Protein Alignment CG10669 and 2610021A01Rik

DIOPT Version :10

• Sequence 1: NP_651388.1
• Gene: CG10669 / 43069
• FlyBaseID: FBgn0039329
• Length: 933
• Species: Drosophila melanogaster
• Sequence 2: NP_001423129.1
• Gene: 2610021A01Rik / 668572
• MGIID: 1922662
• Length: 834
• Species: Mus musculus
• Alignment Length: 1017
• Identity: 226/1017 - (22%)
• Similarity: 338/1017 - (33%)
• Gaps: 321/1017 - (31%)

  Fly    28 TFVQLLVELTRIEVVMAQAEKFPQWLCYACAEK-------LESTYDFVLQARRTHELWL-----Q 80
            ||..:.:|.::.|           |.|...|::       ||.....|.......:|.|     |
Mouse    19 TFKDVAIEFSQEE-----------WECLDSAQRTLYRDVMLEIYSILVSVGLSVSKLELLTCFEQ 72

  Fly    81 KIGDSLNGDDEMEG-TAALECLRETPIHLFEIEGVTIKTEELASTQQAPKADPLVRPRIVKRSIV 144
            ....|:.|..|::| ...|.|....  .||:||     :::.::.::.|  ......|:.|..:.
Mouse    73 NEEPSIAGIKELKGIEPVLSCFHNK--ELFKIE-----SKQESAQREGP--GQFGSSRLGKLHVN 128

  Fly   145 HFSDSDEDLDDVPLRQRKIAASVCGSDTTKENVCELCNKVFRYVTNLYRHKQRDHGILGKNGEDY 209
            ..:|:|.:::     |.|         |..||.....:..:..::. |||:             |
Mouse   129 LPNDTDCNVN-----QHK---------TVHENPVGSGSHHWLGISE-YRHR-------------Y 165

  Fly   210 EEDYYKCDLCDKTYKYVMALVKHKHKEHGSSLLS-NNSGRKMPSTLAEDANPYSPASISETSTNQ 273
            :||       :|......||    |..|.|.... ...|....:|..:|..| |...||..|. :
Mouse   166 QED-------NKGLTTDFAL----HNNHNSQFTEIAYQGNDSWNTYKQDVTP-SEGQISNCSL-E 217

  Fly   274 SRTNND------------SLV---HSIIKAVVLSDEDGHSGEDSYYNCDQCS------------- 310
            :..|||            ||.   :|..|....|.:|..:.|.|  ||.||:
Mouse   218 NCYNNDRCRGVSGQYTQSSLYQQDYSQEKLSTSSQQDKIANESS--NCSQCTEIKARGEFNRQRY 280

  Fly   311 --------------------------------KSYKYIVSLI------------KHK-------- 323
                                            ||:.:.:::.            |:|
Mouse   281 DKYSKVSVESPSIDRDKVNDIQRKPCLFMGSDKSFNFYLNMTQNDSSHTREKTQKYKVYKLEITS 345

  Fly   324 ------HKEHLDKESYKQSDDEDDRPLASTSASASAPTAKPSRINR------RVDGFDFHRSEPN 376
                  |.....::.|::|..........|......|...|.:...      :..|:..:.:...
Mouse   346 PSKLVGHPRFFVQQKYRKSGKYSRNSSGLTRLKMLQPGGTPCKSTECGKSFSQFSGYRENYTIHT 410

  Fly   377 GAKEIKCMICLRRFTKLRELRNHLQNHPTDFDFEAHGEPIERIAEGFFKTAVESTAEGLKRRIFR 441
            |.|..||.||.|.||....|:.|.:.|.        ||...|.     |...:|...|...:|..
Mouse   411 GEKPYKCKICKRSFTTGSYLQAHQRIHT--------GEKPYRC-----KECGKSFTHGYSLQIHL 462

  Fly   442 DLRMGVYGRYYSITNQARYEMTLDSSDTDSDGDGDDNVVIRRSYSCELCDSPEARWPRKYLLHQH 506
            .|..|                                   .:.|.|..|....|...   .|..|
Mouse   463 RLHTG-----------------------------------EKPYKCTDCGKAFAEGS---TLKSH 489

  Fly   507 HQKEHTWLDAPHVCQRCDSRFL---NLQLLKH---HTSQLCQNTLKRFMCDKCPQRFFWRRNLRA 565
            | :.||. :.|:.|:.|...|.   |||  .|   ||..      :.:.|..|.:.|..|..||.
Mouse   490 H-RIHTG-EKPYKCKECGKSFATRSNLQ--GHSRIHTGD------RPYKCADCGKSFTSRSCLRT 544

  Fly   566 HLVEHKCK--QESYPCDQCSRSFQDKSAVTKHKLMMHR-DSNMELLPCRWCTRTFYRPALLYKHL 627
            |   ||..  ::||.|.:|.|||.:.|.:..|    || .:..:...|:.|.::|.:.:.|..|.
Mouse   545 H---HKTHTGEKSYKCKECGRSFAEGSTLKSH----HRIHTGEKPYKCKECGKSFAKRSNLQVHS 602

