DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10669 and Zfp52

DIOPT Version :9

Sequence 1:	NP_001163728.1	Gene:	CG10669 / 43069	FlyBaseID:	FBgn0039329	Length:	933	Species:	Drosophila melanogaster
Sequence 2:	NP_001014180.1	Gene:	Zfp52 / 361487	RGDID:	1359149	Length:	755	Species:	Rattus norvegicus

Alignment Length:	900	Identity:	206/900 - (22%)
Similarity:	311/900 - (34%)	Gaps:	268/900 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   119 EELASTQQAPKADPLV---RPRIVKRSI-VHFSDSD-EDLD--------DVPLRQRKIAASV--- 167
            |::...:|...||..|   :..:..|.: ||||..: |.||        ||.|.......||
  Rat    23 EKIKEEKQEEMADSPVNMSQSLLTFRDVAVHFSQEEWECLDSSQRALYIDVMLENYSNLVSVENY 87

  Fly   168 CGSDTTKENV------CELCN---KVFRYVTN--LYRH-------------KQRDHGILGKNGED 208
            |..:|..::|      |: ||   ::.|..:|  ||:.             |.|...:...|.:.
  Rat    88 CICETVHQHVKTEKESCQ-CNELGEMLRGPSNCALYKRSDTIETSNNCRCCKDRGASVDSSNPDQ 151

  Fly   209 Y---------------EEDYYKCDLCDKTYKYVMALVKHKHKEHGSSLLSNNSGRKMPSTLAEDA 258
            :               |:.:..|....:..:...|..:||..|:.....|..|..:....:.|..
  Rat   152 HTSTHTGEEPCTSKNCEKSFSLCSNIREDQRLYTAKKEHKQDEYDDRFSSTYSLMQQTVDMGEKP 216

  Fly   259 NPYSPAS--ISETSTNQSRTNNDSLVHSIIKAVVLSDEDGHSGEDSYYNCDQCSKSYKYIVSLIK 321
            :...|..  |:.||:..        :|..|          |:||.. |.|:.|.||:.....|..
  Rat   217 HQCGPCRKYINTTSSLS--------LHQRI----------HTGEKP-YKCNICEKSFNQWSRLKT 262

  Fly   322 HKHKEHLDKESYKQSDDEDDRPLASTSASASAPTAKPSRIN-RRVDGFDFHRSEPNGAKEIKCMI 385
            |:.. |:.::.||                     .|..|:: .:|.....|:....|.|..||..
  Rat   263 HQIL-HISEKQYK---------------------CKEGRMSFVQVFAHKSHQRRHTGEKPYKCKE 305

  Fly   386 CLRRFTKLRELRNHLQNHPTDFDFEAHGEPIERIAEGFFKTAVESTAEGLKRRIFRDLRMGVYGR 450
            |.|.|.....||.|.:.|..:..:|.     :...:.|      |....||          ::.|
  Rat   306 CDRSFAHCASLRWHQKIHSPEVHYEC-----KECGKAF------SELSHLK----------MHYR 349

  Fly   451 YYSITNQARYEMTLDSSDTDSDGDGDDNVVIR-----------------------------RSYS 486
            .:::....|||....||..:|.......:..|                             |.|.
  Rat   350 IHTVEKPYRYEECDTSSTVNSTLKNHQKIHTREKPYRYRECDKSITKCSYLRTYQRVHTGMRPYR 414

  Fly   487 CELCDSPEARWPRKYLLHQHHQKEHTWLDAPHVCQRCDSRFLNLQLLKHHTSQLCQNTLKRFMCD 551
            |..||.....:..   |.| |||.||. :.|..|:..|..||.:..::.|  |......:|:.|.
  Rat   415 CTECDKSFTTYSN---LRQ-HQKIHTG-EKPPNCKGSDKSFLRISSVRKH--QKIHAGERRYGCK 472

  Fly   552 KCPQRFFWRRNLRAHLVEHKCKQESYPCDQCSRSFQDKSAVTKHKLMMHRDSNMELLPCRWCTRT 616
            :|.:.|.|..|||.|...| ..:..|.|..|     |||..|...|.:|:..:
  Rat   473 ECSRSFTWFSNLRVHQRVH-TGERPYRCKDC-----DKSFTTGSNLRVHQKIH------------ 519

  Fly   617 FYRPALLYKHLQRHGFTGQDLPLAETLLADASKPAGPKSVQCKICDIQFVSVADLRRHISMQGHS 681
                                              .|.|..:||.|||.|:.:::||.|..:
  Rat   520 ----------------------------------TGEKPYKCKDCDISFLWISNLRTHQKI---- 546

