DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10669 and ZNF99

DIOPT Version :9

Sequence 1:	NP_001163728.1	Gene:	CG10669 / 43069	FlyBaseID:	FBgn0039329	Length:	933	Species:	Drosophila melanogaster
Sequence 2:	NP_001073878.2	Gene:	ZNF99 / 7652	HGNCID:	13175	Length:	864	Species:	Homo sapiens

Alignment Length:	807	Identity:	186/807 - (23%)
Similarity:	309/807 - (38%)	Gaps:	204/807 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   173 TKENV--CELCNKVFRYVTNLYRHKQRDHGILGKNGEDYEEDYYKCDLCDKTYKYVMALVKH--- 232
            ||:..  |..|:|.|..:::|.:|| |.|         ..|:.|||:...|.:|:...|:||
Human   168 TKKKTFKCMKCSKSFFMLSHLIQHK-RIH---------TRENIYKCEERGKAFKWFSTLIKHKII 222

  Fly   233 -------KHKEHG-----SSLLSN----NSGRKMPSTLAEDANPYSPASISETSTNQSRTNNDS- 280
                   |:|:.|     ||:.:.    ::|:| |....|....:               ||.|
Human   223 HTEDKPYKYKKCGKAFNISSMFTKCKIIHTGKK-PCKCEECGKVF---------------NNSST 271

  Fly   281 -LVHSIIKAVVLSDEDGHSGEDSYYNCDQCSKSYKYIVSLIKHKHKEHLDKESYKQSDDEDDRPL 344
             :.|.||          |:|:.. |.|::|.|::|....|.:|| ..|..::.||  .:|..:..
Human   272 LMKHKII----------HTGKKP-YKCEECGKAFKQSSHLTRHK-AIHTGEKPYK--CEECGKAF 322

  Fly   345 ASTSASASAPTAKPSRINRRVDGFDFHRSEPNGAKEIKCMICLRRFTKLRELRNH--LQNHPTDF 407
            ...||...                  |:....|.|..||..|.:.|::...||.|  :......:
Human   323 NHFSALRK------------------HQIIHTGKKPYKCEECGKAFSQSSTLRKHEIIHTEEKPY 369

  Fly   408 DFEAHGEPIERIAEGFFKTAVESTAEGLKRRIFRDLRMGVYGRYYSITNQARYEMTLDSSDTDSD 472
            .:|..|:....:: ...|..:..|.:       :..:....|:.:..:::......:.:::
Human   370 KYEECGKAFSNLS-ALRKHEIIHTGQ-------KPYKCEECGKAFKWSSKLTVHKVIHTAE---- 422

  Fly   473 GDGDDNVVIRRSYSCELCDSPEARWP--RKY-LLHQHHQKEHTWLDAPHVCQRCDSRFLNLQLLK 534
                      :...||.|.....|:.  ||: ::|...|        |:.|:.|...|.|...|:
Human   423 ----------KPCKCEECGKAFKRFSALRKHKIIHTGKQ--------PYKCEECSKAFSNFSALR 469

  Fly   535 HHTSQLCQNTLKRFMCDKCPQRFFWRRNLRAHLVEH----KCKQESYPCDQCSRSFQDKSAVTKH 595
            .|  ::.....|.:.|::|.:.|.|...|..|.|.|    .||     |::|.::|:..||:.||
Human   470 KH--EIIHTGEKPYKCEECGKAFKWSSKLTVHKVIHMEEKPCK-----CEECGKAFKHFSALRKH 527

  Fly   596 KLMMHRDSNMELLPCRWCTRTFYRPALLYKHLQRHGFTGQDLPLAETLLADASKPAGPKSVQCKI 660
            |::   .:..:...|..|.:.|...:.|.||...|                    .|.|..:|:.
Human   528 KII---HTGKKPYKCEECGKAFNNSSTLMKHKIIH--------------------TGKKPYKCEE 569

  Fly   661 CDIQFVSVADLRRHISMQGHSDQPSAYMISTATGFELLLDDTDDSDEETSGRTYSCDLCDLNFRR 725
            |...|...:.|.||.::                              .|..:.|.|:.|...|..
Human   570 CGKAFKQSSHLTRHKAI------------------------------HTGEKPYKCEECGKAFNH 604

  Fly   726 RREISEHQYSLHSFDKLPHNCEHCIFKTVDKNMLHQHLRTQCMNT-EKKFACMRCGYKFMWEENL 789
            ...:.:||. :|: .|.|:.||.|.......:.|.:|   :.::| ||.:.|..||..|.|..:|
Human   605 FSALRKHQI-IHT-GKKPYKCEECGKAFSQSSTLRKH---EIIHTGEKPYKCEECGKAFKWSSHL 664

  Fly   790 AQHLSTQHSKQPAVPEQ-------QPPLRRKR-----RFRYQCPHCWRSFVVQPSLDKHIRDMHV 842
            .:|......::|...|:       ...||:.:     :..|:|..|.::|....:|.|| ..:|.
Human   665 TRHKVIHTEEKPYKCEECGKAFNHFSALRKHKIIHTGKKPYKCEECGKAFSQSSTLRKH-EIIHT 728

