DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG11902 and ZNF208

DIOPT Version :10

Sequence 1:NP_651389.3 Gene:CG11902 / 43070 FlyBaseID:FBgn0028647 Length:1426 Species:Drosophila melanogaster
Sequence 2:NP_009084.2 Gene:ZNF208 / 7757 HGNCID:12999 Length:1280 Species:Homo sapiens


Alignment Length:1500 Identity:334/1500 - (22%)
Similarity:507/1500 - (33%) Gaps:451/1500 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    23 CLDKDSSKSYYAVLQELTQ---------------IDLENTDD--NLPQH--------ICS----E 58
            |||......|..|:.|..:               |.||...:  |:.:|        |||    :
Human    20 CLDTAQQNLYRNVMLENYRNLVFLGIAAFKPDLIIFLEEGKESWNMKRHEMVEESPVICSHFAQD 84

  Fly    59 CW--------------RRMES----------AYTFVQQARKVHGELLAQLRECLDELPIDIPAEQ 99
            .|              ||.|.          .||.|.:. |||.|...:|.:.|......:  .|
Human    85 LWPEQGIEDSFQKVILRRYEKCGHENLHLKIGYTNVDEC-KVHKEGYNKLNQSLTTTQSKV--FQ 146

  Fly   100 NIKTEVDLDDGGNKSEVEVDDTEATALELKWQPASGSDREFCSGPESDEDQVEKKSYHLRRSSRK 164
            ..|.........|.:..::..|....|:.|...     |.||        .:...|.|.|..:|:
Human   147 RGKYANVFHKCSNSNRHKIRHTGKKHLQCKEYV-----RSFC--------MLSHLSQHKRIYTRE 198

  Fly   165 VKHPVESENEECKPSEPSPVKRRRGRPPGPAKSQAMTTDGRHACEVCGKTFSWYRDMQRHARIHF 229
            ..:..|...:....|......:           .|.|.:..:.|:.|||.||.:..:.:|..||.
Human   199 NSYKCEEGGKAFNWSSTLTYYK-----------SAHTGEKPYRCKECGKAFSKFSILTKHKVIHT 252

  Fly   230 ENASYVCDTCGKGF-----LRKDKYIFHL-----RCHK--KREAKWKALQLGKEWRFAERLYSSG 282
            ...||.|:.|||.|     |.|.| |.|.     :|.:  |..:|...|...|.....|:.|   
Human   253 GEKSYKCEECGKAFNQSAILTKHK-IIHTGEKPNKCEECGKAFSKVSTLTTHKAIHAGEKPY--- 313

  Fly   283 KLKRIECKLCGLSCQRMEELRAHLWDHADTETLVNLRTDSDVVREHFPGLPCDLDNIKKQICVDI 347
                 :||.||.:..::..|..|...||..                           |...|.:.
Human   314 -----KCKECGKAFSKVSTLITHKAIHAGE---------------------------KPYKCKEC 346

  Fly   348 ADGHLEKYACVVNFHGYELGLSDSDEECDSKESKYHCFVCNMSFNRKHRLMKHTLEDHSQSATTL 412
            ... ..|::.:........|           |..|.|..|..::.     ...||..|.:..|..
Human   347 GKA-FSKFSILTKHKVIHTG-----------EKPYKCEECGKAYK-----WPSTLSYHKKIHTGE 394

  Fly   413 PWQRCSSCKVGFLCLTMYNKHLNTHCQSKIRRYRCRKCSGRFMWPENLQRHACSHREEKTIASQI 477
            ...:|..|..||...::..||...|...|  .|:|.:|...|.|..||..|...|..|    :..
Human   395 KPYKCEECGKGFSMFSILTKHEVIHTGEK--PYKCEECGKAFNWSSNLMEHKKIHTGE----TPY 453

  Fly   478 LCSLCDISLSSLSQLRLHLITHQHDLNGISPEYNSLFFRSFYPDGLNCSISDLAVRIAEDFEVQD 542
            .|..|....|..|.|..|.:.|    ||..|                             ::.::
Human   454 KCEECGKGFSMFSILTKHKVIH----NGEKP-----------------------------YKCEE 485

