DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10669 and Zfp51

DIOPT Version :9

Sequence 1:	NP_001163728.1	Gene:	CG10669 / 43069	FlyBaseID:	FBgn0039329	Length:	933	Species:	Drosophila melanogaster
Sequence 2:	XP_006228071.2	Gene:	Zfp51 / 499056	RGDID:	1560046	Length:	779	Species:	Rattus norvegicus

Alignment Length:	995	Identity:	211/995 - (21%)
Similarity:	328/995 - (32%)	Gaps:	369/995 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTRTC------------RVCGCDDGRYWIETPVEKYAEKTFVQLLVELTRIEVVMAQ-------- 45
            :|:||            :....|.|:..|.:.:.|  :|...:...|:....|.|:|
  Rat    17 ITQTCPPVEQNKLPRRPKTVAKDQGQQVIYSLLLK--DKPKEEKQKEMAHSPVNMSQCLLTFGDV 79

  Fly    46 AEKFPQ--WLCYACAEKLESTYDFVLQARRTHELWLQK--IGDSLN-----GDDEMEGTAALECL 101
            |..|||  |.|...|::  :.|..|:....::.:.::.  |.|:::     ..|..:.....|.|
  Rat    80 AVDFPQEEWECLDSAQR--ALYIDVMLENYSNLVSVENYCICDTVHQHVKTKKDSCQCNELSEML 142

  Fly   102 RETPIHLFEIEGVTIKTEELASTQQAPKADPLVRPRIVKRSIVHFSDSDEDLDDVPLRQRKIAAS 166
            .::|.......|.|.:|..              ..|..|       |.|..:|.....|.|  ::
  Rat   143 HDSPHCALYKRGETAETSN--------------NYRCCK-------DRDASVDSSEPDQHK--ST 184

  Fly   167 VCGSDTTKENVCE----LCNKVFR----YVTNLYRHKQRDHGILGKNGEDY-------------- 209
            ..|.:..|...||    :|:.:.:    |..| .:|::.::       .||
  Rat   185 RTGEEPCKSEDCERSLNVCSSIIQDDRLYTAN-KKHREEEY-------NDYFNCTYNLMQQSLYL 241

  Fly   210 EEDYYKCDLCDKTYKYVMALVKHKHKEHGSSLLSNNSGRKMPSTLAEDANPYSPASISETSTNQS 274
            ||..:||..|.|.:.....|:||:.         .::|:|          ||. .:|.:.|.||.
  Rat   242 EEKPHKCGKCGKCFSTSSRLIKHQR---------IHTGKK----------PYK-CTICDKSYNQC 286

  Fly   275 RTNNDSLVHSIIKAVVLSDEDGHSGEDSYYNCDQCSKSYKYIVSLIKHKHKEHLDKESYKQSDDE 339
            .   :..:|..:          |:||.. |.|.:|.||::. .|::|...|.|..::.||..  :
  Rat   287 A---NLKIHQRL----------HTGEKP-YKCKECGKSFRQ-TSVLKSHQKMHTGEKPYKCK--Q 334

  Fly   340 DDRPLASTSASASAPTAKPSRINRRVDGFDFHRSEPNGAKEIKCMICLRRFTKLRELRNHLQNHP 404
            .|:..|.:|:         .|.::::     |.||    :...|..|.|.|.:|...|.|.:.|
  Rat   335 CDKSFAHSSS---------FRTHQKI-----HTSE----EHCSCPECGREFHQLSHFRKHYRLH- 380

  Fly   405 TDFDFEAHGEPIERIAEGFFKTAVESTAEGLKRRIFRDLRMGVYGRYYSITNQARYEMTLDSSDT 469
                                      |.|
  Rat   381 --------------------------TGE------------------------------------ 383

  Fly   470 DSDGDGDDNVVIRRSYSCELCDS-----PEARWPRKYLLHQHHQKEHTWLDAPHV---CQRCDSR 526
                         :.|.|..|..     ...||         |||.|    :|.:   |:.|...
  Rat   384 -------------KPYKCNECGRSFTHYASLRW---------HQKTH----SPEIYYECKECGKS 422

  Fly   527 FLNLQLLKH----HTSQLCQNTLKRFMCDKCPQRFFWRRNLRAHLVEHKCKQESYPCDQCSRSFQ 587
            |:.|..||.    ||.:      |.:.|:.|.:.|.....|:.|...| ..::.|.|.:|.:||.
  Rat   423 FIELSHLKRHYRIHTGE------KPYKCEVCDKSFTVNSTLKTHQKIH-TGEKPYKCRECDKSFT 480

  Fly   588 DKSAVTKHKLMMHRDSNMELLPCRWCTRTFYRPALLYKHLQRHGFTGQDLPLAETLLADASKPAG 652
            ..|                                   ||:||                .|...|
  Rat   481 HNS-----------------------------------HLRRH----------------QSVHTG 494

