DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10669 and CG18476

DIOPT Version :9

Sequence 1:	NP_001163728.1	Gene:	CG10669 / 43069	FlyBaseID:	FBgn0039329	Length:	933	Species:	Drosophila melanogaster
Sequence 2:	NP_731615.1	Gene:	CG18476 / 41404	FlyBaseID:	FBgn0037931	Length:	936	Species:	Drosophila melanogaster

Alignment Length:	1008	Identity:	361/1008 - (35%)
Similarity:	498/1008 - (49%)	Gaps:	229/1008 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 CRVCGC--DDGRYWIETPVEKYAEKTFVQLLVELTRIEVVMAQAEKFPQWLCYACAEKLESTYDF 67
            ||.|..  .|....:.||.:||.:|...::|.|||.|.:....::||||.||..|.:||...|.:
  Fly     7 CRTCDSTDTDNLLKLATPSKKYPDKLLSEILCELTEINLDATGSQKFPQCLCSGCTKKLMGAYCY 71

  Fly    68 VLQARRTHELWLQKIGDSLNGDDEMEGTAALECLRETPIHL---------FEIE-------GVTI 116
            |.||...:||.::.:   .||    ....:.:||:|.|:.|         .|.|       .|||
  Fly    72 VKQAMAANELLMKHL---KNG----AAPTSTDCLQEAPMELCAEQHVEVKLETEDEDCGENDVTI 129

  Fly   117 KTEEL-----ASTQQAPKADPL---------VRPRIVKRSIV-----HFSDSDEDLDDVPLRQRK 162
            ...||     ...:.....|||         :.||.|::...     .|.|.| .||::||..|
  Fly   130 TCSELPEPDETDMESKKSVDPLTMIETVKLEMEPRSVEKPAYDDPTSDFEDED-SLDNLPLYNR- 192

  Fly   163 IAASVCGSDTTKENV--CELCNKVFRYVTNLYRHKQRDHGILGKNGEDYEEDYYKCDLCDKTYKY 225
                :....|.:::|  |..|.:.|:....|.||:.|.|        ..|...|.|.||.:.:..
  Fly   193 ----IQKWKTGRKSVYKCHDCPRSFKRFDFLKRHEMRVH--------KPETRLYDCSLCIRKFSR 245

  Fly   226 VMALVKHKHKEHGSSLLSNNSGRKMPSTLAEDANPYSPASISETSTNQSRTNNDSLVHSIIKAVV 290
            ..||..|. |.|      .||.|.              |:|||              |...|||
  Fly   246 SEALEAHL-KIH------RNSKRS--------------ANISE--------------HKKAKAV- 274

  Fly   291 LSDEDGHSGEDSYYNCDQCSKSYKYIVSLIKHKHKEHLDKESYKQSDDEDDRPLASTSASASAPT 355

  Fly   275 ----------------------------------------------------------------- 274

  Fly   356 AKPSRINRRVDGFDFHRSEPNGAKEIKCMICLRRFTKLRELRNHLQNHPTDFDF--EAHGEPIER 418
                         |.:..:|:|.|.|:||||..::.|:.:||.||:.||.....  ..:.||.|
  Fly   275 -------------DLNLCKPHGYKLIECMICQSQYNKIADLRRHLEEHPDIVSLCGRPNMEPHE- 325

  Fly   419 IAEGFFKTAVESTAEGLKRRIFRDLRMGVYGRYYSITNQARYEMTLDSSDTDSDGDGD-DNVVIR 482
            :||.|:..:.:.:.|.|...|.:||..|:|.|:||||||:.|||.||||:||||.||| |:...|
  Fly   326 LAELFYPDSKDLSEEQLINLIRKDLAAGIYQRFYSITNQSGYEMDLDSSETDSDLDGDHDDQHKR 390

  Fly   483 R------SYSCELCDSPEARWPRKYLLHQHHQKEHTWLDAPHVCQRCDSRFLNLQLLKHHTSQLC 541
            |      :||||||   :.::||||.|:.|.::.|:|.||||||.|||.||::||||:||....|
  Fly   391 RKKSRKATYSCELC---QQKFPRKYQLYDHQRQSHSWSDAPHVCGRCDGRFVSLQLLRHHNESQC 452

  Fly   542 QNTLKRFMCDKCPQRFFWRRNLRAHLVEHKCKQESYPCDQCSRSFQDKSAVTKHKLMMHRDSNME 606
            :|..|||:|.|||.||.|:.||:.|..||:...:::.|.:|.|.|..|.::|.|.|.:|.:.: :
  Fly   453 RNAQKRFLCHKCPLRFRWKHNLKTHFREHRITNQTFECSECKRVFDKKKSLTVHLLSVHAEES-K 516

  Fly   607 LLPCRWCTRTFYRPALLYKHLQRHGFTGQDLPLAETLLADASKPAGPKSVQCKICDIQFVSVADL 671
            |:||:||:|.|||...|.|||:|||....|:||||||:|..|:|.|.|.:.|::|::.|..:.||
  Fly   517 LIPCQWCSRKFYRHDYLVKHLKRHGLKEHDIPLAETLIAATSRPNGAKRITCRMCNLHFERIVDL 581

