DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10669 and Zfp808

DIOPT Version :9

Sequence 1:	NP_001163728.1	Gene:	CG10669 / 43069	FlyBaseID:	FBgn0039329	Length:	933	Species:	Drosophila melanogaster
Sequence 2:	NP_001034328.2	Gene:	Zfp808 / 630579	MGIID:	3704127	Length:	753	Species:	Mus musculus

Alignment Length:	793	Identity:	187/793 - (23%)
Similarity:	291/793 - (36%)	Gaps:	230/793 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 QRKIAASVCGSDTTKEN---------------VCELCNKVFRYVTNLYRHKQRDHGILGKNGEDY 209
            |:......||....|.:               :|..|::||.:..:|..|.:...|
Mouse   130 QKPYECKQCGKGFAKPSHLKRHERFHTVEQPFICNECDEVFSFKHHLQTHIRVHTG--------- 185

  Fly   210 EEDYYKCDLCDKTYKYVMALVKHKHKEHGSSLLSNNSGRKMPSTLAEDANPYS----PASISETS 270
             |..:||:||||::.      ||.|.:   |....::|.|          ||.    ..:.||..
Mouse   186 -EKPFKCNLCDKSFS------KHNHLQ---SHRRTHTGEK----------PYKCDQCDKAFSEKC 230

  Fly   271 TNQSRTNNDSLVHSIIKAVVLSDEDGHSGEDSYYNCDQCSKSYKYIVSLIKHKHKEHLDKESYKQ 335
            ..|:        |..|          |:||.. |.||||.|::.....|.|| .:.|..::.||
Mouse   231 NLQT--------HIRI----------HTGEKP-YKCDQCDKTFSEKCHLQKH-IRIHTGEKPYK- 274

  Fly   336 SDDEDDRPLASTSASASAPTAKPSRINRRVDGFDFHRSEPNGAKEIKCMICLRRFTKLRELRNHL 400
             .::.|:..:..|.                  ...||....|.|..||..|.:.|::...|:.|.
Mouse   275 -CNQCDKAFSQYST------------------LQTHRRTHTGEKPYKCNQCDKAFSQYGNLQTHR 320

  Fly   401 QNHPTDFDFEAHGEPIERIAEGFFKTAVESTAEGLKRRIFRDLRMGVYGRYYSITNQARYEMTLD 465
            :.|..:..|:.:     :..:.|.:                          ||         ||.
Mouse   321 RTHTGEKPFKCN-----QCDKAFSQ--------------------------YS---------TLQ 345

  Fly   466 SSDTDSDGDGDDNVVIRRSYSCELCDSPEARWPRKYLLHQHHQKEHTWLDAPHVCQRCDSRFL-N 529
            :......|:        :.|.|..||.   .:..|..| |.|.:.||. :.|:.|.:|:..|. |
Mouse   346 THRRTHTGE--------KPYKCNQCDK---AFSEKCSL-QRHIRIHTG-EKPYKCNQCNKAFSHN 397

  Fly   530 LQLLKH---HTSQLCQNTLKRFMCDKCPQRFFWRRNLRAHLVEHKCKQESYPCDQCSRSFQDKSA 591
            ..|..|   ||.:      |.:.|::|.:.|.....|:.|...| ..::.|.|:||.::|.:|..
Mouse   398 YHLHIHRRTHTGE------KPYKCNQCDKAFSIHFPLQNHKRTH-TGEKPYKCNQCDKAFSEKCH 455

  Fly   592 VTKHKLMMHRDSNMELLPCRWCTRTFYRPALLYKHLQRHGFTGQDLPLAETLLADASKPAGPKSV 656
            :..| :.:|  :..:...|..|.:.|.:...|..|.:.|                    .|.|..
Mouse   456 LQNH-IRIH--TGEKPYKCNQCDKAFSQYFSLQTHRRIH--------------------TGEKPF 497

  Fly   657 QCKICDIQFVSVADLRRHISMQGHSDQPSAYMISTATGFELLLDDTDDSDEETSGRTYSCDLCDL 721
            :|..||..|...:.|:.|  .:.|                            |..:.:.|:.||.
Mouse   498 KCNQCDKAFSQYSTLQTH--RRTH----------------------------TGEKPFKCNQCDK 532

  Fly   722 NFRRRREISEHQYSLHSFDKLPHNCEHCIFKTVDKNMLHQHLRTQCMNTEKKFACMRCGYKFMWE 786
            .|.:...:..|:.: ||.:| |..|..|.......|.|..|.||.  :.||.|.|.:|...|..:
Mouse   533 AFSKHSTLQSHRRT-HSGEK-PFKCSQCDKAFSQYNTLQAHRRTH--SGEKPFKCDQCDKAFSEK 593

  Fly   787 ENLAQHLSTQHSKQPAVPEQQPPLRRKRRFRYQCPHCWRSFVVQPSLDKHIRDMHVAKKNPGKKY 851
            .||.:|:.....::|                |:|..|.::|....:|..| |.:|..:    |.:
Mouse   594 CNLQKHIRIHTGEKP----------------YKCNQCDKAFSQYNTLQTH-RRIHTGE----KPF 637

