DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rha and Cep120

DIOPT Version :9

Sequence 1:	NP_651390.2	Gene:	rha / 43071	FlyBaseID:	FBgn0027376	Length:	1332	Species:	Drosophila melanogaster
Sequence 2:	NP_001178626.1	Gene:	Cep120 / 307302	RGDID:	1565619	Length:	989	Species:	Rattus norvegicus

Alignment Length:	1324	Identity:	256/1324 - (19%)
Similarity:	453/1324 - (34%)	Gaps:	407/1324 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 SDQVYCVLLHVVEAINFIGRDATDRQQIVMNAALNSVDFEVEGTQSEETIIFNSNCIWECDLAGI 94
            |||: .:::.::|..:|..|   .:..:|:.|..:......:.....:...|.:...||.|...:
  Rat     5 SDQL-LIVVSILEGRHFPKR---PKHMLVVEAKFDGEQLATDPVDHTDQPEFATELAWEIDRKVL 65

  Fly    95 KRLKTDHRPVKMTFYACRGGGAERKTIGTLLLPVRGLPVLGTVGSHNSPHLKMFWHKLICTSSEF 159
            .:.:....|:|:..:|.....:.::|:|.::|.:|     ....:..:|.    |::|:  |:::
  Rat    66 HQHRLQRTPIKLQCFALDPQTSAKETVGYIVLDLR-----TAQETKQAPK----WYQLL--SNKY 119

  Fly   160 RSHKPEVLLMLTIIKKSILHTKDFEHFMQFTEVKSPPTPPMQSPGHSITASMLQSQANVYVQSL- 223
            ...|.||.:.:|:         :.:...|....|:...||...   .:.||:|.......|..|
  Rat   120 TKFKSEVQISITL---------ETDTKAQVDSFKAKGAPPRDG---KVPASLLGVDPKDIVAVLN 172

  Fly   224 -----VQLGLLQVGNDPLVDCDIIEVVLQLKQLRNVTGLVKSLNQGKPPSSVILVFDFVGN-VTN 282
                 .|:|..:...|.......|....||:||...|   ..|.:.:|  .....:..:|| |||
  Rat   173 EEGGYHQIGPAECCTDSFTLSVTIAFATQLEQLIPCT---MKLPERQP--EFFFYYSLLGNDVTN 232

  Fly   283 IELKLNESDTYTLN---DVLGLRFKTSLRSMRLYFQRIFYLPINMYMNGTAIAHYRMDFTNLLPA 344
            ...    ||....|   :...:|.::|:..:|:|......|.|::.....::....:..:.||
  Rat   233 EPF----SDLINPNFEPERASVRIRSSVEVLRVYLALHSKLQIHLCCGDQSLGSTEIPLSGLL-- 291

  Fly   345 DDFFSDNRKYTSNGSFSFNRFGRTDSGREPKPPLMEYTFSVDLKTIFSRQEQEEPERTPSIASGN 409
                       ..||...|:          .|..:|..|::|           .|.|
  Rat   292 -----------KKGSTEINQ----------HPVTVEGAFTLD-----------PPNR-------- 316

  Fly   410 LDSEDEQYLGQTFCASVVRSRLNLNESEETDEIASNVMKQLANDSETEVIEMKSNTKNSKHNTSP 474
                             .:.:|.....|....:..:|..|........:||:|  |:|..   .|
  Rat   317 -----------------AKQKLAPVPVELAPTVGVSVALQREGIGSQSLIELK--TQNGH---EP 359

  Fly   475 QRKSQESKKLIRESS----RNTRNSLENLQNVDELTSLDLFELEEKRQEKIAELERIKAGQSE-- 533
            :...:.....|:|.:    ::.|.|....||....|..|..|.|.:..:...|.:::..|...
  Rat   360 EHSQKRVLTPIKEKTLTGPKSPRVSPAPPQNQTPPTKDDATESEVESLQYDKEPKQVVKGTGSIP 424

  Fly   534 -SLLQTELKVKKHKKADLELQGKKSQLETINE---VPPKS--------------LRKSKPVSQSE 580
             ||.|.            |..|..|::.|..:   ||..|              |..|.||:...
  Rat   425 ASLAQP------------EATGNPSEVVTSGQKIAVPATSHHFCFSIDLRSIHGLEISFPVNCIL 477

  Fly   581 LNNVPKIQENLPILNNQTKGSRIQKENCEENNEDLSYALSEEHSSSNEKLDKKPGASKTMRPPEH 645
            ..:.|......||:.|..          .|..:::...|.:.:.:.:         ..|| |.:.
  Rat   478 RYSYPFFGSAAPIMTNPP----------VEVRKNMEVFLPQSYCAFD---------FATM-PHQL 522

