Protein Alignment CG10669 and Zfp974

DIOPT Version :10

• Sequence 1: NP_651388.1
• Gene: CG10669 / 43069
• FlyBaseID: FBgn0039329
• Length: 933
• Species: Drosophila melanogaster
• Sequence 2: NP_001360956.1
• Gene: Zfp974 / 73430
• MGIID: 1920680
• Length: 826
• Species: Mus musculus
• Alignment Length: 957
• Identity: 196/957 - (20%)
• Similarity: 339/957 - (35%)
• Gaps: 249/957 - (26%)

  Fly    28 TFVQLLVELTRIEVVMAQAEKFPQWLCYACAEKLESTY-DFVLQARRTHELWLQKIGDSLNGDD- 90
            ||..:.|:.::.|           |.|....:|:  .| |.:|:   |:...:..:|..::..|
Mouse    15 TFRDVAVDFSQEE-----------WACLDATQKV--LYRDMMLE---TYSNLVSVVGSCISKPDL 63

  Fly    91 ------EMEGTAAL--ECLRETPIHLFEIEGVTIKTEELASTQQAPKADPLVRPRIVKRSIVHFS 147
                  |.|...|:  |..|.:|....:.:..:|..|...|....||.......||:......||
Mouse    64 IVLLEQEKEPWMAVKEETDRPSPDLETDYDAGSISPENSISNGNFPKQSIKQLSRILDLEGSTFS 128

  Fly   148 DSDE-------------DLDDVPLRQRKIAASVC---GSDTTKENVCELCNKVFRYVTNLYRHKQ 196
            :...             |......::.::....|   ..:|.|...|:.|.|.|...:...:|:.
Mouse   129 NGHNHSIFSGLQGYKGGDAGQKVTKKEEMPPYTCQTLAHNTEKPYECKECGKCFGCRSTFTQHQS 193

  Fly   197 RDHGILGKNGEDYEEDYYKCDLCDKTYKYVMALVKHKHKEHGSSLLSNNSGRK---MPSTLAEDA 258
            ...|          |..|:|:.|.|.::....|.:|:....|......|...|   :|..|....
Mouse   194 IHTG----------EKPYECEECGKAFRLPQQLTRHQKFHSGEKPFECNECGKAFHLPDLLKYHK 248

  Fly   259 NPYS---PASISETSTNQSRTNNDSLVHSIIKAVVLSDEDGHSGEDSYYNCDQCSKSYKYIVSLI 320
            ..::   |....|....:       ::|:.:|.               |.|.:|.|::|...:|:
Mouse   249 TIHTGEKPFECRECGLYR-------IIHADVKP---------------YKCSECGKAFKRRSNLV 291

  Fly   321 KHKHKEHLDKESYKQSDDEDDRPLASTSASASAPTAKPSRINRRVDGFDFHRSEPNGAKEIKCMI 385
            :|: |.|.|:..::..|          ........|:.:|          |::...|.|..:|..
Mouse   292 QHQ-KTHSDERPFQCKD----------CGKGFIVLAQLTR----------HQNIHTGEKSFECHE 335

  Fly   386 CLRRFTKLRELRNHLQNHPTDFDFEAHGEPIERIAEGFFKTAVESTAEGLKRRIFRDLRMGVYGR 450
            |.:.|...::|..|.::|..:..|:.:                                  ..|:
Mouse   336 CGKAFRLPQQLTRHQKSHSGEKPFKCN----------------------------------ECGK 366

  Fly   451 YYSITNQARYEMTLDSS-------DTDSDGDGDDNVVIRR-------SYSCELCDSPEARWPRKY 501
            .:.:.:..:|..|:.:|       :.........|:|..|       .:.|..|.....|  .|.
Mouse   367 AFHLPDLLKYHKTIHTSTKPFECRECGKSFHRISNLVEHRLIHADVKPHKCNECGKAFKR--NKS 429

  Fly   502 LLHQHHQKEHTWLDAPHVCQRCDSRFLNLQLLKHHTSQLCQNTLKRFMCDKCPQRFFWRRNLRAH 566
            |:  .|||.|:. :.|..||.|...|:.|..|..|  |......|.|.|.:|.::|    ....|
Mouse   430 LM--QHQKIHSG-ERPFQCQECGKAFIVLAHLTRH--QTIHTGEKSFECKECGKKF----RTATH 485

  Fly   567 LVEHK---CKQESYPCDQCSRSFQDKSAVTKHKLMMHRDSNMEL--LPCRWCTRTFYRPALLYKH 626
            ||:|:   ..::.:.|:.|.::|:     .:..|..|:.::||.  ..|..|.:.|.....|.:|
Mouse   486 LVQHQSIHTGEKPFECNVCGKAFR-----LQIYLSEHQKTHMEAKHFECNICGKVFRLQVYLSEH 545

  Fly   627 LQRHGFTGQDLPLAETLLADASKPAGPKSVQCKICDIQFVSVADLRRHISMQGHSDQPSAYMIST 691
            .:.|                    ...|..:||:|...|.|...|.:|.::  |:|:
Mouse   546 QKTH--------------------TEEKPFKCKLCGSAFRSKYQLSKHHTV--HTDE-------- 580

