DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11902 and sens

DIOPT Version :9

Sequence 1:	NP_651389.3	Gene:	CG11902 / 43070	FlyBaseID:	FBgn0028647	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	NP_524818.1	Gene:	sens / 45328	FlyBaseID:	FBgn0002573	Length:	541	Species:	Drosophila melanogaster

Alignment Length:	620	Identity:	130/620 - (20%)
Similarity:	223/620 - (35%)	Gaps:	213/620 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   829 DRFISITNEAGLEL----NLESSETDTESEQEDNHSSLNYPCNLCTTVVKRKHQLYAHQLEEHKW 889
            ||..::|.|...||    |.|:|:.|.:.:.||      .|.||.|     |.::.:......::
  Fly   102 DRDFALTPEKEHELQMNNNNENSKQDYQEQDED------MPLNLST-----KERITSDDSNRDQY 155

  Fly   890 EEAVLVCSNCQTRFVNESLLDHHSRTLCHNPQKLFQCRKCPLRFRWRENLKLHMEVFHMLDELSI 954
            ..:    ||..:|..:.|                                  .:|..|.:..|::
  Fly   156 HSS----SNNSSRSSSSS----------------------------------EVEQLHPMTSLNV 182

  Fly   955 QDDLPKVDGDLQCGKCNRSFRMQKDLTRHTLMHGQESNIF-----RCRWCARRFYRRANLLQHIA 1014
            ..  |.:.          :..::...|........:.||.     .|...|||           .
  Fly   183 TP--PPLS----------AVNLKSSSTPQQQRQRSQGNIIWSPASMCERSARR-----------E 224

  Fly  1015 RHGISVSQLPYAEAILDSYVNPGGRK-KVECRVCNVSFPTIAALRLHLETMPAGSHHDYSSLQNY 1078
            ::|:.:.:....|   :..|:|..|| |.|.|..::                       ||||
  Fly   225 QYGLKMEEQGDEE---EHQVDPIVRKFKYERRTASI-----------------------SSLQ-- 261

  Fly  1079 SITNQMGFEMDLYDSETDDEDSRTHIKPPGAPSSYTCNMCQLRCLRKFELYQHQQAMHRMEKISD 1143
                                   :.|....||:|......:      ||:.|.|...||...::.
  Fly   262 -----------------------SPISSLSAPASNAVQDLE------FEVAQQQLYAHRSAFMAG 297

  Fly  1144 GCDSCLFKSVCPEIISHHKRTQCENREKQFKCTRCGYKFMWESNLLLHMDLQH-VKTEDQELDES 1207
            ...:.|      |:::.|.:.:.|..::|                    ..|| :|.|.|:.:.|
  Fly   298 LTGNNL------ELLTQHLKLKSEQPQQQ--------------------QQQHRIKDEQQQDNRS 336

  Fly  1208 KEA---------------SGDEPKTEGQVFQCGLCTRKYNRKDRLTAHLKKFHGPDCKPSTAKTP 1257
            ..|               ...:|:.:.|        ::.:.:.:...|..:...||   |||...
  Fly   337 AAALMNLVAAAEFGYMRNQHQQPQQQQQ--------QQLHHQQQPQQHQHQQQHPD---STATDV 390

  Fly  1258 NRPISPKEPKRFLCAFCGKAVSSSSNLIIHMRRHTGEKPFKCEYCTMAFPRSSDLQCHRRTHTGE 1322
            .|                ::.||||....:..:.:| :.|:|:.|..:|.|||.|..|...|:..
  Fly   391 AR----------------RSSSSSSYQGENEEKRSG-RNFQCKQCGKSFKRSSTLSTHLLIHSDT 438

  Fly  1323 RPHVCTVCQKGFARSYKLQQHMRIHSGERPYKCTYCEKSFTQSNDLTLHIRRHTGERPYQCGVCG 1387
            ||:.|..|.|.|.:...:::|..||:||:|:|||.|.|:|:||::|..|:|:|||.:|:.|.:|.
  Fly   439 RPYPCQYCGKRFHQKSDMKKHTYIHTGEKPHKCTVCLKAFSQSSNLITHMRKHTGYKPFGCHLCD 503

  Fly  1388 ERFIQGTALKNHRMQQSHYEEGQ--ESVEPTRRTV 1420
            :.|.:...|:.||  :|.:||..  |.::|.:..|
  Fly   504 QSFQRKVDLRRHR--ESRHEEAPPVEDLKPLKMEV 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11902	NP_651389.3	zf-AD	6..83	CDD:285071
		C2H2 Zn finger	208..228	CDD:275368
		C2H2 Zn finger	236..256	CDD:275368
		C2H2 Zn finger	384..405	CDD:275368
		C2H2 Zn finger	417..437	CDD:275368
		C2H2 Zn finger	447..463	CDD:275368
		C2H2 Zn finger	578..599	CDD:275368
		C2H2 Zn finger	610..629	CDD:275368
		C2H2 Zn finger	640..660	CDD:275368
		C2H2 Zn finger	676..696	CDD:275368
		C2H2 Zn finger	706..726	CDD:275368
		C2H2 Zn finger	762..782	CDD:275368
		C2H2 Zn finger	866..887	CDD:275368	4/20 (20%)
		C2H2 Zn finger	896..918	CDD:275368	4/21 (19%)
		C2H2 Zn finger	926..947	CDD:275368	1/20 (5%)
		C2H2 Zn finger	967..987	CDD:275368	1/19 (5%)
		C2H2 Zn finger	996..1016	CDD:275368	4/19 (21%)
		C2H2 Zn finger	1044..1063	CDD:275368	1/18 (6%)
		C2H2 Zn finger	1224..1244	CDD:275368	1/19 (5%)
		C2H2 Zn finger	1271..1291	CDD:275368	4/19 (21%)
		zf-H2C2_2	1283..1306	CDD:290200	4/22 (18%)
		COG5048	1295..>1367	CDD:227381	30/71 (42%)
		C2H2 Zn finger	1299..1319	CDD:275368	8/19 (42%)
		zf-H2C2_2	1311..1336	CDD:290200	9/24 (38%)
		C2H2 Zn finger	1327..1347	CDD:275368	5/19 (26%)
		zf-H2C2_2	1340..1364	CDD:290200	12/23 (52%)
		C2H2 Zn finger	1355..1375	CDD:275368	10/19 (53%)
		zf-H2C2_2	1367..1392	CDD:290200	10/24 (42%)
		C2H2 Zn finger	1383..1401	CDD:275368	5/17 (29%)
sens	NP_524818.1	zf-C2H2	413..435	CDD:278523	9/21 (43%)
		C2H2 Zn finger	415..435	CDD:275368	8/19 (42%)
		COG5048	423..>497	CDD:227381	32/73 (44%)
		zf-H2C2_2	428..452	CDD:290200	9/23 (39%)
		C2H2 Zn finger	443..463	CDD:275368	5/19 (26%)
		zf-H2C2_2	455..480	CDD:290200	12/24 (50%)
		C2H2 Zn finger	471..491	CDD:275368	10/19 (53%)
		C2H2 Zn finger	499..516	CDD:275368	4/16 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24390
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010