DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10669 and Zfp715

DIOPT Version :9

Sequence 1:	NP_001163728.1	Gene:	CG10669 / 43069	FlyBaseID:	FBgn0039329	Length:	933	Species:	Drosophila melanogaster
Sequence 2:	NP_001344740.1	Gene:	Zfp715 / 69930	MGIID:	1917180	Length:	886	Species:	Mus musculus

Alignment Length:	1006	Identity:	203/1006 - (20%)
Similarity:	332/1006 - (33%)	Gaps:	305/1006 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 QAEKFPQWLCYACAEKLESTYDFVLQARRTHELWLQKIGDSLNGDDEMEGTAALECLRETPIHLF 109
            |.|...:|:.:.     :.|.:|      :.|.| |.:       |..:.....|.:.|...||.
Mouse    40 QPESCERWMSFE-----DVTVNF------SQEEW-QHL-------DSAQRCLYQEVMLEIYSHLL 85

  Fly   110 EI------EGVTIKTEELASTQQAPKADPLVRPRIVKRSIVHFSDSDEDLDDVPLRQRKIAASVC 168
            .:      .||..:.|:....|.|....|  ..|..::|      .::.|......:..:.::|.
Mouse    86 AVGYSIPSPGVIFRMEKGKEAQTAKAEFP--GQRCQEKS------GNDTLPQKASGKTSVYSNVA 142

  Fly   169 GSDTTKENVCELCNKVFRYVTNLYRHKQRDHGILGKNGEDYEEDYYKCDLCDKTYKYVMALVKHK 233
            ...|...:.|.|..:::: ..::.:..|::..:|...|...::...|    :..::|      .|
Mouse   143 SEVTRDGSWCSLLQELWQ-GADITKRGQQNQILLFPPGSFLKKTLSK----NSDHEY------QK 196

  Fly   234 HKEH---GSSLLSNNSGRKMPSTLAEDANPYSPASISETSTNQSRTNNDSLVHSIIKAVVLSDED 295
            .:|.   |..|:|...|.....:|        |.|:..:.........|.|:..:..:.:|....
Mouse   197 PRETIPLGPYLISTQEGLPQYHSL--------PKSLDVSLGANGHNERDQLIDIVASSQLLIPGS 253

  Fly   296 -------GHSGEDSY----------------------YNCDQCSKSYKYIVSLIKHKHKEHLDKE 331
                   .|.||:||                      ...||.|:..:.:.::..||.:..|..
Mouse   254 CNANCVVTHGGEESYRSTGNGDVLSHKQPLIYGNRFQVKADQSSQCQEVLYAISLHKPEITLTV- 317

  Fly   332 SYKQSDDEDDRPLAS---------TSASASAPTAKPSRINRRVDGFDFHRSEPNGAKEIKCMICL 387
                     |||:.|         .|.|.|.|      ...:||     |....|....||..|.
Mouse   318 ---------DRPIVSYNGGKAFLYVSDSLSHP------FQLKVD-----RVVHTGGDPYKCSSCE 362

  Fly   388 RRFTKLRELRNHLQNHPTDFDFEAHGEPIERIAEGFFKTAVESTAEGLKRRIFRDLRMGVYGRYY 452
            :.|.....|:.|.|.|
Mouse   363 KSFCNAAALQQHEQIH------------------------------------------------- 378

  Fly   453 SITNQARYEMTLDSSDTDSDGDG-DDNVVIRRSYSCELCDSPEARWPRKYLLHQHHQKEHTWLDA 516
              |.:..|..|| .....|||.. .::.:|.::::..:||.....:.||..|..|.|..:.  :.
Mouse   379 --TEEKLYVCTL-CGKAFSDGSAFYEHELIHKNHTPFICDICGKAFLRKSELTSHKQCHNG--EK 438

  Fly   517 PHVCQRCDSRF-LNLQLLKHHTSQLCQNTLKRFMCDKCPQRFFWRRNLRAHLVEHKCKQESYPCD 580
            |:.|..|:..| ...||..||.....:   |.:.|.:|.:.|.....|:.|...| ..::.|.|.
Mouse   439 PYKCNDCEKSFKFPSQLKVHHQIHTGE---KPYECRECGKSFSKTAKLKVHQRIH-TGEKPYVCS 499

  Fly   581 QCSRSFQDKSAVTKHKLMMHRDSNMELLPCRWCTRTFYRPALLYKHLQRHGFTGQDLPLAETLLA 645
            ||.::|..||.:.:|:.:...:...:   |..|.::|..|:.|..|...|
Mouse   500 QCGKAFNQKSILDRHEKLHPGEKPYK---CNDCGKSFNYPSQLKVHCHSH--------------- 546

  Fly   646 DASKPAGPKSVQCKICDIQFVSVADLRRHISMQGHSDQPSAYMISTATGFELLLDDTDDSDEETS 710
                 .|.|..:|..|...|....:|:.|  .|.|                            |.
Mouse   547 -----TGEKPYKCHECGKSFNFPCELKVH--YQNH----------------------------TG 576