  Fly   672 RRHI--------SMQGHSDQPSAYMISTATGFELLLDDTDDSDEETSG----RTYSCDLCDLNFR 724
            |.||        |:....|.|..|.|:..:||||.|:|::..||...|    ..|.|:||.:..:
  Fly   582 RAHIQLELKLSLSLHQSYDSPHNYSITNESGFELQLEDSETEDEMQPGVGSRPVYICELCSVQCK 646

  Fly   725 RRREISEHQYSLHSFDKLPHNCEHCIFKTVDKNMLHQHLRTQCMNTEKKFACMRCGYKFMWEENL 789
            |:.|:.:||.::|.|||:||.|:.||||.|.|:::..|.:.||.:||||.||.:|.|||||.|||
  Fly   647 RKFEMIQHQRTMHRFDKMPHECDDCIFKCVSKSIMDHHRQGQCSSTEKKHACGKCSYKFMWPENL 711

  Fly   790 AQHLSTQHSK------------------QPAVPEQQPPLRRKRRFRYQCPHCWRSFVVQPSLDKH 836
            .||:..||||                  :....|...||       .|||||.|::.::..|:.|
  Fly   712 EQHILLQHSKSSVSNPTGDRHTQGTGDLEKDATEDGIPL-------LQCPHCDRTYQMKSRLNNH 769

  Fly   837 IRDMHV----AKKNPGKKYLCSLCGLESLTPNKLNIHMRRHTGEKPFKCDLCDMRFTVHYELKVH 897
            |||:|:    .:|...|::||||||:|:.:...|..||||||||||||||||:|.|..|.||..|
  Fly   770 IRDVHINGDRKRKEAIKRFLCSLCGMETRSAAALVTHMRRHTGEKPFKCDLCEMAFPRHSELASH 834

  Fly   898 RRKHTGERPYQCTFCDKDFARPDKLRRHVFMHN 930
            ||.||||:|:.||.|.|||||.|||:||:..|:
  Fly   835 RRMHTGEKPFHCTVCGKDFARSDKLKRHMLTHS 867

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10669	NP_001163728.1	zf-AD	4..81	CDD:285071	29/77 (38%)
		C2H2 Zn finger	178..199	CDD:275368	7/20 (35%)
		C2H2 Zn finger	216..233	CDD:275368	5/16 (31%)
		C2H2 Zn finger	520..542	CDD:275368	12/21 (57%)
		C2H2 Zn finger	550..570	CDD:275368	10/19 (53%)
		C2H2 Zn finger	579..600	CDD:275368	8/20 (40%)
		C2H2 Zn finger	610..630	CDD:275368	11/19 (58%)
		C2H2 Zn finger	716..737	CDD:275368	7/20 (35%)
		C2H2 Zn finger	746..766	CDD:275368	8/19 (42%)
		C2H2 Zn finger	776..795	CDD:275368	12/18 (67%)
		C2H2 Zn finger	820..838	CDD:275368	7/17 (41%)
		C2H2 Zn finger	853..873	CDD:275368	10/19 (53%)
		zf-H2C2_2	866..889	CDD:290200	18/22 (82%)
		COG5048	877..>930	CDD:227381	34/52 (65%)
		C2H2 Zn finger	881..901	CDD:275368	12/19 (63%)
		zf-H2C2_2	893..918	CDD:290200	16/24 (67%)
		C2H2 Zn finger	909..929	CDD:275368	13/19 (68%)
CG18476	NP_731615.1	zf-AD	6..84	CDD:285071	29/76 (38%)
		C2H2 Zn finger	206..227	CDD:275368	7/20 (35%)
		C2H2 Zn finger	236..256	CDD:275368	7/20 (35%)
		C2H2 Zn finger	401..422	CDD:275368	10/23 (43%)
		C2H2 Zn finger	431..447	CDD:275368	10/15 (67%)
		C2H2 Zn finger	461..481	CDD:275368	10/19 (53%)
		C2H2 Zn finger	490..511	CDD:275368	8/20 (40%)
		C2H2 Zn finger	520..540	CDD:275368	11/19 (58%)
		C2H2 Zn finger	638..659	CDD:275368	7/20 (35%)
		C2H2 Zn finger	668..690	CDD:275368	9/21 (43%)
		C2H2 Zn finger	698..715	CDD:275368	11/16 (69%)
		C2H2 Zn finger	753..774	CDD:275368	10/20 (50%)
		C2H2 Zn finger	790..810	CDD:275368	10/19 (53%)
		zf-H2C2_2	802..825	CDD:290200	18/22 (82%)
		COG5048	814..>886	CDD:227381	35/54 (65%)
		C2H2 Zn finger	818..838	CDD:275368	12/19 (63%)
		zf-H2C2_2	830..855	CDD:290200	16/24 (67%)
		C2H2 Zn finger	846..866	CDD:275368	13/19 (68%)
		zf-H2C2_2	859..883	CDD:290200	4/9 (44%)
		C2H2 Zn finger	874..894	CDD:275368
		C2H2 Zn finger	902..924	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45459009
Domainoid	1	1.000	42	1.000	Domainoid score	I19599
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D42822at6656
OrthoFinder	1	1.000	-	-		FOG0014266
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24376
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.950