  Fly   692 ATGFELLLDDTDDSDEETSGRTYSCDLCDLNFRRRREISEHQYSLHSFDKLPHNCEHC--IFKTV 754
                                :.|.|..|...||:|...::|| |:|: .|.|..|:.|  .::.
Mouse   581 --------------------KPYQCKECGKCFRQRSNFTDHQ-SIHT-GKKPFQCKECGKFYRL- 622

  Fly   755 DKNMLHQHLRTQCMNTEKKFACMRCGYKFMWEENLAQHLSTQHSKQPAVPEQQPPLRRKRRFRYQ 819
             ..:|.:|.::.  ::|:.:.|..||..|.....|..|.....|.:|                ::
Mouse   623 -NTLLIRHQKSH--SSERPYECKECGKAFHLPSELNNHQIVHTSNRP----------------FE 668

  Fly   820 CPHCWRSFVVQPSLDKHIRDMHVAKKNPGKKYLCSLCGLESLTPNKLNIHMRRHTGEKPFKCDLC 884
            |..|.:||..:.:|.:     |:|..:..|.|.|..||...:..:.|..|.:.|:.||||||..|
Mouse   669 CKVCGKSFKRESTLIQ-----HMAIHSGVKSYECKECGKGFIHRSSLLHHRKIHSDEKPFKCQEC 728

  Fly   885 DMRFTVHYELKVHRRKHTGERPYQCTFCDKDFARPDKLRRHVFMHND 931
            ...|.|...|..|:..||||:.::|..|...|....:|.:|..:|.|
Mouse   729 GKAFVVLAYLTRHQSIHTGEKSFECQHCGSAFRYKSQLSKHQRIHTD 775

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10669	NP_651388.1	zf-AD	4..80	CDD:462262	11/52 (21%)
		C2H2 Zn finger	178..199	CDD:275368	5/20 (25%)
		C2H2 Zn finger	216..233	CDD:275368	4/16 (25%)
		C2H2 Zn finger	520..542	CDD:275368	8/21 (38%)
		C2H2 Zn finger	550..570	CDD:275368	6/19 (32%)
		C2H2 Zn finger	579..600	CDD:275368	4/20 (20%)
		C2H2 Zn finger	610..630	CDD:275368	5/19 (26%)
		C2H2 Zn finger	716..737	CDD:275368	8/20 (40%)
		C2H2 Zn finger	746..766	CDD:275368	4/21 (19%)
		C2H2 Zn finger	776..795	CDD:275368	6/18 (33%)
		C2H2 Zn finger	820..838	CDD:275368	5/17 (29%)
		C2H2 Zn finger	853..873	CDD:275368	5/19 (26%)
		zf-H2C2_2	866..889	CDD:463886	10/22 (45%)
		C2H2 Zn finger	881..901	CDD:275368	6/19 (32%)
		zf-H2C2_2	893..918	CDD:463886	9/24 (38%)
		C2H2 Zn finger	909..929	CDD:275368	5/19 (26%)
Zfp974	NP_001360956.1	KRAB	14..75	CDD:214630	15/75 (20%)
		C2H2 Zn finger	175..195	CDD:275368	5/19 (26%)
		COG5048	199..574	CDD:227381	92/487 (19%)
		C2H2 Zn finger	203..223	CDD:275368	5/19 (26%)
		C2H2 Zn finger	231..251	CDD:275368	4/19 (21%)
		C2H2 Zn finger	277..297	CDD:275368	7/20 (35%)
		C2H2 Zn finger	305..325	CDD:275368	4/39 (10%)
		C2H2 Zn finger	333..353	CDD:275368	5/19 (26%)
		C2H2 Zn finger	361..381	CDD:275368	3/53 (6%)
		C2H2 Zn finger	389..409	CDD:275368	3/19 (16%)
		COG5048	411..781	CDD:227381	112/458 (24%)
		C2H2 Zn finger	417..437	CDD:275368	8/23 (35%)
		C2H2 Zn finger	445..465	CDD:275368	8/21 (38%)
		C2H2 Zn finger	473..493	CDD:275368	7/23 (30%)
		C2H2 Zn finger	501..521	CDD:275368	5/24 (21%)
		C2H2 Zn finger	529..549	CDD:275368	5/19 (26%)
		C2H2 Zn finger	557..577	CDD:275368	7/21 (33%)
		C2H2 Zn finger	585..605	CDD:275368	8/20 (40%)
		C2H2 Zn finger	613..633	CDD:275368	4/21 (19%)
		C2H2 Zn finger	641..661	CDD:275368	6/19 (32%)
		C2H2 Zn finger	669..689	CDD:275368	7/24 (29%)
		C2H2 Zn finger	697..717	CDD:275368	5/19 (26%)
		C2H2 Zn finger	725..745	CDD:275368	6/19 (32%)
		C2H2 Zn finger	753..773	CDD:275368	5/19 (26%)
		C2H2 Zn finger	781..801	CDD:275368