DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tobi and GANAB

DIOPT Version :9

Sequence 1:	NP_651391.1	Gene:	tobi / 43072	FlyBaseID:	FBgn0261575	Length:	657	Species:	Drosophila melanogaster
Sequence 2:	NP_938149.2	Gene:	GANAB / 23193	HGNCID:	4138	Length:	966	Species:	Homo sapiens

Alignment Length:	687	Identity:	159/687 - (23%)
Similarity:	246/687 - (35%)	Gaps:	159/687 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 RRGDKLQYELMKGEKSLQTVTFDNFDSSANLVETSSGSYQLTDGQSTVEFTLVKSGVVAGTGSEI 105
            |.|||.:....|.||.......:.|       :|.|.|.........::|:|.....|.|...
Human   228 RDGDKPEETQGKAEKDEPGAWEETF-------KTHSDSKPYGPMSVGLDFSLPGMEHVYGIPE-- 283

  Fly   106 THVKVSRDQVLQGTQPRDCVPLKTGSTHWFSGPEQKQHYWPVERQRHSNYSYLPKEL-----DNF 165
             |....|.:|.:|.:|.....|..         .|.:.|.|:     :.|..:|..|     .:.
Human   284 -HADNLRLKVTEGGEPYRLYNLDV---------FQYELYNPM-----ALYGSVPVLLAHNPHRDL 333

  Fly   166 GVGERYWLNGDGVFLYVESNT---PLF---ID--QNSAAYPDQLCLSAISALPYDPRVTSAKFVY 222
            |:   :|||....::.:.|||   .||   :|  |.|...|..           |.|..|...:.
Human   334 GI---FWLNAAETWVDISSNTAGKTLFGKMMDYLQGSGETPQT-----------DVRWMSETGII 384

  Fly   223 HVAVAKDAKAA---HRYAVKTFLGQPT-------GYPDERMVMHPVWSTWALYKAEVSDDVVRDF 277
            .|.:......:   .:||..|  |...       ||...|      |:    |:.|.  ||:.
Human   385 DVFLLLGPSISDVFRQYASLT--GTQALPPLFSLGYHQSR------WN----YRDEA--DVLE-- 433

  Fly   278 AKQILDNGFNNSQLEIDDDWEDCYGA-----MTFRKNKFPDSKTLTDDLKALGFRVTLWIHPFIN 337
                :|.||::..|..|..|.|...|     .|:..::||..:|:.:.|.:...::...:.|.|.
Human   434 ----VDQGFDDHNLPCDVIWLDIEHADGKRYFTWDPSRFPQPRTMLERLASKRRKLVAIVDPHIK 494

  Fly   338 -NNCTAIYDEAKSKGYLVLDHEGSSDTQW-WNSKPKDAAILDFTKTEVQEWFSKRLKRLQDEDGI 400
             ::...:::|.::.|..|...:||....| |   |..|...|||...::.|::
Human   495 VDSGYRVHEELRNLGLYVKTRDGSDYEGWCW---PGSAGYPDFTNPTMRAWWA------------ 544

  Fly   401 DSFKFDAGETS------WLPSDPVLQASSSMVTPLQ---------------AVGDYVRTVAAFGD 444
            :.|.:|..|.|      |...:.....:...||.|:               ..|.||....|.|
Human   545 NMFSYDNYEGSAPNLFVWNDMNEPSVFNGPEVTMLKDAQHYGGWEHRDVHNIYGLYVHMATADG- 608

  Fly   445 MVEVRSAQNTQDQP-IFVRIV-------------DKDSEWGWNNGLLTLISSMLQMNLNGYPFVL 495
               :|......::| :..|..             |..:||   :.|...|...|.:.|.|..|..
Human   609 ---LRQRSGGMERPFVLARAFFAGSQRFGAVWTGDNTAEW---DHLKISIPMCLSLGLVGLSFCG 667

  Fly   496 PDMIGGNGYYEKPPTKELFLRWLQANVFMPALQFSF-------VPWNFDDEAIAISKNFTALHAT 553
            .| :||   :.|.|..||.:||.|...:.|..:...       .||....:...|.::......:
Human   668 AD-VGG---FFKNPEPELLVRWYQMGAYQPFFRAHAHLDTGRREPWLLPSQHNDIIRDALGQRYS 728

  Fly   554 YTPYIMKLFKRAVDSGEPVNVPLWWIAPTDEVAQSIYDEFLLGEDIIAAPVVVEGATKRDIYLP- 617
            ..|:...|..:|...|.||..|||...|.|....:|.|::|||:.::..||...||....:|||
Human   729 LLPFWYTLLYQAHREGIPVMRPLWVQYPQDVTTFNIDDQYLLGDALLVHPVSDSGAHGVQVYLPG 793

  Fly   618 EGE-WQDGNSDQVYTGPTWVMDYAAPLDTLPYFLRVG 653
            :|| |.|..|.|.:.||. .:.....|.::|.|.|.|
Human   794 QGEVWYDIQSYQKHHGPQ-TLYLPVTLSSIPVFQRGG 829

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tobi	NP_651391.1	Glyco_hydro_31	246..653	CDD:279404	110/464 (24%)
tobi	NP_651391.1	GH31_NET37	255..621	CDD:269878	97/416 (23%)
GANAB	NP_938149.2	GH31_N	266..406	CDD:270212	36/172 (21%)
		GH31_GANC_GANAB_alpha	406..873	CDD:269889	112/469 (24%)
		DUF5110	849..918	CDD:319156
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1501
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810