DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tobi and Mgam

DIOPT Version :9

Sequence 1:	NP_651391.1	Gene:	tobi / 43072	FlyBaseID:	FBgn0261575	Length:	657	Species:	Drosophila melanogaster
Sequence 2:	NP_001355804.1	Gene:	Mgam / 232714	MGIID:	1203495	Length:	3616	Species:	Mus musculus

Alignment Length:	815	Identity:	168/815 - (20%)
Similarity:	265/815 - (32%)	Gaps:	252/815 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 CLWE-----AVHTCASIEQRYK-------------------------FPNSNV-----YVRLRRG 43
            |:||     .|..|..:.:.|.                         ||::.|     .|...:.
Mouse  2746 CVWEESNSDVVPFCYFVNELYSVSNVQYGSHGATANISLKASPYSGAFPSTPVKELQLQVTYHKN 2810

  Fly    44 DKLQYELMKGEKSLQTVTFD-NFDSSANLVETSSGSYQLTDGQSTVEFTLVKSGVVA------GT 101
            :.||:::.....|...|... |..|:    .:|:...:|.|       .|:|.....      ||
Mouse  2811 EMLQFKIYDPNHSRYEVPVPLNIPSA----PSSTPESRLYD-------VLIKENPFGIEIRRKGT 2864

  Fly   102 GSEITHVKVSRDQVLQGTQPRDC---VPLKTGSTHWFSGPEQKQHYWPVERQRHSNYSYLPKELD 163
            |:      |..|..|.|....|.   :..:..||:.:...|.:          |:.:. :....:
Mouse  2865 GT------VVWDSQLLGFTFSDMFIRISTRLPSTYIYGFGETE----------HTTFK-IDMNWN 2912

  Fly   164 NFGVGER-----YWLNGDGVFLYV-----ESNTPLFIDQNSAAYPDQLCLSAISALPYDPRVTSA 218
            .:|:..|     |..|..||..|.     :.|....:..||.|.  .:....:.||.|  |.|..
Mouse  2913 KWGMFSRDEPPGYRKNSYGVHPYYMGLEEDGNAHGVLLMNSNAM--DVTFQPMPALTY--RTTGG 2973

  Fly   219 KFVYHVAVAKDAK-AAHRYAVKTFLGQPTGYPDERMVMHPVWSTW---------------ALYKA 267
            ...::|.:....: ...:|.  ..:|:|        ||.|.||..               :||..
Mouse  2974 ILDFYVFLGPTPEFVTQQYT--ELIGRP--------VMVPYWSLGFQLCRYGYENDSEIASLYDE 3028

  Fly   268 EVSDDVVRDFAKQILDNGFNNSQLEIDDDWEDCYGAMTFRKN-KFPDSKTLTDDLKALGFRVTLW 331
            .|...:..|.  |..|..:...||:             |:.: ||.....|.:.:||.|.||.|.
Mouse  3029 MVDKKIPYDV--QYSDIDYMERQLD-------------FKLSPKFSGFPALINRMKANGMRVILI 3078

  Fly   332 IHPFINNNCTAIYDEAKSKGY---LVLDHEGSSDTQW---WNSKPK------------------D 372
            :.|.|:.|.|..| .|.::|.   :.:.:..:....|   |...|.                  .
Mouse  3079 LDPAISGNETEPY-PAFTRGVENDVFIRYPNNGSIVWGKVWPDYPNITVDPSLGWDHQVEQYRAY 3142

  Fly   373 AAILDFTKTEVQEWFSKRLKRLQD--EDGIDSFKFDAGETSWL---------------------- 413
            .|..||.:.....|:.|.:|.|..  :|...|.|||.   .|:
Mouse  3143 VAFPDFFRNSTATWWKKEIKELHSNTQDPAKSLKFDG---LWIDMNEPSSFVNGAVPSGCSDATL 3204

  Fly   414 ---PSDPVLQAS----SSMVTPLQAVGDYVRTVAAFGDMVEVRSAQN----TQDQPIFVRIVDKD 467
               |..|.|:|.    ||....:::     ..:...|..|......|    :|.:|.:..:.:..
Mouse  3205 NHPPYMPYLEARDRGLSSKTLCMES-----EQILPDGSRVRHYDVHNLYGWSQTRPTYEAVQEVT 3264

  Fly   468 SE---------------WG----------WNNGLLTLISSMLQMNLNGYPFVLPDMIGGNGYYEK 507
            .|               ||          |:. |...|..|:..:|.|..:...|:.|    :.:
Mouse  3265 GERGIVITRSTFPSSGRWGGHWLGDNTAAWDQ-LGKSIIGMMDFSLFGISYTGSDICG----FFQ 3324

  Fly   508 PPTKELFLRWLQANVFMPALQFSF------------VPWN--FDDEAIAISKNFTALHATYTPYI 558
            ....|:.:||:|...|.|   ||.            |.||  |:|    ||::......|..||:
Mouse  3325 DAEYEMCVRWMQLGAFYP---FSRNHNTIGTRRQDPVSWNKTFED----ISRSVLETRYTLLPYL 3382

  Fly   559 MKLFKRAVDSGEPVNVPLWWIAPTDEVAQSIYDEFLLGEDIIAAPVVVEGATKRDIYLPEGEWQD 623
            ..|..:|...|..|..||.....:|....:|..:||||...:.:||:...|.|.:.|.|...|.|
Mouse  3383 YTLMYKAHTEGSTVVRPLLHEFVSDRETWNIDKQFLLGPAFLVSPVLEPNARKVEAYFPRARWYD 3447

  Fly   624 --GNSDQVYTGPTWVMDYAAPLDTLPYFLRVGFTL 656
              ...|...||....::  |||:.:...:|.|:.|
Mouse  3448 YYKGVDINATGEWKTLE--APLEYINLHIRGGYIL 3480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tobi	NP_651391.1	Glyco_hydro_31	246..653	CDD:279404	113/522 (22%)
tobi	NP_651391.1	GH31_NET37	255..621	CDD:269878	103/479 (22%)
Mgam	NP_001355804.1	Trefoil	65..107	CDD:365865
		NtCtMGAM_N	124..233	CDD:374852
		GH31_N	226..342	CDD:270212
		GH31_MGAM_SI_GAA	342..705	CDD:269888
		PD	934..972	CDD:197472
		NtCtMGAM_N	988..1101	CDD:374852
		GH31_N	1087..1208	CDD:270212
		Glyco_hydro_31	1189..1690	CDD:376446
		Trefoil	1828..1867	CDD:238059
		NtCtMGAM_N	1883..1996	CDD:374852
		GH31_N	1982..2103	CDD:270212
		GH31_MGAM_SI_GAA	2103..2496	CDD:269888
		PD	2720..2764	CDD:197472	5/17 (29%)
		NtCtMGAM_N	2777..2890	CDD:374852	23/129 (18%)
		GH31_N	2876..2997	CDD:270212	23/137 (17%)
		Glyco_hydro_31	2978..3480	CDD:376446	118/549 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838268
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1501
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740