DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tobi and Ganab

DIOPT Version :9

Sequence 1:	NP_651391.1	Gene:	tobi / 43072	FlyBaseID:	FBgn0261575	Length:	657	Species:	Drosophila melanogaster
Sequence 2:	NP_032086.1	Gene:	Ganab / 14376	MGIID:	1097667	Length:	966	Species:	Mus musculus

Alignment Length:	745	Identity:	174/745 - (23%)
Similarity:	255/745 - (34%)	Gaps:	204/745 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LSLLLASFCLWEAVHTCASIEQRYKFP--NSNVYVRLRRGD-----KLQYELMKGEKSLQTVTFD 63
            :||.|.|  :|:.:....| .|..|.|  .:........||     :.|.:..|.|......||.
Mouse   192 VSLALGS--VWDKIKNLFS-RQESKDPAEGNGAQPEATPGDGDKPEETQEKAEKDEPGAWEETFK 253

  Fly    64 NFDSSANLVETSSGSYQLTDGQSTVEFTLVKSGVVAGTGSEITHVKVSRDQVLQGTQPRDCVPLK 128
            ....|.....||.|          ::|:|.....|.|...   |....|.:|.:|.:|
Mouse   254 THSDSKPYGPTSVG----------LDFSLPGMEHVYGIPE---HADSLRLKVTEGGEP------- 298

  Fly   129 TGSTHWFSGPEQKQHYWPVERQRHSNYSYLPKELDN-------------------FGVGERYWLN 174
                                 .|..|......||:|                   .|:   :|||
Mouse   299 ---------------------YRLYNLDVFQYELNNPMALYGSVPVLLAHSFHRDLGI---FWLN 339

  Fly   175 GDGVFLYVESNT---PLF---ID--QNSAAYPDQLCLSAISALPYDPRVTSAKFVYHVAVAKDAK 231
            ....::.:.|||   .||   :|  |.|...|..           |.|..|...:..|.:.....
Mouse   340 AAETWVDISSNTAGKTLFGKMLDYLQGSGETPQT-----------DIRWMSESGIIDVFLMLGPS 393

  Fly   232 ---AAHRYAVKTFLGQPT-------GYPDERMVMHPVWSTWALYKAEVSDDVVRDFAKQILDNGF 286
               ...:||..|  |...       ||...|      |:    |:.|.  ||:.      :|.||
Mouse   394 VFDVFRQYASLT--GTQALPPLFSLGYHQSR------WN----YRDEA--DVLE------VDQGF 438

  Fly   287 NNSQLEIDDDWEDCYGA-----MTFRKNKFPDSKTLTDDLKALGFRVTLWIHPFIN-NNCTAIYD 345
            ::..:..|..|.|...|     .|:...:||....:.:.|.:...::...:.|.|. ::...:::
Mouse   439 DDHNMPCDVIWLDIEHADGKRYFTWDPTRFPQPLNMLEHLASKRRKLVAIVDPHIKVDSGYRVHE 503

  Fly   346 EAKSKGYLVLDHEGSSDTQW-WNSKPKDAAILDFTKTEVQEWFSKRLKRLQDEDGIDSFKFDAGE 409
            |.::.|..|...:||....| |   |..|:..|||...::.|:|            :.|.||..|
Mouse   504 ELRNHGLYVKTRDGSDYEGWCW---PGSASYPDFTNPRMRAWWS------------NMFSFDNYE 553

  Fly   410 TS------WLPSDPVLQASSSMVTPLQ-AV--------------GDYVRTVAAFG---------- 443
            .|      |...:.....:...||.|: ||              |.||....|.|
Mouse   554 GSAPNLYVWNDMNEPSVFNGPEVTMLKDAVHYGGWEHRDIHNIYGLYVHMATADGLIQRSGGIER 618

  Fly   444 DMVEVRSAQNTQDQPIFVRIVDKDSEWGWNNGLLTLISSMLQMNLNGYPFVLPDMIGGNGYYEKP 508
            ..|..|:..:...:...|...|..:||   :.|...|...|.:.|.|..|...| :||   :.|.
Mouse   619 PFVLSRAFFSGSQRFGAVWTGDNTAEW---DHLKISIPMCLSLALVGLSFCGAD-VGG---FFKN 676

  Fly   509 PTKELFLRWLQANVFMPALQFSF-------VPW----NFDDEAI--AISKNFTALHATYTPYIMK 560
            |..||.:||.|...:.|..:...       .||    .:.| ||  |:.:.::.|...||
Mouse   677 PEPELLVRWYQMGAYQPFFRAHAHLDTGRREPWLLASQYQD-AIRDALFQRYSLLPFWYT----- 735

  Fly   561 LFKRAVDSGEPVNVPLWWIAPTDEVAQSIYDEFLLGEDIIAAPVVVEGATKRDIYLP--EGEWQD 623
            ||.:|...|.||..|||...|.|....||.|:|:||:.::..||...||....:|||  |..|.|
Mouse   736 LFYQAHKEGFPVMRPLWVQYPEDMSTFSIEDQFMLGDALLIHPVSDAGAHGVQVYLPGQEEVWYD 800

  Fly   624 GNSDQVYTGPTWVMDYAAPLDTLPYFLRVG 653
            ..|.|.:.||. .:.....|.::|.|.|.|
Mouse   801 IQSYQKHHGPQ-TLYLPVTLSSIPVFQRGG 829

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tobi	NP_651391.1	Glyco_hydro_31	246..653	CDD:279404	118/466 (25%)
tobi	NP_651391.1	GH31_NET37	255..621	CDD:269878	105/418 (25%)
Ganab	NP_032086.1	GH31_N	264..406	CDD:270212	37/198 (19%)
		Glyco_hydro_31	387..832	CDD:279404	123/492 (25%)
		GH31_GANC_GANAB_alpha	406..873	CDD:269889	120/471 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1501
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810