DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tobi and gaa2

DIOPT Version :9

Sequence 1:	NP_651391.1	Gene:	tobi / 43072	FlyBaseID:	FBgn0261575	Length:	657	Species:	Drosophila melanogaster
Sequence 2:	XP_009304541.2	Gene:	gaa2 / 100332784	ZFINID:	ZDB-GENE-130530-749	Length:	966	Species:	Danio rerio

Alignment Length:	813	Identity:	170/813 - (20%)
Similarity:	269/813 - (33%)	Gaps:	266/813 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 TCASIEQRYKF---PNSNV-------------YVRLRRG---------------DKLQYELMKGE 54
            :|:.:.:.::|   |..||             :::..||               |...||||
Zfish   110 SCSQVPEGWRFDCYPERNVVVTEDMCHARNCCFIQSSRGNVSAQNGVPWCFYTPDYPSYELM--- 171

  Fly    55 KSLQTVTFDNFDSSANLVETSSGSY-QLTDGQSTV---EFTLVKSGVVAGTGSEITHVKVSRDQV 115
                           ::|:|..|.. :|...:.|.   :...::..|:......:      |.::
Zfish   172 ---------------SIVDTEMGKVGKLLRNKKTYYPKDIDALQLEVLFEEDHRL------RVKI 215

  Fly   116 LQGTQPRDCVPLKTGSTHWFSGPEQKQHYWPVERQRHSNYSYLPKEL-DNFG-VGERYWLNGDGV 178
            ...|:.|..||:..                ||..:|.||.||....: :.|| :.:|   ...|.
Zfish   216 TDPTEKRYEVPIDV----------------PVVHKRASNPSYTVDFIKEPFGLIVKR---TQTGA 261

  Fly   179 FLYVESNTPLFIDQNSAAYPDQLCLSAISALPYDPRVTSAKFVYHVAV----------------- 226
            .|...|..|||       |.||. |...|:||       .:|:|.:..
Zfish   262 VLLNTSIAPLF-------YADQF-LQMSSSLP-------TRFIYGLGEHRSNFLHDVQWNTLTMW 311

  Fly   227 AKDA---KAAHRYAVKTFL------GQPTGY---------------------------------- 248
            |:|.   :..:.|.|..|.      |...|:
Zfish   312 ARDVPPMELTNLYGVHPFYLSMESDGNAHGFFMLNSNAMDVVLQPAPAVTWRMIGGILDFYIFLG 376

  Fly   249 PDERMVM-----------HPVWSTWAL--------YKAEVSDDVVRDFAKQILDNGFNNSQLEID 294
            ||...|:           .|::  |||        ||   :.:......|::.:.|........|
Zfish   377 PDPSSVIGQYLDVVGKPAMPIY--WALGYHLCRWGYK---TSNKTWSVVKEMRNYGIPQDVQWND 436

  Fly   295 DDWEDCYGAMTFRKNKFPDSKTLTDDLKALGFRVTLWIHPFINNNCTA----IYDEAKSKGYLVL 355
            .|:.|.....|:..:.|.....|..||:.......:.:.|.|:|:...    .:||.|.||..:.
Zfish   437 IDYMDRSLDFTYDPSGFSTLPDLVKDLQRHDQHYVMILDPGISNSQPPGSYWPFDEGKKKGIFIN 501

  Fly   356 DHEGS--SDTQWWNSKPKDAAILDFTKTEVQEWFSKRLKRLQDEDGIDSFKFDAGETSWL----- 413
            |..|.  ....|    |...|..||:..:..||:.:.|:|..::...|....|..|.|..
Zfish   502 DSNGDILIGKVW----PGLTAFPDFSNPDTHEWWYQNLQRFHNKVPFDGVWIDMNEPSNFFDGSL 562

  Fly   414 -----------PSDP-----VLQASSSMVTPLQAVGDYVRTVAAFGDMVEVRSAQN-----TQDQ 457
                       |..|     .|:..:...:..|.:..:....:.:| ::|.::.::     |:.:
Zfish   563 NGCPDNELENPPYTPGILGGTLKGKTVCASARQKISVHYNIHSLYG-LMEAQATESALRRITKKR 626

  Fly   458 PIFVR--------------IVDKDSEWGWNNGLLTLISSMLQMNLNGYPFVLPDMIGGNGYYEKP 508
            |..:.              :.|..|:|   ..|.|.|..||..|:.|.|.:..|:.|..|    .
Zfish   627 PFIISRSTFPSQGKYSGHWLGDNRSQW---KDLATSIPGMLTFNILGIPLIGADICGFGG----S 684

  Fly   509 PTKELFLRWLQANVFMPALQFSFV------------PWNFDDEAIAISKNFTALHATYTPYIMKL 561
            .|:||.:||.|...|.|     |.            |..|...|....|....|..:..|::..|
Zfish   685 TTEELCVRWTQLGAFYP-----FTRNHNSIDEQDQEPTAFSPAARTAMKEAILLRYSLFPHLYTL 744

  Fly   562 FKRAVDSGEPVNVPLWWIAPTDEVAQSIYDEFLLGEDIIAAPVVVEGATKRDI---YLPEGEWQD 623
            |..|..||..|..||.:..||||....|..:||.|:.::..||:..|   ||.   |.|:|.|.|
Zfish   745 FHHAHVSGHTVATPLLFQFPTDEKTYGIDKQFLWGKSLLVTPVLDAG---RDYVVGYFPKGLWYD 806

  Fly   624 ---GNSDQVYTGPTWVMDYAAPLDTLPYFLRVG 653
               ||| .:.:|....::  ||.|.:...||.|
Zfish   807 FHTGNS-LISSGEEIKLE--APADKINLHLREG 836

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tobi	NP_651391.1	Glyco_hydro_31	246..653	CDD:279404	115/523 (22%)
tobi	NP_651391.1	GH31_NET37	255..621	CDD:269878	100/445 (22%)
gaa2	XP_009304541.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1501
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810