  Fly   543 FDRYYNASTESGQELDLFESETELSDEETSKTSHICLLCGETSNSLMNLMKHQICLHSDGVAELP 607
            .|:    :|.:|::                  .:.|..||:..|...|||:|: .:|:   .|.|
Human   486 CDK----ATHAGEK------------------PYKCEECGKAFNWSSNLMEHK-RIHT---GEKP 524

  Fly   608 CRCDYCGSGFVSKALLQQHR-RHRCEKKHSRFHCRICNIRFIWESNYEKHEKTHHNKTKDAEERP 671
            .:|:.||..|.:.::|.:|: .|..||.   :.|..|...:.|.|....|:|.|      ..|:|
Human   525 YKCEECGKSFSTFSILTKHKVIHTGEKP---YKCEECGKAYKWSSTLSYHKKIH------TVEKP 580

  Fly   672 TKLKCDQCEKVFIWHKDLNRHKRLHQPQSAAQFDCPHCHRRFHRKDGLKSHLKVHAGNSDYINNQ 736
              .||::|.|.|.....|.:|||:|..:.  .:.|..|.:.|.:...|.:|..:|||...|    
Human   581 --YKCEECGKAFNQSAILIKHKRIHTGEK--PYKCEECGKTFSKVSTLTTHKAIHAGEKPY---- 637

  Fly   737 PVVPDVNQEMILARLSRPHGCKLIQCMICLSRHSKISDLRSHLSSHQYELSFAEDRDIPSASKAF 801
                                    :|..|.....|:|.|.:|.:.|..|..:    ......|||
Human   638 ------------------------KCKECGKTFIKVSTLTTHKAIHAGEKPY----KCKECGKAF 674

  Fly   802 YPDLENTLEKDELAEMIMADVQREFDLDRFISITNEAGLELNLESSETDTESEQEDNHSSLN--- 863
                                       .:|..:|                      .|..::   
Human   675 ---------------------------SKFSILT----------------------KHKVIHTGE 690

  Fly   864 --YPCNLCTTVVKRKHQLYAHQLEEHK---WEEAVLVCSNCQTRFVNESLLDHHSRTLCHNPQKL 923
              |.|..|.....     ::..|.|||   ..|....|..|...|...|:|..|.  :.|..:|.
Human   691 KPYKCEECGKAFN-----WSSNLMEHKRIHTGEKPYKCEECGKSFSTFSVLTKHK--VIHTGEKP 748

  Fly   924 FQCRKCPLRFRWRENLKLHMEVFHMLDELSIQDDLPKVDGDLQCGKCNRSFRMQKDLTRHTLMHG 988
            ::|.:|...::|...|..|.::.             .|:...:|.:|.::|.....|.:|..:|.
Human   749 YKCEECGKAYKWSSTLSYHKKIH-------------TVEKPYKCEECGKAFNRSAILIKHKRIHT 800

  Fly   989 QESNIFRCRWCARRFYRRANLLQHIARHGISVSQLPYAEAILDSYVNPGGRKKVECRVCNVSFPT 1053
            .|.. ::|..|.:.|.:.:.|..|.|.|                    .|.|..:|:.|..:|..
Human   801 DEKP-YKCEECGKTFSKVSTLTTHKAIH--------------------AGEKPYKCKECGKAFSK 844

  Fly  1054 IAALR----LHLETMP-----AGSHHDYSSLQNYS----------ITNQMGFEMDLYDSETDDED 1099
            .:.|.    :|....|     .|..:.:.|..:|.          ...:.|....::...|..|.
Human   845 FSILTKHKVIHTGEKPYKCEECGKAYKWPSTLSYHKKIHTGEKPYKCEECGKGFSMFSILTKHEV 909

