |:|.:.|:       ....|: ...|..:::..|:|... ||.     ||....| :.|||..|.
Human   161 PKDILTLRLDVMMETENRLHFTIKDPANRRYEVPLETPHVHSRAPSPLYSVEFSE-EPFGVIVRR 224

  Fly   172 WLNGDGVFLYVESNTPLFID----QNSAAYPDQLCLSAISALPYDPRVTSAKFV----------- 221
            .|  ||..|...:..|||..    |.|.:.|.|........|  .|.:.|..:.
Human   225 QL--DGRVLLNTTVAPLFFADQFLQLSTSLPSQYITGLAEHL--SPLMLSTSWTRITLWNRDLAP 285

  Fly   222 -----------YHVAVAKDAKAAHR---------------------------YAVKTFLG-QP-- 245
                       :::|: :|..:||.                           ..|..||| :|
Human   286 TPGANLYGSHPFYLAL-EDGGSAHGVFLLNSNAMDVVLQPSPALSWRSTGGILDVYIFLGPEPKS 349

  Fly   246 --------TGYPDERMVMHPVWS------TWALYKAEVSDDVVRDFAKQ--ILDNGFNNSQLEID 294
                    .|||    .|.|.|.      .|......::..||.:..:.  .||..:|      |
Human   350 VVQQYLDVVGYP----FMPPYWGLGFHLCRWGYSSTAITRQVVENMTRAHFPLDVQWN------D 404

  Fly   295 DDWEDCYGAMTFRKNKFPDSKTLTDDLKALGFRVTLWIHPFINNNCTA----IYDEAKSKGYLVL 355
            .|:.|.....||.|:.|.|...:..:|...|.|..:.:.|.|:::..|    .|||...:|..:.
Human   405 LDYMDSRRDFTFNKDGFRDFPAMVQELHQGGRRYMMIVDPAISSSGPAGSYRPYDEGLRRGVFIT 469

  Fly   356 DHEGSS--DTQWWNSKPKDAAILDFTKTEVQEWFSKRLKRLQDEDGIDSFKFDAGETS------- 411
            :..|..  ...|    |...|..|||......|:...:....|:...|....|..|.|
Human   470 NETGQPLIGKVW----PGSTAFPDFTNPTALAWWEDMVAEFHDQVPFDGMWIDMNEPSNFIRGSE 530

  Fly   412 ------------WLPS--DPVLQASSSMVTPLQAVGDY---------VRTVAAFGDMVEVRSAQN 453
                        ::|.  ...|||::...:..|.:..:         ...:|:...:|:.|..
Human   531 DGCPNNELENPPYVPGVVGGTLQAATICASSHQFLSTHYNLHNLYGLTEAIASHRALVKARGT-- 593

  Fly   454 TQDQPIFVRIVDKDS---------EW------GWNNGLLTLISSMLQMNLNGYPFVLPDMIG--G 501
               :|.   ::.:.:         .|      .|.. |.:.:..:||.||.|.|.|..|:.|  |
Human   594 ---RPF---VISRSTFAGHGRYAGHWTGDVWSSWEQ-LASSVPEILQFNLLGVPLVGADVCGFLG 651

  Fly   502 NGYYEKPPTKELFLRWLQANVFMP-------ALQFSFVPWNFDDEAIAISKNFTALHATYTPYIM 559
            |      .::||.:||.|...|.|       .|.....|::|.:.|....:....|.....|::.
Human   652 N------TSEELCVRWTQLGAFYPFMRNHNSLLSLPQEPYSFSEPAQQAMRKALTLRYALLPHLY 710

  Fly   560 KLFKRAVDSGEPVNVPLWWIAPTDEVAQSIYDEFLLGEDIIAAPVVVEGATKRDIYLPEGEWQD- 623
            .||.:|..:||.|..||:...|.|....::..:.|.||.::..||:..|..:...|.|.|.|.|
Human   711 TLFHQAHVAGETVARPLFLEFPKDSSTWTVDHQLLWGEALLITPVLQAGKAEVTGYFPLGTWYDL 775

  Fly   624 -----------------GNSDQVYTGPTWVMDYAAPLDTLPYFLRVGFTL 656
                             .....:::...|| ...|||||:...||.|:.:
Human   776 QTVPVEALGSLPPPPAAPREPAIHSEGQWV-TLPAPLDTINVHLRAGYII 824

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tobi	NP_651391.1	Glyco_hydro_31	246..653	CDD:279404	109/492 (22%)
tobi	NP_651391.1	GH31_NET37	255..621	CDD:269878	95/433 (22%)
GAA	NP_000143.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	47..82
		PD	81..132	CDD:197472
		NtCtMGAM_N	159..253	CDD:318956	25/94 (27%)
		GH31_N	246..359	CDD:270212	16/115 (14%)
		Glyco_hydro_31	340..824	CDD:307274	114/513 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148167
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1501
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740