DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11902 and CG17568

DIOPT Version :9

Sequence 1:	NP_651389.3	Gene:	CG11902 / 43070	FlyBaseID:	FBgn0028647	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	NP_609951.2	Gene:	CG17568 / 35198	FlyBaseID:	FBgn0032763	Length:	513	Species:	Drosophila melanogaster

Alignment Length:	608	Identity:	117/608 - (19%)
Similarity:	210/608 - (34%)	Gaps:	161/608 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   857 DNHSSLNYPCNLCT------------------------TVVKRKHQLYAHQLEEHKWEEAVLVCS 897
            |....||: |.||.                        .:..||:.....|||:   |.:.::|:
  Fly     3 DGSHWLNW-CRLCAKDDAHGNVKVQMNENSQGNWDNVLIMAIRKYFEVQMQLED---ELSSVLCT 63

  Fly   898 NCQTRFVNESLLDHHSRTLCHNPQKLFQCRKCPLRFRWRENLKLHMEVFHMLDELSIQDDLPKVD 962
            .|.| .::| |:|                        :.|::....::|.:|..       .:.|
  Fly    64 ECYT-LISE-LID------------------------FAEHVTKVQDIFEVLRR-------TETD 95

  Fly   963 GD--LQCGKCNRSFRMQKDLTRHTL-----MHGQESNIFRCRWCARRFYRRANLLQHIARHGISV 1020
            ||  :......:.|.:..|...|.:     :..:..|:::         :.|.||:.......|.
  Fly    96 GDQEMDVAALRQQFGLCDDDWTHIIKPIPALEMESDNVYQ---------KPAELLKDFPLAETSS 151

  Fly  1021 SQLPYAEAILDSYVNPGGRKKVECRVCNVSFPTIAALRLHLETMPAGSHHDYSSLQNYSITNQMG 1085
            .::..::....:::.. .:|.||..:....|..:..:.|...                  |:|:.
  Fly   152 QEMEISKRTTTTHLIQ-TKKNVEMEIPKQEFIDLGPILLEKN------------------TSQLD 197

  Fly  1086 FEMDLYDSETDDEDSRTHIKPPGAPSSYTCNMCQLRCLRKFELYQHQQAMHRMEKISDGC----- 1145
            .| |:.|....:|.|:..:....:|:|...::       |.|:.             |.|
  Fly   198 ME-DVLDELPQEELSQPRLDSTTSPASMENDV-------KSEML-------------DSCEGDDD 241

  Fly  1146 ----DSCLFKSVCPEIISHHKRTQCENREK--QFKCTRCGYKFMWESNLLLHMDLQHVKTEDQEL 1204
                |..|...|......:...:..|.:.|  :..|.:||..:...::...|::.:..:.|
  Fly   242 FLPVDGQLMDLVAVATTPNTLESTAEEKAKRGRMDCEKCGKVYRNRASYEKHLERECRRIE---- 302

  Fly  1205 DESKEASGDEPKTEGQVFQCGLCTRKYNRKDRLTAHLKKFHGPDCKPSTAKTPNRPISPKEPKRF 1269
               :....|:..|     .|.:|.:..:....|..|.:..|                  :..|.:
  Fly   303 ---RRVKVDKTTT-----TCDICNKTLSSATALKLHKEGIH------------------QNVKPY 341

  Fly  1270 LCAFCGKAVSSSSNLIIHMRRHTGEKPFKCEYCTMAFPRSSDLQCHRRTHTGERPHVCTVCQKGF 1334
            :|..|||.:.:.:.|..|...||..:||:|..|...|...:.|:.|.:.| .|...||.:|.|..
  Fly   342 ICDSCGKQLKTITALNEHKLVHTESRPFECTVCKAGFKNRARLKAHYQIH-AEPSFVCNICGKKL 405

  Fly  1335 ARSYKLQQHMRIHSGERPYKCTYCEKSFTQSNDLTLHIRRHTGERPYQCGVCGERFIQGTALKNH 1399
            ........|..:|:.||..||..|...|.:|..|..|:..|||.|||.|..||:.|......::|
  Fly   406 QTRRTWNMHKVVHTEERRLKCDVCGALFKRSKTLKTHLLSHTGLRPYVCNYCGKSFACNANCRSH 470

  Fly  1400 RMQQSHYEEGQESVE--PTRRTV 1420
            ::::...|..||...  |:|..|
  Fly   471 KLKKHPQEVQQEDGARLPSRLNV 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11902	NP_651389.3	zf-AD	6..83	CDD:285071
		C2H2 Zn finger	208..228	CDD:275368
		C2H2 Zn finger	236..256	CDD:275368
		C2H2 Zn finger	384..405	CDD:275368
		C2H2 Zn finger	417..437	CDD:275368
		C2H2 Zn finger	447..463	CDD:275368
		C2H2 Zn finger	578..599	CDD:275368
		C2H2 Zn finger	610..629	CDD:275368
		C2H2 Zn finger	640..660	CDD:275368
		C2H2 Zn finger	676..696	CDD:275368
		C2H2 Zn finger	706..726	CDD:275368
		C2H2 Zn finger	762..782	CDD:275368
		C2H2 Zn finger	866..887	CDD:275368	8/44 (18%)
		C2H2 Zn finger	896..918	CDD:275368	6/21 (29%)
		C2H2 Zn finger	926..947	CDD:275368	1/20 (5%)
		C2H2 Zn finger	967..987	CDD:275368	3/24 (13%)
		C2H2 Zn finger	996..1016	CDD:275368	3/19 (16%)
		C2H2 Zn finger	1044..1063	CDD:275368	2/18 (11%)
		C2H2 Zn finger	1224..1244	CDD:275368	4/19 (21%)
		C2H2 Zn finger	1271..1291	CDD:275368	6/19 (32%)
		zf-H2C2_2	1283..1306	CDD:290200	8/22 (36%)
		COG5048	1295..>1367	CDD:227381	22/71 (31%)
		C2H2 Zn finger	1299..1319	CDD:275368	5/19 (26%)
		zf-H2C2_2	1311..1336	CDD:290200	8/24 (33%)
		C2H2 Zn finger	1327..1347	CDD:275368	4/19 (21%)
		zf-H2C2_2	1340..1364	CDD:290200	8/23 (35%)
		C2H2 Zn finger	1355..1375	CDD:275368	6/19 (32%)
		zf-H2C2_2	1367..1392	CDD:290200	12/24 (50%)
		C2H2 Zn finger	1383..1401	CDD:275368	5/17 (29%)
CG17568	NP_609951.2	zf-AD	10..87	CDD:214871	16/106 (15%)
		COG5048	<313..471	CDD:227381	48/176 (27%)
		C2H2 Zn finger	314..335	CDD:275368	4/20 (20%)
		C2H2 Zn finger	343..363	CDD:275368	6/19 (32%)
		C2H2 Zn finger	371..391	CDD:275368	5/19 (26%)
		C2H2 Zn finger	398..418	CDD:275368	4/19 (21%)
		C2H2 Zn finger	426..446	CDD:275368	6/19 (32%)
		zf-H2C2_2	439..463	CDD:290200	12/23 (52%)
		C2H2 Zn finger	454..475	CDD:275368	5/20 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24390
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100