  Fly  1100 SRTHIKPPGAPSSYTCNMCQLRCLRKFELYQHQQAMHRMEKISDGCDSC--LFKSVCPEIISHHK 1162
            ..|..||      |.|..|. :......::...:..|..||... |::|  .:||  ...:|:||
Human   910 IHTGEKP------YKCEECG-KAFSWLSVFSKHKKTHAGEKFYK-CEACGKAYKS--SSTLSYHK 964

  Fly  1163 RTQCENR--------------------------EKQFKCTRCGYKFMWESNLLLHMDLQHVKTED 1201
            :...|.:                          ||.:||..||..|.|.|||:.|          
Human   965 KIHTEEKPYKYEECGKGFSTFSILTKHKVIHTGEKPYKCEECGKAFNWSSNLMEH---------- 1019

  Fly  1202 QELDESKEASGDEPKTEGQVFQCGLCTRKYNRKDRLTAHLKKFHGPDCKPSTAKTPNRPISPKEP 1266
                 .|..:|:.|      ::|..|.:.::....||.| |..|..:                  
Human  1020 -----KKIHTGETP------YKCEECDKAFSWPSSLTEH-KATHAGE------------------ 1054

  Fly  1267 KRFLCAFCGKAVSSSSNLIIHMRRHTGEKPFKCEYCTMAFPRSSDLQCHRRTHTGERPHVCTVCQ 1331
            |.:.|..||||.|..|.|..|...|.||:|:|||.|..||..||:|..|:|.||||:|:.|..|.
Human  1055 KPYKCEECGKAFSWPSRLTEHKATHAGEEPYKCEECGKAFNWSSNLMEHKRIHTGEKPYKCEECG 1119

  Fly  1332 KGFARSYKLQQHMRIHSGERPYKCTYCEKSFTQSNDLTLHIRRHTGERPYQCGVCGERFIQGTAL 1396
            |.|:....|.:|..||:||:||||..|.|::..|:.|:.|.:.||.|:||:|..||:.|:..:.|
Human  1120 KSFSTFSILTKHKVIHTGEKPYKCEECGKAYKWSSTLSYHKKIHTVEKPYKCEECGKGFVMFSIL 1184

