DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG10669 and ZNF445

DIOPT Version :10

Sequence 1:NP_651388.1 Gene:CG10669 / 43069 FlyBaseID:FBgn0039329 Length:933 Species:Drosophila melanogaster
Sequence 2:NP_852466.1 Gene:ZNF445 / 353274 HGNCID:21018 Length:1031 Species:Homo sapiens


Alignment Length:1124 Identity:217/1124 - (19%)
Similarity:359/1124 - (31%) Gaps:391/1124 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MTRTCRVCGCDDGRYWIETPVEKYAE-------KTFVQLLVELTRIEVVMAQAEKFPQWLCYACA 58
            ::|...:|     |:|:...|...|:       :.|:.:|....|:.|.:...|...:  ..|..
Human    73 LSRLRELC-----RWWLRPDVLSKAQILELLVLEQFLSILPGELRVWVQLHNPESGEE--AVALL 130

  Fly    59 EKLESTYD-----------------FVLQARRTHELW--------LQKIGDSLNGDDEMEGTAAL 98
            |:|:...|                 ....|.|:.::|        ...:||.|....|:|....|
Human   131 EELQRDLDGTSWRDPGPAQSPDVHWMGTGALRSAQIWSLASPLRSSSALGDHLEPPYEIEARDFL 195

  Fly    99 ECLRETPI----HLFEIEG-----VTIKTEELASTQQAPKADPLVRPRIVKRSIVHFSDSDED-L 153
            ....:||.    .||..||     ||......|..|:.         ...|...|.||..:.. |
Human   196 AGQSDTPAAQMPALFPREGCPGDQVTPTRSLTAQLQET---------MTFKDVEVTFSQDEWGWL 251

  Fly   154 D--------DVPLRQRKIAASVCGSDTTKENVCELCNKVFRYVTNLYRHKQRDHGILGKNGEDYE 210
            |        ||.|...:..||:.| ..||..:.........:..|:...:.:.:.:....|:   
Human   252 DSAQRNLYRDVMLENYRNMASLVG-PFTKPALISWLEAREPWGLNMQAAQPKGNPVAAPTGD--- 312

  Fly   211 EDYYKCDLCDKTYKYVMALVKHKHKEHGSSLLSNNSGRKMPSTLAEDANPYSPA-SISE----TS 270
                  ||..||.|:::                |....:...|||..:.  .|| |:||    ..
Human   313 ------DLQSKTNKFIL----------------NQEPLEEAETLAVSSG--CPATSVSEGIGLRE 353

  Fly   271 TNQSRTNNDSLVHSIIKAVVLSDEDGHS---GEDSYYNCDQCSKSYKYIVSL--------IKH-- 322
            :.|.::.......:.|:..|..:|...|   |:||..:... |...|::..|        :||  
Human   354 SFQQKSRQKDQCENPIQVRVKKEETNFSHRTGKDSEVSGSN-SLDLKHVTYLRVSGRKESLKHGC 417

  Fly   323 -KH----KEHLDKESYKQSDDEDDRPLASTSASASAPTAKPSRINRRVDGFDFHRSEPNGAKEIK 382
             ||    ..|.|.:.|.:.                        :...:.||..|:...:|.|..|
Human   418 GKHFRMSSHHYDYKKYGKG------------------------LRHMIGGFSLHQRIHSGLKGNK 458

  Fly   383 CMICLRRFTKLRELRNHLQNHPTDFDFEAHGEPIERIAEGFFKTAVESTAEGLKRRIFRDLRMGV 447
            ..:|.:.|:    |.:|.|          .|:.:..:...|                    :...
Human   459 KDVCGKDFS----LSSHHQ----------RGQSLHTVGVSF--------------------KCSD 489

  Fly   448 YGRYYSITNQARYEMTLDSSDTDSDGDGDDNVVIRRSYSCELCDSPEARWPRKYLLHQHHQKEHT 512
            .||.:|.::...|...|.:.:              :::.|.:| ....||....   ..|:|.||
Human   490 CGRTFSHSSHLAYHQRLHTQE--------------KAFKCRVC-GKAFRWSSNC---ARHEKIHT 536

  Fly   513 WLDAPHVCQRCDSRFLNLQLLK----------------------------HHTSQLCQNTLKRFM 549
            .: .|:.|..|:..|..|...:                            ||...  |:..|.|.
Human   537 GV-KPYKCDLCEKAFRRLSAYRLHRETHAKKKFLELNQYRAALTYSSGFDHHLGD--QSGEKLFD 598