  Fly   852 LCSLCGLESLTPNKLNIHMRRHTGEKPFKCDLCDMRFTVHYELKVHRRKHTGERPYQCTFCDKDF 916
            .|:.|.......:.|..|.|.|||||||||:.||..|:.:..|:.|||.||||:||:|..|||.|
Mouse   638 KCNQCDKAFSRHSTLQTHRRTHTGEKPFKCNQCDKVFSQYSNLQTHRRTHTGEKPYKCDQCDKAF 702

  Fly   917 ARPDKLRRHVFMH 929
            :....|:.||.:|
Mouse   703 SMKCNLQNHVRIH 715

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10669	NP_001163728.1	zf-AD	4..81	CDD:285071
		C2H2 Zn finger	178..199	CDD:275368	6/20 (30%)
		C2H2 Zn finger	216..233	CDD:275368	6/16 (38%)
		C2H2 Zn finger	520..542	CDD:275368	8/25 (32%)
		C2H2 Zn finger	550..570	CDD:275368	5/19 (26%)
		C2H2 Zn finger	579..600	CDD:275368	6/20 (30%)
		C2H2 Zn finger	610..630	CDD:275368	5/19 (26%)
		C2H2 Zn finger	716..737	CDD:275368	5/20 (25%)
		C2H2 Zn finger	746..766	CDD:275368	6/19 (32%)
		C2H2 Zn finger	776..795	CDD:275368	6/18 (33%)
		C2H2 Zn finger	820..838	CDD:275368	5/17 (29%)
		C2H2 Zn finger	853..873	CDD:275368	5/19 (26%)
		zf-H2C2_2	866..889	CDD:290200	14/22 (64%)
		COG5048	877..>930	CDD:227381	27/53 (51%)
		C2H2 Zn finger	881..901	CDD:275368	8/19 (42%)
		zf-H2C2_2	893..918	CDD:290200	15/24 (63%)
		C2H2 Zn finger	909..929	CDD:275368	8/19 (42%)
Zfp808	NP_001034328.2	KRAB	4..>45	CDD:214630
		KRAB	4..40	CDD:279668
		COG5048	<130..284	CDD:227381	47/204 (23%)
		C2H2 Zn finger	135..155	CDD:275368	3/19 (16%)
		C2H2 Zn finger	163..183	CDD:275368	6/19 (32%)
		zf-H2C2_2	175..199	CDD:290200	10/33 (30%)
		C2H2 Zn finger	191..211	CDD:275368	9/28 (32%)
		zf-H2C2_2	203..227	CDD:290200	6/36 (17%)
		C2H2 Zn finger	219..239	CDD:275368	5/37 (14%)
		zf-H2C2_2	231..255	CDD:290200	12/42 (29%)
		C2H2 Zn finger	247..267	CDD:275368	8/20 (40%)
		zf-H2C2_2	259..284	CDD:290200	7/27 (26%)
		C2H2 Zn finger	275..295	CDD:275368	4/37 (11%)
		zf-H2C2_2	288..312	CDD:290200	8/23 (35%)
		C2H2 Zn finger	303..323	CDD:275368	5/19 (26%)
		zf-H2C2_2	315..340	CDD:290200	5/29 (17%)
		COG5048	327..728	CDD:227381	128/527 (24%)
		C2H2 Zn finger	331..351	CDD:275368	5/59 (8%)
		zf-H2C2_2	344..367	CDD:290200	6/33 (18%)
		C2H2 Zn finger	359..379	CDD:275368	7/23 (30%)
		zf-H2C2_2	371..396	CDD:290200	9/26 (35%)
		C2H2 Zn finger	387..407	CDD:275368	6/19 (32%)
		C2H2 Zn finger	415..435	CDD:275368	5/19 (26%)
		zf-H2C2_2	428..451	CDD:290200	7/23 (30%)
		C2H2 Zn finger	443..463	CDD:275368	6/20 (30%)
		zf-H2C2_2	455..480	CDD:290200	5/27 (19%)
		C2H2 Zn finger	471..491	CDD:275368	5/19 (26%)
		zf-H2C2_2	483..508	CDD:290200	9/44 (20%)
		C2H2 Zn finger	499..519	CDD:275368	6/21 (29%)
		zf-H2C2_2	512..535	CDD:290200	7/52 (13%)
		C2H2 Zn finger	527..547	CDD:275368	5/20 (25%)
		zf-H2C2_2	540..564	CDD:290200	7/25 (28%)
		C2H2 Zn finger	555..575	CDD:275368	6/19 (32%)
		zf-H2C2_2	568..591	CDD:290200	9/24 (38%)
		C2H2 Zn finger	583..603	CDD:275368	6/19 (32%)
		zf-H2C2_2	595..620	CDD:290200	8/40 (20%)
		C2H2 Zn finger	611..631	CDD:275368	6/20 (30%)
		zf-H2C2_2	624..648	CDD:290200	7/28 (25%)
		C2H2 Zn finger	639..659	CDD:275368	5/19 (26%)
		zf-H2C2_2	652..676	CDD:290200	15/23 (65%)
		C2H2 Zn finger	667..687	CDD:275368	8/19 (42%)
		zf-H2C2_2	679..703	CDD:290200	14/23 (61%)
		C2H2 Zn finger	695..715	CDD:275368	8/19 (42%)
		zf-H2C2_2	707..730	CDD:290200	4/9 (44%)
		C2H2 Zn finger	723..743	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100