DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tobi and myorg

DIOPT Version :9

Sequence 1:	NP_651391.1	Gene:	tobi / 43072	FlyBaseID:	FBgn0261575	Length:	657	Species:	Drosophila melanogaster
Sequence 2:	XP_003200879.1	Gene:	myorg / 100537539	ZFINID:	ZDB-GENE-091113-62	Length:	685	Species:	Danio rerio

Alignment Length:	717	Identity:	220/717 - (30%)
Similarity:	331/717 - (46%)	Gaps:	149/717 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LLLASFCLWEAVHTCASIEQRYKFPNSNVYVRLRRGDKLQYELMKGEKSLQTVTFDNFDSSANLV 72
            |::|:...|     |..|            ..||:.|.|:.||:...|       |.|     |:
Zfish    39 LVIAAVTAW-----CYYI------------ASLRKADLLKTELLDLNK-------DGF-----LI 74

  Fly    73 ETSSGSYQLTDG--QSTVEF-TLVKSGVVAGTGSEITHVKVSRDQV------LQGTQPRDCV--- 125
            ...:|...|..|  ..|::. :..|.||:         ::.||...      :...:|::.|
Zfish    75 RNQAGGIVLKMGFRSGTLDLDSCSKEGVI---------LRCSRSYAGKVNFFIMTVKPKETVMCY 130

  Fly   126 ---------------PLKTGSTHWFSGPEQKQHYWP----------------VERQRHSNYSYLP 159
                           .:....:||:.|.|....:||                |...||
Zfish   131 RVRWEELESDRPVEHAMSYNESHWYGGAETAVQHWPIAISGQQAPKPFVTSDVYSNRH------- 188

  Fly   160 KELDNFGVGERYWLNGDGVFLYVESNTPLFIDQN--------SAAYPDQLCLSAISALPYDP--- 213
               |..|:.||||::.:...:.:..:.|..:..|        .|.|.|.         ||.|
Zfish   189 ---DFGGILERYWISSNATAIKINDSVPFHLGWNDTEKTMYFQARYQDS---------PYKPASG 241

  Fly   214 RVTSAKFVYHVAVAKDAKAAHRYAVKTFLGQPTGYPDERMVMHPVWSTWALYKAEVSDDVVRDFA 278
            |...|:..|.|.|..|..:.|:..|:.:..:|...|.:.|..||:||||||:|..::.:.:..:|
Zfish   242 RPPYAELSYRVCVGSDVTSIHKVMVRRYFTKPNKVPAKEMFRHPIWSTWALHKTNINQEQLLTYA 306

  Fly   279 KQILDNGFNNSQLEIDDDWEDCYGAMTFRKNKFPDSKTLTDDLKALGFRVTLWIHPFINNNCTAI 343
            :.|..:|||.|.||:||.:...||.......|||::..:...|||.|..|:||.|||:|
Zfish   307 ENIRKHGFNCSHLELDDRYTSQYGDFDLDTRKFPNASAMFQKLKADGILVSLWTHPFVN------ 365

  Fly   344 YDEAK-----SKGYLVLDHEGS--SDTQWWNSKPKDAAILDFTKTEVQEWFSKRLKRLQDEDGID 401
            ||.|.     .||..|::..|.  :..:|||.   ...|:|||..|.:.||..:|:.|::..|:.
Zfish   366 YDSANFGHCVQKGLFVMEPTGQLPALVKWWNG---IGGIVDFTNPEARTWFLLQLRTLRNRYGVS 427

  Fly   402 SFKFDAGETSWLPSDPVLQASSSMVTPLQAVGDYVRTVAAFGDMVEVRSAQNTQDQPIFVRIVDK 466
            |||||||||::||..  .:....:..|......|......|.:..|:||...:|:...|.|:.|:
Zfish   428 SFKFDAGETNYLPWQ--FRTKVHLPDPSTFTRRYTEMAIPFNERAELRSGYGSQNISCFFRLNDR 490

  Fly   467 DSEWGWNNGLLTLISSMLQMNLNGYPFVLPDMIGGNGYYEKP------PTKELFLRWLQANVFMP 525
            ||.||...||.:||.::|.:::.||.|:||||||||.|..:.      |.:||::|||:...|||
Zfish   491 DSVWGHELGLKSLIPTVLTISILGYQFILPDMIGGNAYPNRTDGNGRLPDRELYIRWLELAAFMP 555

  Fly   526 ALQFSFVPWNFDDEAIAISKNFTALHAT-YTPYIMKLFKRAVDSGEPVNVPLWWIAPTDEVAQSI 589
            ::|||..||.:|||.:||::.||.||.| ..|.:::|....:|:|:|:..||||||.:||.|..:
Zfish   556 SMQFSIPPWEYDDEVVAIAQRFTELHETLVAPRVIELAGEVLDTGDPIIRPLWWIATSDETAFRV 620

  Fly   590 YDEFLLGEDIIAAPVVVEGATKRDIYLPEGEWQDGNSDQVYTG-------PTWVMDYAAPLDTLP 647
            ..:||:|:|::.|||:..|..:||||||.|.|:.      |.|       |..:.||...||.:.
Zfish   621 DSQFLIGDDLMVAPVLEPGKQERDIYLPAGRWKS------YKGERFDNKEPQLITDYPVDLDEIA 679

  Fly   648 YF 649
            ||
Zfish   680 YF 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tobi	NP_651391.1	Glyco_hydro_31	246..653	CDD:279404	162/425 (38%)
tobi	NP_651391.1	GH31_NET37	255..621	CDD:269878	150/379 (40%)
myorg	XP_003200879.1	GH31_NET37	283..652	CDD:269878	150/379 (40%)
myorg	XP_003200879.1	Glyco_hydro_31	298..678	CDD:279404	149/396 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582098
Domainoid	1	1.000	302	1.000	Domainoid score	I1372
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	350	1.000	Inparanoid score	I2252
OMA	1	1.010	-	-		QHG48838
OrthoDB	1	1.010	-	-		D238940at2759
OrthoFinder	1	1.000	-	-		FOG0004094
OrthoInspector	1	1.000	-	-		otm25530
orthoMCL	1	0.900	-	-		OOG6_103615
Panther	1	1.100	-	-	LDO	PTHR43053
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5348
SonicParanoid	1	1.000	-	-		X4465
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.940