  Fly   711 GRTYSCDLCDLNFRRRREISEHQYSLHSFDKLPHNCEHC--IFKTVDKNMLHQHLRTQCMNTEKK 773
            .:.|.|..|...|.:..::..| |.:|:.:: |:.|.||  .|.|.::...|:.:.|    .||.
Mouse   577 EKPYKCRECWKLFSKMSQLKAH-YRVHTGER-PYKCSHCGKAFSTKEQVQEHERIHT----GEKP 635

  Fly   774 FACMRCGYKFMWEENLAQHLSTQHSKQP--------------AVPEQQPPLRRK--------RRF 816
            |.|..||..|....:..:|......::|              .:|.||..:..|        :.|
Mouse   636 FVCTECGKAFSSRSSFRKHQLIHTKEKPFVSQKCETGLQEATLIPHQQLHIGEKPYKCPDCGKLF 700

  Fly   817 RY-----------------QCPHCWRSFVVQPSLDKHIR-------------------------- 838
            .|                 :||.|.:||.....|..|.|
Mouse   701 NYPSQLKSHYQIHTGEKPCKCPDCGKSFSKTSQLKAHSRIHTGERPYVCSVCGKAFKQLSTLSRH 765

  Fly   839 -DMHVAKKNPGKKYLCSLCGLESLTPNKLNIHMRRHTGEKPFKCDLCDMRFTVHYELKVHRRKHT 902
             .:|:.:    |.|.||.||....:|::|.:|:..||||:|:||..|...|....:|:.|.|.||
Mouse   766 EKIHMVE----KPYKCSFCGKSFCSPSELKVHLLIHTGERPYKCSSCWKAFCTKVQLQEHERIHT 826

  Fly   903 GERPYQCTFCDKDFARPDKLRRHVFMHNDKS 933
            |||||.||.|.|.|.......:|..:|..::
Mouse   827 GERPYVCTHCGKAFRSRSVFSKHKLIHRKET 857

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10669	NP_001163728.1	zf-AD	4..81	CDD:285071	7/35 (20%)
		C2H2 Zn finger	178..199	CDD:275368	3/20 (15%)
		C2H2 Zn finger	216..233	CDD:275368	1/16 (6%)
		C2H2 Zn finger	520..542	CDD:275368	7/22 (32%)
		C2H2 Zn finger	550..570	CDD:275368	5/19 (26%)
		C2H2 Zn finger	579..600	CDD:275368	7/20 (35%)
		C2H2 Zn finger	610..630	CDD:275368	6/19 (32%)
		C2H2 Zn finger	716..737	CDD:275368	5/20 (25%)
		C2H2 Zn finger	746..766	CDD:275368	6/21 (29%)
		C2H2 Zn finger	776..795	CDD:275368	5/18 (28%)
		C2H2 Zn finger	820..838	CDD:275368	7/17 (41%)
		C2H2 Zn finger	853..873	CDD:275368	7/19 (37%)
		zf-H2C2_2	866..889	CDD:290200	10/22 (45%)
		COG5048	877..>930	CDD:227381	21/52 (40%)
		C2H2 Zn finger	881..901	CDD:275368	6/19 (32%)
		zf-H2C2_2	893..918	CDD:290200	15/24 (63%)
		C2H2 Zn finger	909..929	CDD:275368	6/19 (32%)
Zfp715	NP_001344740.1	KRAB	48..105	CDD:214630	13/75 (17%)
		C2H2 Zn finger	327..350	CDD:275368	7/33 (21%)
		C2H2 Zn finger	358..378	CDD:275368	6/19 (32%)
		C2H2 Zn finger	386..406	CDD:275368	5/20 (25%)
		COG5048	410..849	CDD:227381	119/507 (23%)
		C2H2 Zn finger	414..434	CDD:275368	7/19 (37%)
		C2H2 Zn finger	442..462	CDD:275368	7/19 (37%)
		C2H2 Zn finger	470..490	CDD:275368	5/19 (26%)
		C2H2 Zn finger	498..518	CDD:275368	7/19 (37%)
		C2H2 Zn finger	526..546	CDD:275368	6/19 (32%)
		C2H2 Zn finger	554..574	CDD:275368	6/21 (29%)
		C2H2 Zn finger	582..602	CDD:275368	5/20 (25%)
		C2H2 Zn finger	610..630	CDD:275368	6/19 (32%)
		C2H2 Zn finger	638..658	CDD:275368	5/19 (26%)
		C2H2 Zn finger	693..713	CDD:275368	2/19 (11%)
		C2H2 Zn finger	721..741	CDD:275368	8/19 (42%)
		C2H2 Zn finger	749..769	CDD:275368	0/19 (0%)
		C2H2 Zn finger	777..797	CDD:275368	7/19 (37%)
		C2H2 Zn finger	805..825	CDD:275368	6/19 (32%)
		C2H2 Zn finger	833..853	CDD:275368	6/19 (32%)
		C2H2 Zn finger	861..881	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833397
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930