  Fly   653 PKSVQCKICDIQFVSVADLRRHISMQGHSDQPSAYMISTATGFELLLDDTDDSDEETSGRTYSCD 717
            .:..:||.||..|...:.|:.|..:                              .|..:||.|.
  Rat   495 ERPYKCKDCDKSFTECSTLKEHQKL------------------------------HTGEKTYKCG 529

  Fly   718 LCDLNFRRRREISEHQY-----SLHSFDKLPHNCEHC--IFKTVDKNMLHQHLRTQCMNTEKKFA 775
            .|..:|      |:|.|     .:|:.:: |:.|:.|  .|.|......||.:.|    .||.:.
  Rat   530 ECSKSF------SQHSYLRSHLRVHTGER-PYVCKECGKSFTTCSTLRTHQKIHT----GEKPYK 583

  Fly   776 CMRCGYKFMWEENLAQHLSTQHSKQPAVPEQQPPLRRKRRFRYQCPHCWRSFVVQPSLDKHIRDM 840
            |..|...|..:.:|..|......::|                |.|..|.|||.....|..| :.:
  Rat   584 CRECNKSFTQDSHLRTHHRVHTGERP----------------YSCKECDRSFTRCSYLRAH-QKI 631

  Fly   841 HVAKKNPGKKYLCSLCGLESLTPNKLNIHMRRHTGEKPFKCDLCDMRFTVHYELKVHRRKHTGER 905
            |..:    |.|.|..|.:..|..:.|.||...||||||:||..||:.|.....||.|::.||||:
  Rat   632 HTGE----KPYKCKDCDISFLRISSLRIHQEIHTGEKPYKCKDCDISFNQISNLKRHQKLHTGEK 692

  Fly   906 PYQCTFCDKDFARPDKLRRH 925
            ||:|..|||.|.:...||.|
  Rat   693 PYKCMECDKSFTQNSNLRAH 712

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10669	NP_001163728.1	zf-AD	4..81	CDD:285071	20/98 (20%)
		C2H2 Zn finger	178..199	CDD:275368	6/28 (21%)
		C2H2 Zn finger	216..233	CDD:275368	5/16 (31%)
		C2H2 Zn finger	520..542	CDD:275368	8/25 (32%)
		C2H2 Zn finger	550..570	CDD:275368	5/19 (26%)
		C2H2 Zn finger	579..600	CDD:275368	5/20 (25%)
		C2H2 Zn finger	610..630	CDD:275368	2/19 (11%)
		C2H2 Zn finger	716..737	CDD:275368	6/25 (24%)
		C2H2 Zn finger	746..766	CDD:275368	6/21 (29%)
		C2H2 Zn finger	776..795	CDD:275368	5/18 (28%)
		C2H2 Zn finger	820..838	CDD:275368	7/17 (41%)
		C2H2 Zn finger	853..873	CDD:275368	6/19 (32%)
		zf-H2C2_2	866..889	CDD:290200	13/22 (59%)
		COG5048	877..>930	CDD:227381	24/49 (49%)
		C2H2 Zn finger	881..901	CDD:275368	7/19 (37%)
		zf-H2C2_2	893..918	CDD:290200	14/24 (58%)
		C2H2 Zn finger	909..929	CDD:275368	8/17 (47%)
Zfp51	XP_006228071.2	KRAB	73..113	CDD:396083	9/41 (22%)
		COG5048	231..647	CDD:227381	132/679 (19%)
		C2H2 Zn finger	248..268	CDD:275368	6/28 (21%)
		C2H2 Zn finger	276..296	CDD:275368	5/32 (16%)
		C2H2 Zn finger	304..324	CDD:275368	7/20 (35%)
		C2H2 Zn finger	332..352	CDD:275368	4/35 (11%)
		C2H2 Zn finger	360..380	CDD:275368	7/19 (37%)
		C2H2 Zn finger	416..436	CDD:275368	6/19 (32%)
		C2H2 Zn finger	444..464	CDD:275368	5/19 (26%)
		C2H2 Zn finger	472..492	CDD:275368	10/70 (14%)
		C2H2 Zn finger	500..520	CDD:275368	7/49 (14%)
		C2H2 Zn finger	528..548	CDD:275368	6/25 (24%)
		C2H2 Zn finger	556..576	CDD:275368	6/19 (32%)
		C2H2 Zn finger	584..604	CDD:275368	5/19 (26%)
		C2H2 Zn finger	612..632	CDD:275368	7/20 (35%)
		C2H2 Zn finger	640..660	CDD:275368	6/19 (32%)
		C2H2 Zn finger	668..688	CDD:275368	7/19 (37%)
		zf-H2C2_2	680..705	CDD:404364	14/24 (58%)
		C2H2 Zn finger	696..715	CDD:275368	8/17 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336939
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.030