Protein Alignment CG10669 and Zfp457

DIOPT Version :10

• Sequence 1: NP_651388.1
• Gene: CG10669 / 43069
• FlyBaseID: FBgn0039329
• Length: 933
• Species: Drosophila melanogaster
• Sequence 2: NP_001003666.2
• Gene: Zfp457 / 431706
• MGIID: 2664334
• Length: 647
• Species: Mus musculus
• Alignment Length: 645
• Identity: 136/645 - (21%)
• Similarity: 233/645 - (36%)
• Gaps: 186/645 - (28%)

  Fly  1006 VDLPP---PPEEFDMPLDQRGGGGSGGSGGMLEKSIAPSNDVRNTEPSVEEASTRFGVSLRKREP 1067
            |..||   |......|:|....||.           .|..|:  |..::|||::  ||:     |
Mouse   173 VKTPPRRLPTVMVRSPIDSASPGGD-----------YPLGDL--TPTTMEEATS--GVT-----P 217

  Fly  1068 STDSCSSLGSPADAMINTVGDPSSLPIPPPPPAKDLKADPKRVTNVPKCLQGDVVGGKRTAGPLH 1132
            .|       .|:..:.:..|.|.:|    ||.:..|:|....||:  ...|..::|.|.|
Mouse   218 GT-------LPSTPVTSFPGIPDTL----PPGSAPLEAPMTPVTD--DSPQKKMLGQKAT----- 264

  Fly  1133 GTSDPASQLVSE-LAESMHLPKAPSPLTTAQEPQHHQQQQPISHYKSS----DVSSLRKPVSMSK 1192
               .|.|.|:|| |.:...||.:|..:..::.|      .|..|..|:    :|..:...:  ..
Mouse   265 ---PPPSPLLSELLKKGSLLPTSPRLVNESEMP------VPSGHLSSTGVLLEVGGVLPMI--HG 318

  Fly  1193 STILPSTNAAANDNYSAATNAASGVPQP--PFKA------QLKKVDTAKRAPAQPAKKE------ 1243
            ..|.|:|:|.|     |:..|:...|:|  |.:|      ....:|:::.:....:.||
Mouse   319 GDIQPATSAVA-----ASPAASVSQPEPCVPLEAVGDPQTVTVSMDSSEISMIINSIKEECFRSG 378

  Fly  1244 --ESTGG----IIDFKSRLRKVDQNNTEVSSNGGSGGGESVDPPT---------SNVDNNNKHQA 1293
              |:.||    .||.|..|...::.:..||..     ||.:|..|         ..||:
Mouse   379 VAEAPGGSKAPSIDGKEDLDLAEKMDIAVSYT-----GEELDFETVGDIIAIIEDKVDD------ 432

  Fly  1294 GGNSLQSIHNNNFNTTASSNNSNGNILNNNDNSASSSSSENENHRSAK-------KGETGTPMVV 1351
                    |....:..|.             .:|.|...||::.:|..       :.|...|:.:
Mouse   433 --------HPEVLDVAAV-------------EAALSFCEENDDPQSLPGPWEHPIQQERDKPVPL 476

  Fly  1352 RNGTSISGKNSMD---SSNKLLLENNELN----SLKLKKTN-----VASTIVTGTAPIDSNKVIE 1404
            ........:..:|   |..|.:.|..::.    .:|::.|.     ..:.||.|..|:.|.:..|
Mouse   477 PAPEMTVKQERLDFEESETKGIHELVDIRDSGVEIKVEPTEPEPGMSGAEIVAGVGPVPSLEPPE 541

  Fly  1405 LKKTEIKIELSDDRKRESLEGNSLKVDSGGGSGDNLSTGSSGAGGEDGDGKRKSTGSISSLKKLW 1469
            |:..::     |:..|.|..|...:.|           ||||.|.|......|:..|..|:....
Mouse   542 LRSQDL-----DEEPRSSAAGEMGEAD-----------GSSGKGEERPLPAVKTEASPESMLSPS 590

  Fly  1470 EAKESPSDPLSAQLSPKLGTKSVANMVPKMNNNVEAEDGSVGGGH--DATQQQQQQQ-------- 1524
            .......|||.|:...|.          :|:::::.|.|::.|..  ||..:::::.
Mouse   591 HGSNPIEDPLEAETQHKF----------EMSDSLKEESGTIFGSQIKDAPGEEEEEDGVSEAASL 645

  Fly  1525 EQLQQANAGPAGCVSTGTLGSNKKPAVPMKPSKFASIYATPVQNMMQTASSTVASATGSS 1584
            |:.::.:.| .|.:|.    .:.:|.|......| ||:...:|:  .|...::.|:..||
Mouse   646 EEPKEEDQG-EGYLSE----MDNEPPVSESDDGF-SIHNATLQS--HTLGDSIPSSPASS 697

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10669	NP_651388.1	zf-AD	4..80	CDD:462262
		C2H2 Zn finger	178..199	CDD:275368
		C2H2 Zn finger	216..233	CDD:275368
		C2H2 Zn finger	520..542	CDD:275368
		C2H2 Zn finger	550..570	CDD:275368
		C2H2 Zn finger	579..600	CDD:275368
		C2H2 Zn finger	610..630	CDD:275368
		C2H2 Zn finger	716..737	CDD:275368
		C2H2 Zn finger	746..766	CDD:275368
		C2H2 Zn finger	776..795	CDD:275368
		C2H2 Zn finger	820..838	CDD:275368
		C2H2 Zn finger	853..873	CDD:275368
		zf-H2C2_2	866..889	CDD:463886
		C2H2 Zn finger	881..901	CDD:275368
		zf-H2C2_2	893..918	CDD:463886
		C2H2 Zn finger	909..929	CDD:275368
Zfp457	NP_001003666.2	KRAB	5..63	CDD:214630
		transpos_ISL3	72..>118	CDD:468079
		C2H2 Zn finger	83..103	CDD:275368
		C2H2 Zn finger	111..131	CDD:275368
		C2H2 Zn finger	167..187	CDD:275368	4/13 (31%)
		COG5048	191..620	CDD:227381	112/540 (21%)
		C2H2 Zn finger	195..215	CDD:275368	8/34 (24%)
		C2H2 Zn finger	223..243	CDD:275368	5/23 (22%)
		C2H2 Zn finger	251..271	CDD:275368	6/29 (21%)
		C2H2 Zn finger	279..299	CDD:275368	5/25 (20%)
		C2H2 Zn finger	307..327	CDD:275368	4/21 (19%)
		C2H2 Zn finger	335..355	CDD:275368	4/19 (21%)
		C2H2 Zn finger	363..383	CDD:275368	3/19 (16%)
		C2H2 Zn finger	391..411	CDD:275368	6/24 (25%)
		C2H2 Zn finger	419..439	CDD:275368	3/33 (9%)
		C2H2 Zn finger	447..467	CDD:275368	4/19 (21%)
		C2H2 Zn finger	475..495	CDD:275368	2/19 (11%)
		C2H2 Zn finger	503..523	CDD:275368	2/19 (11%)
		C2H2 Zn finger	531..551	CDD:275368	5/24 (21%)
		C2H2 Zn finger	587..607	CDD:275368	4/19 (21%)