Protein Alignment CG11902 and ZIC3

DIOPT Version :10

• Sequence 1: NP_651389.3
• Gene: CG11902 / 43070
• FlyBaseID: FBgn0028647
• Length: 1426
• Species: Drosophila melanogaster
• Sequence 2: NP_003404.1
• Gene: ZIC3 / 7547
• HGNCID: 12874
• Length: 467
• Species: Homo sapiens
• Alignment Length: 181
• Identity: 58/181 - (32%)
• Similarity: 85/181 - (46%)
• Gaps: 36/181 - (19%)

  Fly  1209 EASGDEPKTEGQVFQCGLCTRKYNRKDRLTAHLKKFH--GPDCKPSTAKTPNRPISPKEPKRFLC 1271
            ||....||..        |.|.::....|..|:...|  ||                 |....:|
Human   258 EAQLSRPKKS--------CDRTFSTMHELVTHVTMEHVGGP-----------------EQNNHVC 297

  Fly  1272 AF--C---GKAVSSSSNLIIHMRRHTGEKPFKCEY--CTMAFPRSSDLQCHRRTHTGERPHVCTV 1329
            .:  |   ||:..:...|:.|:|.|||||||.|.:  |...|.||.:|:.|:||||||:|..|..
Human   298 YWEECPREGKSFKAKYKLVNHIRVHTGEKPFPCPFPGCGKIFARSENLKIHKRTHTGEKPFKCEF 362

  Fly  1330 --CQKGFARSYKLQQHMRIHSGERPYKCTYCEKSFTQSNDLTLHIRRHTGE 1378
              |.:.||.|...::||.:|:.::||.|..|:||:|..:.|..|::.|..:
Human   363 EGCDRRFANSSDRKKHMHVHTSDKPYICKVCDKSYTHPSSLRKHMKVHESQ 413

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11902	NP_651389.3	zf-AD	6..83	CDD:462262
		C2H2 Zn finger	208..228	CDD:275370
		C2H2 Zn finger	236..256	CDD:275370
		C2H2 Zn finger	384..405	CDD:275368
		C2H2 Zn finger	417..437	CDD:275368
		C2H2 Zn finger	447..463	CDD:275368
		C2H2 Zn finger	578..599	CDD:275368
		C2H2 Zn finger	610..629	CDD:275368
		C2H2 Zn finger	640..660	CDD:275368
		SUF4-like	673..>726	CDD:411020
		C2H2 Zn finger	676..703	CDD:411020
		C2H2 Zn finger	676..696	CDD:275368
		C2H2 Zn finger	706..726	CDD:411020
		C2H2 Zn finger	706..726	CDD:275368
		C2H2 Zn finger	762..782	CDD:275368
		C2H2 Zn finger	866..887	CDD:275368
		C2H2 Zn finger	896..918	CDD:275368
		C2H2 Zn finger	926..947	CDD:275368
		C2H2 Zn finger	967..987	CDD:275368
		C2H2 Zn finger	996..1016	CDD:275368
		C2H2 Zn finger	1044..1063	CDD:275368
		C2H2 Zn finger	1224..1244	CDD:275368	4/19 (21%)
		C2H2 Zn finger	1271..1291	CDD:275368	7/24 (29%)
		zf-H2C2_2	1283..1306	CDD:463886	12/24 (50%)
		C2H2 Zn finger	1299..1319	CDD:275368	8/21 (38%)
		C2H2 Zn finger	1327..1347	CDD:275368	7/21 (33%)
		zf-H2C2_2	1340..1364	CDD:463886	9/23 (39%)
		SFP1	<1349..1405	CDD:227516	10/30 (33%)
		C2H2 Zn finger	1355..1375	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1383..1401	CDD:275368
ZIC3	NP_003404.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	66..107
		zf_ZIC	245..290	CDD:436441	9/39 (23%)
		Nuclear localization signal	297..322		7/24 (29%)
		C2H2 Zn finger	302..322	CDD:275368	6/19 (32%)
		SFP1	<324..408	CDD:227516	36/83 (43%)
		C2H2 Zn finger	330..352	CDD:275368	8/21 (38%)
		Nuclear localization signal	330..352		8/21 (38%)
		C2H2 Zn finger	360..382	CDD:275368	7/21 (33%)
		C2H2 Zn finger	390..410	CDD:275368	7/19 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	404..467		2/10 (20%)