DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tobi and Ganc

DIOPT Version :9

Sequence 1:	NP_651391.1	Gene:	tobi / 43072	FlyBaseID:	FBgn0261575	Length:	657	Species:	Drosophila melanogaster
Sequence 2:	NP_001139312.1	Gene:	Ganc / 24382	RGDID:	2660	Length:	913	Species:	Rattus norvegicus

Alignment Length:	759	Identity:	163/759 - (21%)
Similarity:	269/759 - (35%)	Gaps:	205/759 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 IEQRYKFP---NSNV-YVRL-------------RRGD--------KLQYELMKGEKSLQTVT--- 61
            ::.||:.|   ||.: .|||             |:||        ..:.:|:..:::|.::.
  Rat    92 LKPRYEVPDVVNSKLGTVRLVCSGDTGSLTLTDRKGDLRCHISANPFKIDLLSKDEALISINSLG 156

  Fly    62 ---FDNFDSSANLVETSSGSYQLTDGQSTVEFTLVKSGVVAGTGSE----ITHVKVSRDQVLQGT 119
               |::.........|..      :||:|...|..::....|...|    ...|||:.
  Rat   157 KLYFEHLRVPHKQRATKG------NGQNTPADTFQENQEDLGLWEEKFGKFVDVKVNG------- 208

  Fly   120 QPRDCVPLKTG---STHWFSGPEQKQHYWPVERQRHSNYSYLPKELDNFGVGERYWLNGDGVFLY 181
                  |...|   |.|.|      :|.:.:.:...|:      :|.|...|:.|.|....|:.|
  Rat   209 ------PSSVGLDFSLHGF------EHLYGIPQHAESH------QLKNTRDGDAYRLYNLDVYGY 255

  Fly   182 -------VESNTPLFIDQNSAAYPDQLCLSAISALPYDPRVTSAKFVYHVAVAKDAKAAHRYAVK 239
                   :..:.|..:............|:|...|.......:|:  |.:.....|.|..:...:
  Rat   256 QVHDKMGIYGSVPYLLAHKQGRTVGIFWLNASETLVEINTEPAAE--YTLTQMGPAAAKQKVRCR 318

  Fly   240 T--------------FLGQPT--------GYPDERMVMHPVWS------TWALYKAEVSDDVVRD 276
            |              .|..||        .|......|.|::|      .|   ..|...||
  Rat   319 TNVHWMSESGIIDVFLLTGPTPADIFKQYSYITGTQAMPPLFSLGYHQCRW---NYEDEQDV--- 377

  Fly   277 FAKQILDNGFNNSQLEIDDDWEDCYGA-----MTFRKNKFPDSKTLTDDLKALGFRVTLWIHPFI 336
               :.:|.||:...:..|..|.|....     .|:.|.:|.:.|.:.:.|::.|.::.:...|.|
  Rat   378 ---KAVDAGFDEHDIPYDVMWLDIEHTEDKKYFTWDKKRFANPKRMQELLRSKGRKLVVISDPHI 439

  Fly   337 N-NNCTAIYDEAKSKGYLVLDHEGSS-DTQWWNSKPKDAAILDFTKTEVQEWFSKRLKRLQDEDG 399
            . :....:|.|||.:|:.|.:.||.. :...|   |..::.||||..:|:||:|          .
  Rat   440 KVDPDYTVYAEAKERGFFVKNPEGGDLEGVCW---PGLSSYLDFTNPKVREWYS----------S 491

  Fly   400 IDSFKFDAGETSWL-----PSDPVLQASSSMVTPLQAV--------------GDYVRTVAAFGDM 445
            :.:|....|.|..|     .::|.:.....:.....||              |.|.:...|.|
  Rat   492 LFAFPVYQGSTDILFLWNDMNEPSVFRGPELTMQKNAVHHGNWEHRELHNIYGFYHQMATAEG-- 554

  Fly   446 VEVRSAQNTQDQPIFVRIV-------------DKDSEWGWNNGLLTLISSMLQMNLNGYPFVLPD 497
             .::.:|..:...:..|..             |..:||.:   |...|..:|.::::|..|...|
  Rat   555 -LIQRSQGKERPFVLSRSFFAGSQKYGAVWTGDNTAEWSY---LKISIPMLLTLSVSGISFCGAD 615

  Fly   498 MIG--GNGYYEKPPTKELFLRWLQANVFMPALQFSFV-------PWNFDDEAIAISKNFTALHAT 553
            :.|  ||      |..||.:||.||..:.|..:....       ||.|..|...:.:.  |:...
  Rat   616 VGGFIGN------PEAELLVRWYQAAAYQPFFRGHATMNTKRREPWLFGAEYTQLIRE--AIRER 672

  Fly   554 YT--PYIMKLFKRAVDSGEPVNVPLWWIAPTDEVAQSIYDEFLLGEDIIAAPVVVEGATKRDIYL 616
            |:  ||:..||..|..|.:||..|||...|.|....::.||::||..::..||.....|..|::|
  Rat   673 YSLLPYLYSLFYHAHVSSQPVMRPLWVEFPDDLETFAVEDEYMLGNALLVHPVTAPQTTMIDVFL 737

  Fly   617 PEGEWQDGNSDQVYTGPT---W----VMDYAAPLDTLPYFLRVG 653
            |      |:::..|...|   |    .:.....|||:|.|.|.|
  Rat   738 P------GSNEVWYNSKTFAYWKGGCAVKVPVTLDTIPVFQRGG 775

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tobi	NP_651391.1	Glyco_hydro_31	246..653	CDD:279404	113/477 (24%)
tobi	NP_651391.1	GH31_NET37	255..621	CDD:269878	101/421 (24%)
Ganc	NP_001139312.1	GH31_N	212..352	CDD:270212	26/153 (17%)
		Glyco_hydro_31	333..778	CDD:279404	116/485 (24%)
		GH31_GANC_GANAB_alpha	352..819	CDD:269889	112/466 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342041
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1501
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740