  Fly   646 VDTDLETDISVFSIQKKRKSKSKL--VISNELHNFEDSSTDTLEKGRPNPSKGDLKLRARWVE-V 707
            .||.|...:.|....|.:.||..|  :...:|.|...|     ||.|...:.|:...|..:.| |
  Rat   523 QDTFLRIPLLVELWHKDKMSKDLLLGIARIQLSNILSS-----EKTRFLGANGEQCWRQTYSEKV 582

  Fly   708 NKVQTQALIETEKFLQKTCPAE------LDEVLYED----QVALGQAKTSKPTKRKVKKPEEDKV 762
            ..:..|........|..|...|      :.|:...:    ..|:|| :.|.|.......|.|.:|
  Rat   583 PVIAAQGSNNRIVDLSYTMTLEDYGLVKMREIFVSESSQGMSAVGQ-RASPPPPPPAPCPSEIQV 646

  Fly   763 ---KRIDYETSYEEEITFCHPEKDPMTMIGENPINLNDLAS----SEEYISISEGNSKPAEIVYT 820
               :.::|:.:.|.|:.     |:....|.|:.:...:||.    :||:
  Rat   647 EPRETLEYKAALELEMW-----KEMQEDIFESQLKQKELAHMQALAEEW---------------- 690

  Fly   821 ETEQRVTFVNPKRDREKKKLSSLSKDDLLVEVRSEEYINLRSSARSKTDCVRKK-KKISIHEDQV 884
                      .|||||::.|                              |:|| .:.||.|.::
  Rat   691 ----------KKRDRERESL------------------------------VKKKVAEYSILEGKL 715

  Fly   885 YQAELTPSEEPSSQSESRGTDNANPITDQPQVDRVKKKKRDTSGDQQLFHVEYTSSQKSISKTEG 949
            .|| ||..|....|.          :|.:.::.|.:|       :.||      ..::::.:.:.
  Rat   716 QQA-LTELESREQQL----------VTAETELQRERK-------ELQL------ERERNLQELQD 756

  Fly   950 NVK-----CKELIEPDVEQTDVQVLKKKKLKKTLVTNDTVAQDYETLEEETIKPVKK-KIVRKKS 1008
            :|:     |       |.|.:::.||.|:|:          :|...|:::......| ||:.|.
  Rat   757 SVRRARDDC-------VHQVELERLKLKQLE----------EDKHRLQQQLNDAENKYKILEKD- 803

  Fly  1009 SVILEKIEDTENKGPADEVVSVEAKKIIKKKAKPACDNPTVEEYPKTKKGESRKLKSTSKEHFTM 1073
               .::.:|.:|..|...:.| |...:            |:|:....:|.||   .:.||.|:..
  Rat   804 ---FQQFKDQQNNKPEIRLQS-EINLL------------TLEKVELERKLES---ATKSKLHYKQ 849

  Fly  1074 EKPSSTIDSIGQKIKSWRRQQIDLFEQELARKEMHYIKQLEQMESQEARLHQLHKADTNLDETFI 1138
            :               |.|          |.||:..:||.|| |||.||   |.|....|::
  Rat   850 Q---------------WGR----------ALKELARLKQREQ-ESQMAR---LKKQQEELEQ--- 882

  Fly  1139 SKIPNVSEVDYEAKFTELEEHIALLKSEMEE--QVRLFENRSRELRQENLQLYSEKTELKVRIAA 1201
                      ...::...||. ..:|:|.:|  .:|...||.|:..|:..|.|.|       ||:
  Rat   883 ----------MRLRYLAAEEK-DTVKTEQQELLDIRNELNRLRQQEQKQYQDYKE-------IAS 929

  Fly  1202 LEQQIGDLKAQGSDEGDLKEVLGELRSQHYRYNNLAREKELFRKRWRRSAKRVHALKLAMYERSL 1266
            .:|  |..:..|.:|| |.:.|          ..|..|::..             ::..:|
  Rat   930 GKQ--GSPRGSGLEEG-LDDYL----------TRLIEERDTL-------------MRTGVY---- 964

  Fly  1267 EREHSNIRVEPID--LRKILTKDA 1288
              .|.:..:..:|  :|::|||::
  Rat   965 --NHEDRIISELDRQIREVLTKNS 986

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rha	NP_651390.2	DUF3668	158..386	CDD:289201	46/237 (19%)
Cep120	NP_001178626.1	C2	9..114	CDD:301316	18/116 (16%)
		DUF3668	118..340	CDD:289201	52/301 (17%)
		C2	<531..564	CDD:175973	10/37 (27%)
		CEP63	667..920	CDD:293650	83/412 (20%)
		Peptidase_C19	703..928	CDD:271592	73/335 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_2CMAG
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	82	1.000	Inparanoid score	I5109
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104962
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.850