  Fly   628 QRHGFTGQDLPLAETLLADASKPAGPKSVQCKICDIQFVSVADLRRHISMQGHSDQPSAYMISTA 692
            :.|                    .|.|..:|..|...|:|.:.||.|     |         .|.
Mouse   603 RIH--------------------TGDKPYKCADCGKAFISSSCLRTH-----H---------RTH 633

  Fly   693 TGFELLLDDTDDSDEETSGRTYSCDLCDLNFRRRREISEHQYSLHSFDKLPHNCEHCIFKTVDKN 757
            ||                .::|.|..|..:|.:...:..| |.:|:.:| |:.|..|.....:..
Mouse   634 TG----------------EKSYKCKECGKSFTQHSHLQTH-YRIHTGEK-PYICTDCGKSFSNSY 680

  Fly   758 MLHQHLRTQCMNTEKKFACMRCGYKFMWEENLAQHLSTQHSKQPAVPEQQPPLRRKRRFRYQCPH 822
            .|.:|.:|.  ..||.:.|..||..|....:|..|.......:|.                :|..
Mouse   681 SLQRHHKTH--TGEKSYKCKECGKSFSQGSHLQAHHRIHSRNKPC----------------KCKE 727

  Fly   823 CWRSFVVQPSLDKHIRDMHVAKKNPGKKYLCSLCGLESLTPNKLNIHMRRHTGEKPFKCDLCDMR 887
            |.:.|....:|..|.| :|..:    |.|.|..||......:.|..|.|.||||||:||..|...
Mouse   728 CGKGFAEGSTLKTHHR-IHTGE----KPYKCKECGKSFTEGSTLKAHHRIHTGEKPYKCKECGKS 787

  Fly   888 FTVHYELKVHRRKHTGERPYQCTFCDKDFARPDKLRRHVFMH 929
            ||:...||:|.|.||||:||:||.|.|.|.:...|:||..:|
Mouse   788 FTMASALKIHHRIHTGEKPYKCTDCGKSFTQHSHLQRHCRIH 829

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10669	NP_651388.1	zf-AD	4..80	CDD:462262	12/63 (19%)
		C2H2 Zn finger	178..199	CDD:275368	3/20 (15%)
		C2H2 Zn finger	216..233	CDD:275368	3/16 (19%)
		C2H2 Zn finger	520..542	CDD:275368	9/27 (33%)
		C2H2 Zn finger	550..570	CDD:275368	7/19 (37%)
		C2H2 Zn finger	579..600	CDD:275368	7/20 (35%)
		C2H2 Zn finger	610..630	CDD:275368	5/19 (26%)
		C2H2 Zn finger	716..737	CDD:275368	5/20 (25%)
		C2H2 Zn finger	746..766	CDD:275368	4/19 (21%)
		C2H2 Zn finger	776..795	CDD:275368	6/18 (33%)
		C2H2 Zn finger	820..838	CDD:275368	5/17 (29%)
		C2H2 Zn finger	853..873	CDD:275368	6/19 (32%)
		zf-H2C2_2	866..889	CDD:463886	12/22 (55%)
		C2H2 Zn finger	881..901	CDD:275368	8/19 (42%)
		zf-H2C2_2	893..918	CDD:463886	15/24 (63%)
		C2H2 Zn finger	909..929	CDD:275368	8/19 (42%)
2610021A01Rik	NP_001423129.1	KRAB	18..78	CDD:214630	13/69 (19%)
		C2H2 Zn finger	390..409	CDD:275368	1/18 (6%)
		COG5048	413..788	CDD:227381	125/517 (24%)
		C2H2 Zn finger	417..437	CDD:275368	8/19 (42%)
		C2H2 Zn finger	445..465	CDD:275368	4/24 (17%)
		C2H2 Zn finger	473..493	CDD:275368	6/23 (26%)
		C2H2 Zn finger	501..521	CDD:275368	7/21 (33%)
		C2H2 Zn finger	529..549	CDD:275368	9/22 (41%)
		C2H2 Zn finger	557..577	CDD:275368	9/23 (39%)
		C2H2 Zn finger	585..605	CDD:275368	5/19 (26%)
		C2H2 Zn finger	613..633	CDD:275368	8/33 (24%)
		C2H2 Zn finger	641..661	CDD:275368	5/20 (25%)
		C2H2 Zn finger	669..689	CDD:275368	4/19 (21%)
		C2H2 Zn finger	697..717	CDD:275368	6/19 (32%)
		C2H2 Zn finger	725..745	CDD:275368	6/20 (30%)
		C2H2 Zn finger	753..773	CDD:275368	6/19 (32%)
		C2H2 Zn finger	781..801	CDD:275368	8/19 (42%)
		zf-H2C2_2	793..818	CDD:463886	15/24 (63%)
		C2H2 Zn finger	809..829	CDD:275368	8/19 (42%)