  Fly  1397 KNHRM 1401
            ..|::
Human  1185 AKHKV 1189

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG11902NP_651389.3 zf-AD 6..83 CDD:462262 25/112 (22%)
C2H2 Zn finger 208..228 CDD:275370 7/19 (37%)
C2H2 Zn finger 236..256 CDD:275370 10/29 (34%)
C2H2 Zn finger 384..405 CDD:275368 4/20 (20%)
C2H2 Zn finger 417..437 CDD:275368 6/19 (32%)
C2H2 Zn finger 447..463 CDD:275368 6/15 (40%)
C2H2 Zn finger 578..599 CDD:275368 8/20 (40%)
C2H2 Zn finger 610..629 CDD:275368 6/19 (32%)
C2H2 Zn finger 640..660 CDD:275368 6/19 (32%)
SUF4-like 673..>726 CDD:411020 15/52 (29%)
C2H2 Zn finger 676..703 CDD:411020 9/26 (35%)
C2H2 Zn finger 676..696 CDD:275368 8/19 (42%)
C2H2 Zn finger 706..726 CDD:411020 5/19 (26%)
C2H2 Zn finger 706..726 CDD:275368 5/19 (26%)
C2H2 Zn finger 762..782 CDD:275368 6/19 (32%)
C2H2 Zn finger 866..887 CDD:275368 3/20 (15%)
C2H2 Zn finger 896..918 CDD:275368 6/21 (29%)
C2H2 Zn finger 926..947 CDD:275368 5/20 (25%)
C2H2 Zn finger 967..987 CDD:275368 5/19 (26%)
C2H2 Zn finger 996..1016 CDD:275368 6/19 (32%)
C2H2 Zn finger 1044..1063 CDD:275368 5/22 (23%)
C2H2 Zn finger 1224..1244 CDD:275368 6/19 (32%)
C2H2 Zn finger 1271..1291 CDD:275368 9/19 (47%)
zf-H2C2_2 1283..1306 CDD:463886 10/22 (45%)
C2H2 Zn finger 1299..1319 CDD:275368 10/19 (53%)
C2H2 Zn finger 1327..1347 CDD:275368 6/19 (32%)
zf-H2C2_2 1340..1364 CDD:463886 12/23 (52%)
SFP1 <1349..1405 CDD:227516 22/52 (42%)
C2H2 Zn finger 1355..1375 CDD:275368 6/19 (32%)
C2H2 Zn finger 1383..1401 CDD:275368 6/17 (35%)
ZNF208NP_009084.2 KRAB 4..64 CDD:214630 9/43 (21%)
C2H2 Zn finger 175..195 CDD:275368 7/32 (22%)
C2H2 Zn finger 203..223 CDD:275368 2/30 (7%)
COG5048 227..619 CDD:227381 120/522 (23%)
C2H2 Zn finger 231..251 CDD:275368 7/19 (37%)
C2H2 Zn finger 259..279 CDD:275368 9/20 (45%)
C2H2 Zn finger 287..307 CDD:275368 5/19 (26%)
C2H2 Zn finger 315..335 CDD:275368 6/19 (32%)
C2H2 Zn finger 343..363 CDD:275368 2/20 (10%)
C2H2 Zn finger 371..391 CDD:275368 5/24 (21%)
C2H2 Zn finger 399..419 CDD:275368 6/19 (32%)
C2H2 Zn finger 427..447 CDD:275368 7/19 (37%)
C2H2 Zn finger 455..475 CDD:275368 6/19 (32%)
C2H2 Zn finger 499..519 CDD:275368 8/20 (40%)
C2H2 Zn finger 527..547 CDD:275368 6/19 (32%)
C2H2 Zn finger 555..575 CDD:275368 6/19 (32%)
C2H2 Zn finger 583..603 CDD:275368 8/19 (42%)
C2H2 Zn finger 611..631 CDD:275368 5/19 (26%)
C2H2 Zn finger 639..659 CDD:275368 6/19 (32%)
C2H2 Zn finger 667..687 CDD:275368 6/68 (9%)
COG5048 691..1133 CDD:227381 125/532 (23%)
C2H2 Zn finger 695..715 CDD:275368 6/24 (25%)
C2H2 Zn finger 723..743 CDD:275368 6/21 (29%)
C2H2 Zn finger 751..771 CDD:275368 5/19 (26%)
C2H2 Zn finger 779..799 CDD:275368 5/19 (26%)
C2H2 Zn finger 807..827 CDD:275368 6/19 (32%)
C2H2 Zn finger 835..855 CDD:275368 4/19 (21%)
C2H2 Zn finger 863..883 CDD:275368 3/19 (16%)
C2H2 Zn finger 891..911 CDD:275368 3/19 (16%)
C2H2 Zn finger 919..939 CDD:275368 2/20 (10%)
C2H2 Zn finger 947..967 CDD:275368 7/21 (33%)
C2H2 Zn finger 976..995 CDD:275368 0/18 (0%)
C2H2 Zn finger 1003..1023 CDD:275368 10/34 (29%)
C2H2 Zn finger 1031..1051 CDD:275368 6/20 (30%)
C2H2 Zn finger 1059..1079 CDD:275368 9/19 (47%)
C2H2 Zn finger 1087..1107 CDD:275368 10/19 (53%)
C2H2 Zn finger 1115..1135 CDD:275368 6/19 (32%)
SFP1 <1137..1217 CDD:227516 22/52 (42%)
C2H2 Zn finger 1143..1163 CDD:275368 6/19 (32%)
C2H2 Zn finger 1171..1191 CDD:275368 6/18 (33%)
SFP1 <1193..1273 CDD:227516
C2H2 Zn finger 1199..1219 CDD:275368
C2H2 Zn finger 1227..1247 CDD:275368
C2H2 Zn finger 1255..1275 CDD:275368
Blue background indicates that the domain is not in the aligned region.

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