  Fly   843 AKKNPGKKYLCSLCGLESLTPNKLNIHMRRHTGEKPFKCDLCDMRFTVHYELKVHRRKHTGERPY 907
            .:    |.|.|..||......:||.:|...||.|||.||:.|...|.....|:.|:..|||::||
Human   729 GE----KPYKCEECGKAFKWSSKLTVHKVIHTAEKPCKCEECGKAFKHFSALRKHKIIHTGKKPY 789

  Fly   908 QCTFCDKDFARPDKLRRHVFMH-NDKS 933
            :|..|.|.|.....||:|..:| .:||
Human   790 KCEECGKAFNNSSTLRKHEIIHTGEKS 816

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10669	NP_001163728.1	zf-AD	4..81	CDD:285071
		C2H2 Zn finger	178..199	CDD:275368	8/20 (40%)
		C2H2 Zn finger	216..233	CDD:275368	6/26 (23%)
		C2H2 Zn finger	520..542	CDD:275368	6/21 (29%)
		C2H2 Zn finger	550..570	CDD:275368	7/19 (37%)
		C2H2 Zn finger	579..600	CDD:275368	8/20 (40%)
		C2H2 Zn finger	610..630	CDD:275368	6/19 (32%)
		C2H2 Zn finger	716..737	CDD:275368	5/20 (25%)
		C2H2 Zn finger	746..766	CDD:275368	5/19 (26%)
		C2H2 Zn finger	776..795	CDD:275368	7/18 (39%)
		C2H2 Zn finger	820..838	CDD:275368	6/17 (35%)
		C2H2 Zn finger	853..873	CDD:275368	6/19 (32%)
		zf-H2C2_2	866..889	CDD:290200	10/22 (45%)
		COG5048	877..>930	CDD:227381	21/53 (40%)
		C2H2 Zn finger	881..901	CDD:275368	5/19 (26%)
		zf-H2C2_2	893..918	CDD:290200	11/24 (46%)
		C2H2 Zn finger	909..929	CDD:275368	7/19 (37%)
ZNF99	NP_001073878.2	KRAB	4..64	CDD:214630
		KRAB	4..43	CDD:279668
		C2H2 Zn finger	147..167	CDD:275368
		C2H2 Zn finger	175..195	CDD:275368	8/20 (40%)
		C2H2 Zn finger	203..223	CDD:275368	6/19 (32%)
		C2H2 Zn finger	232..251	CDD:275368	4/18 (22%)
		C2H2 Zn finger	259..279	CDD:275368	7/44 (16%)
		COG5048	267..684	CDD:227381	113/543 (21%)
		zf-H2C2_2	272..296	CDD:290200	9/34 (26%)
		C2H2 Zn finger	287..307	CDD:275368	7/20 (35%)
		zf-H2C2_2	299..324	CDD:290200	7/27 (26%)
		C2H2 Zn finger	315..335	CDD:275368	4/37 (11%)
		zf-H2C2_2	327..352	CDD:290200	8/42 (19%)
		C2H2 Zn finger	343..363	CDD:275368	6/19 (32%)
		C2H2 Zn finger	371..391	CDD:275368	3/20 (15%)
		zf-H2C2_2	383..407	CDD:290200	3/30 (10%)
		C2H2 Zn finger	399..419	CDD:275368	1/19 (5%)
		C2H2 Zn finger	427..447	CDD:275368	6/19 (32%)
		C2H2 Zn finger	455..475	CDD:275368	6/21 (29%)
		zf-H2C2_2	467..491	CDD:290200	5/25 (20%)
		C2H2 Zn finger	483..503	CDD:275368	7/19 (37%)
		C2H2 Zn finger	511..531	CDD:275368	8/22 (36%)
		zf-H2C2_2	523..548	CDD:290200	7/27 (26%)
		COG5048	534..857	CDD:227381	86/343 (25%)
		C2H2 Zn finger	539..559	CDD:275368	6/19 (32%)
		zf-H2C2_2	552..576	CDD:290200	9/43 (21%)
		C2H2 Zn finger	567..587	CDD:275368	6/49 (12%)
		zf-H2C2_2	579..604	CDD:290200	8/54 (15%)
		C2H2 Zn finger	595..615	CDD:275368	5/20 (25%)
		zf-H2C2_2	607..632	CDD:290200	8/26 (31%)
		C2H2 Zn finger	623..643	CDD:275368	5/22 (23%)
		zf-H2C2_2	636..659	CDD:290200	8/25 (32%)
		C2H2 Zn finger	651..671	CDD:275368	7/19 (37%)
		zf-H2C2_2	663..688	CDD:290200	4/24 (17%)
		C2H2 Zn finger	679..699	CDD:275368	3/19 (16%)
		zf-H2C2_2	691..716	CDD:290200	6/24 (25%)
		C2H2 Zn finger	707..727	CDD:275368	6/20 (30%)
		zf-H2C2_2	720..743	CDD:290200	9/27 (33%)
		C2H2 Zn finger	735..755	CDD:275368	6/19 (32%)
		C2H2 Zn finger	763..783	CDD:275368	5/19 (26%)
		zf-H2C2_2	775..800	CDD:290200	11/24 (46%)
		C2H2 Zn finger	791..811	CDD:275368	7/19 (37%)
		C2H2 Zn finger	819..839	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100