  Fly   682 DQPSAYMISTATGFELLLDDTDDSDEETSGRTYSCDLCDLNFRRRREISEHQYSLHSFDKLPHNC 746
                                      .|..:.|.|..|..:|.|...:.:|| .:|:.:|| :.|
  Rat   547 --------------------------HTGEKPYKCQECKKSFTRCSYLRDHQ-KIHTGEKL-YKC 583

  Fly   747 EHC--IFKTVDKNMLHQHLRTQCMNTEKKFACMRCGYKFMWEENLAQHLSTQHSKQPAVPEQQPP 809
            :.|  .|..:.....||.:.|    .||.:.|..|...|.....|..|......::|
  Rat   584 KDCNVSFMWISSLRRHQKIHT----GEKPYKCRECEKSFTQCSTLRDHQKIHTGEKP-------- 636

  Fly   810 LRRKRRFRYQCPHCWRSFVVQPSLDKHIRDMHVAKKNPGKKYLCSLCGLESLTPNKLNIHMRRHT 874
                    |:|..|..||:...||.:| :.:|..:    |.|.|.:||:..|..:.|..|.:.||
  Rat   637 --------YKCKDCDISFLWISSLRRH-QKIHTGE----KPYKCKVCGISFLWISNLKTHQKIHT 688

  Fly   875 GEKPFKCDLCDMRFTVHYELKVHRRKHTGERPYQCTFCDKDFARPDKLRRHVFMH 929
            ||||:||..|:..||....|:||::.||||:||:|..|...|.....||||..:|
  Rat   689 GEKPYKCQECNKSFTRCSYLRVHQKTHTGEKPYKCKDCGVSFMWISNLRRHQKIH 743

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10669	NP_001163728.1	zf-AD	4..81	CDD:285071
		C2H2 Zn finger	178..199	CDD:275368	9/38 (24%)
		C2H2 Zn finger	216..233	CDD:275368	2/16 (13%)
		C2H2 Zn finger	520..542	CDD:275368	6/21 (29%)
		C2H2 Zn finger	550..570	CDD:275368	8/19 (42%)
		C2H2 Zn finger	579..600	CDD:275368	7/20 (35%)
		C2H2 Zn finger	610..630	CDD:275368	0/19 (0%)
		C2H2 Zn finger	716..737	CDD:275368	6/20 (30%)
		C2H2 Zn finger	746..766	CDD:275368	5/21 (24%)
		C2H2 Zn finger	776..795	CDD:275368	5/18 (28%)
		C2H2 Zn finger	820..838	CDD:275368	7/17 (41%)
		C2H2 Zn finger	853..873	CDD:275368	6/19 (32%)
		zf-H2C2_2	866..889	CDD:290200	11/22 (50%)
		COG5048	877..>930	CDD:227381	23/52 (44%)
		C2H2 Zn finger	881..901	CDD:275368	7/19 (37%)
		zf-H2C2_2	893..918	CDD:290200	12/24 (50%)
		C2H2 Zn finger	909..929	CDD:275368	7/19 (37%)
Zfp52	NP_001014180.1	KRAB	44..84	CDD:396083	11/39 (28%)
		C2H2 Zn finger	219..239	CDD:275368	6/37 (16%)
		SFP1	<241..324	CDD:227516	26/105 (25%)
		C2H2 Zn finger	247..295	CDD:275368	13/69 (19%)
		C2H2 Zn finger	303..323	CDD:275368	7/19 (37%)
		COG5048	329..702	CDD:227381	113/509 (22%)
		C2H2 Zn finger	331..351	CDD:275368	5/40 (13%)
		C2H2 Zn finger	359..379	CDD:275368	5/19 (26%)
		C2H2 Zn finger	388..407	CDD:275368	0/18 (0%)
		C2H2 Zn finger	415..435	CDD:275368	8/23 (35%)
		C2H2 Zn finger	443..463	CDD:275370	6/21 (29%)
		C2H2 Zn finger	471..491	CDD:275368	8/19 (42%)
		C2H2 Zn finger	499..519	CDD:275368	8/24 (33%)
		C2H2 Zn finger	527..547	CDD:275368	9/49 (18%)
		C2H2 Zn finger	555..575	CDD:275368	6/20 (30%)
		C2H2 Zn finger	583..603	CDD:275368	5/19 (26%)
		C2H2 Zn finger	611..631	CDD:275368	5/19 (26%)
		C2H2 Zn finger	639..659	CDD:275368	7/20 (35%)
		C2H2 Zn finger	667..687	CDD:275368	6/19 (32%)
		C2H2 Zn finger	695..715	CDD:275368	7/19 (37%)
		zf-H2C2_2	707..730	CDD:404364	11/22 (50%)
		C2H2 Zn finger	723..743	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336943
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930