DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10669 and 2610008E11Rik

DIOPT Version :9

Sequence 1:	NP_001163728.1	Gene:	CG10669 / 43069	FlyBaseID:	FBgn0039329	Length:	933	Species:	Drosophila melanogaster
Sequence 2:	NP_001004362.2	Gene:	2610008E11Rik / 72128	MGIID:	1919378	Length:	669	Species:	Mus musculus

Alignment Length:	447	Identity:	111/447 - (24%)
Similarity:	181/447 - (40%)	Gaps:	82/447 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   483 RSYSCELCDSPEARWPRKYLLHQHHQKEHTWLDAPHVCQRCDSRFLNLQLLKHHTSQLCQNTLKR 547
            |.|.||.|   ...:.||..|.:|.::.|: .:.|:.|..|...|.....:..| .:...:..|.
Mouse   241 RRYECEEC---RKSFHRKANLIRHQRRTHS-REKPYECIECGKTFYCKSDVTRH-QRRTHSREKP 300

  Fly   548 FMCDKCPQRFFWRRNLRAHLVEHKCKQESYPCDQCSRSFQDKSAVTKHKLMMHRDSNMELLPCRW 612
            :.|.:|.:.|:.:..|..|......:::.|.|.:|:::|..||.:|:|:.....:...|   |..
Mouse   301 YECVECSKTFYCKSYLIRHQSRTHSREKPYECTECTKTFYCKSDLTRHQTTHSGEKPFE---CNE 362

  Fly   613 CTRTFYRPALLYKHLQRHGFTGQDLPLAETLLADASKPAGPKSVQCKICDIQFVSVADLRRHISM 677
            |::|||..:.|..|.:.|   ..|.|                 .:||.|...|.|.:.|.:|..:
Mouse   363 CSKTFYYKSDLANHQKTH---TDDNP-----------------YECKECRKTFCSKSSLNQHHRI 407

  Fly   678 QGHSDQPSAYMISTATGFELLLDDTDDSDEETSGRTYSCDLCDLNFRRRREISEHQYSLHSFDKL 742
                                          .|..:.|.|:.|..:|..:..::|||...|:.:|
Mouse   408 ------------------------------HTGEKPYECNECKKSFNSKSNLTEHQRRTHTREK- 441

  Fly   743 PHNCEHCIFKTVDKNMLHQHLRTQCMNTEKKFACMRCGYKFMWEENLAQHLSTQHSKQPAVPEQQ 807
            |:.|..|......::.|..|.||.  ..|:.:.|..|...|..:.||.||..|...::|
Mouse   442 PYECNECWKSFYCRSELTNHQRTH--TVERYYECKECRKNFYCKSNLNQHQRTHTGEKP------ 498

  Fly   808 PPLRRKRRFRYQCPHCWRSFVVQPSLDKHIRDMHVAKKNPGKKYLCSLCGLESLTPNKLNIHMRR 872
                      |:|..|.::|..:.:|::|.| .|..:    |.:.|..|.......:.|..|.:.
Mouse   499 ----------YECKDCNKAFYCKSNLNQHQR-THTGE----KPFACKDCSKAFYCKSSLVKHQKI 548

  Fly   873 HTGEKPFKCDLCDMRFTVHYELKVHRRKHTGERPYQCTFCDKDFARPDKLRRHVFMH 929
            |:||||::|:.|...|....:|..|:|.||||:||:|..|.|.|.....|.:|...|
Mouse   549 HSGEKPYECEECRKTFFQKSDLTRHQRTHTGEKPYECKDCSKTFYCKSNLNQHQRTH 605

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10669	NP_001163728.1	zf-AD	4..81	CDD:285071
		C2H2 Zn finger	178..199	CDD:275368
		C2H2 Zn finger	216..233	CDD:275368
		C2H2 Zn finger	520..542	CDD:275368	4/21 (19%)
		C2H2 Zn finger	550..570	CDD:275368	5/19 (26%)
		C2H2 Zn finger	579..600	CDD:275368	7/20 (35%)
		C2H2 Zn finger	610..630	CDD:275368	7/19 (37%)
		C2H2 Zn finger	716..737	CDD:275368	6/20 (30%)
		C2H2 Zn finger	746..766	CDD:275368	5/19 (26%)
		C2H2 Zn finger	776..795	CDD:275368	7/18 (39%)
		C2H2 Zn finger	820..838	CDD:275368	5/17 (29%)
		C2H2 Zn finger	853..873	CDD:275368	4/19 (21%)
		zf-H2C2_2	866..889	CDD:290200	9/22 (41%)
		COG5048	877..>930	CDD:227381	21/53 (40%)
		C2H2 Zn finger	881..901	CDD:275368	6/19 (32%)
		zf-H2C2_2	893..918	CDD:290200	13/24 (54%)
		C2H2 Zn finger	909..929	CDD:275368	6/19 (32%)
2610008E11Rik	NP_001004362.2	KRAB	10..69	CDD:214630
		KRAB	10..49	CDD:279668
		C2H2 Zn finger	218..237	CDD:275368
		C2H2 Zn finger	245..266	CDD:275368	7/23 (30%)
		C2H2 Zn finger	274..295	CDD:275368	4/21 (19%)
		COG5048	299..644	CDD:227381	96/384 (25%)
		C2H2 Zn finger	303..324	CDD:275368	5/20 (25%)
		C2H2 Zn finger	332..352	CDD:275368	7/19 (37%)
		C2H2 Zn finger	360..380	CDD:275368	7/19 (37%)
		C2H2 Zn finger	388..408	CDD:275368	7/49 (14%)
		zf-H2C2_2	400..425	CDD:290200	7/54 (13%)
		C2H2 Zn finger	416..437	CDD:275368	6/20 (30%)
		C2H2 Zn finger	445..465	CDD:275368	5/19 (26%)
		C2H2 Zn finger	473..493	CDD:275368	7/19 (37%)
		zf-H2C2_2	485..508	CDD:290200	9/38 (24%)
		C2H2 Zn finger	501..521	CDD:275368	6/20 (30%)
		zf-H2C2_2	513..536	CDD:290200	7/27 (26%)
		C2H2 Zn finger	529..549	CDD:275368	4/19 (21%)
		C2H2 Zn finger	557..577	CDD:275368	6/19 (32%)
		zf-H2C2_2	569..592	CDD:290200	12/22 (55%)
		C2H2 Zn finger	585..605	CDD:275368	6/19 (32%)
		C2H2 Zn finger	613..633	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S12346
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.950