  Fly   550 CDKCPQRFFWRRNLRAHLVEHK---CKQESYPCDQCSRSFQDKSAVTKHKLMMHRDSNM------ 605
            |.:|.:.|    :.:::::||:   .:::.|.|.:|.::|:.:|..|:| :.:|.:...      
Human   599 CSQCRKSF----HCKSYVLEHQRIHTQEKPYKCTKCRKTFRWRSNFTRH-MRLHEEEKFYKQDEC 658

  Fly   606 --------------------ELLPCRWCTRTFYRPALLYKHLQRHGFTGQDLPLAETLLADASKP 650
                                :...|:.|.:||.|...|..|.:.|                    
Human   659 REGFRQSPDCSQPQGAPAVEKTFLCQQCGKTFTRKKTLVDHQRIH-------------------- 703

  Fly   651 AGPKSVQCKICDIQF----VSVADLRRHISMQGHSDQPSAYMISTATGFELLLDDTDDSDEETSG 711
            .|.|..||..|...|    ..:...::|...:.....||   .|..|.|:  :..:..|.||   
Human   704 TGEKPYQCSDCGKDFAYRSAFIVHKKKHAMKRKPEGGPS---FSQDTVFQ--VPQSSHSKEE--- 760

  Fly   712 RTYSCDLCDLNFRRRREISEHQYSLHSFDKLPHNCEHCIFKTVDKNMLHQHLRTQCMNTEKKFAC 776
             .|.|..|...||.           |||                 .::||.:.|    .||.:.|
Human   761 -PYKCSQCGKAFRN-----------HSF-----------------LLIHQRVHT----GEKPYKC 792

  Fly   777 MRCGYKFMWEENLAQH-----LSTQHS--KQPAVPEQQPPLRRKRRFRYQCPHCWRSFVVQPSLD 834
            ..||..|.|..||.:|     |..|:.  :....|..:|.:....: |:.|..|.::|..:.:|.
Human   793 RECGKAFRWSSNLYRHQRIHSLQKQYDCHESEKTPNVEPKILTGEK-RFWCQECGKTFTRKRTLL 856

  Fly   835 KHIRDMHVAKKNPGKKYLCSLCGLESLTPNKLNIHMRRHTGEKPFKCDLCDMRFTVHYELKVHRR 899
            .| :.:|..:    |:|.|:|||.......:|..|.|.|:.|:||||..|...|...:.|..|:|
Human   857 DH-KGIHSGE----KRYKCNLCGKSYDRNYRLVNHQRIHSTERPFKCQWCGKEFIGRHTLSSHQR 916

  Fly   900 KHT------------------------------------------------------GERPYQCT 910
            |||                                                      |::.::|:
Human   917 KHTRAAQAERSPPARSSSQDTKLRLQKLKPSEEMPLEDCKEACSQSSRLTGLQDISIGKKCHKCS 981

  Fly   911 FCDKDFARPDKLRRHVFMH 929
            .|.|.|.:..:|..|...|
Human   982 ICGKTFNKSSQLISHKRFH 1000

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG10669NP_651388.1 zf-AD 4..80 CDD:462262 17/107 (16%)
C2H2 Zn finger 178..199 CDD:275368 1/20 (5%)
C2H2 Zn finger 216..233 CDD:275368 5/16 (31%)
C2H2 Zn finger 520..542 CDD:275368 6/49 (12%)
C2H2 Zn finger 550..570 CDD:275368 3/19 (16%)
C2H2 Zn finger 579..600 CDD:275368 6/20 (30%)
C2H2 Zn finger 610..630 CDD:275368 7/19 (37%)
C2H2 Zn finger 716..737 CDD:275368 4/20 (20%)
C2H2 Zn finger 746..766 CDD:275368 2/19 (11%)
C2H2 Zn finger 776..795 CDD:275368 9/23 (39%)
C2H2 Zn finger 820..838 CDD:275368 5/17 (29%)
C2H2 Zn finger 853..873 CDD:275368 7/19 (37%)
zf-H2C2_2 866..889 CDD:463886 10/22 (45%)
C2H2 Zn finger 881..901 CDD:275368 6/19 (32%)
zf-H2C2_2 893..918 CDD:463886 11/78 (14%)
C2H2 Zn finger 909..929 CDD:275368 6/19 (32%)
ZNF445NP_852466.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..43
SCAN 51..155 CDD:128708 15/88 (17%)
KRAB 234..292 CDD:214630 14/58 (24%)
C2H2 Zn finger 415..451 CDD:275368 9/59 (15%)
COG5048 <457..643 CDD:227381 42/244 (17%)
C2H2 Zn finger 460..479 CDD:275368 6/32 (19%)
C2H2 Zn finger 487..507 CDD:275368 4/19 (21%)
C2H2 Zn finger 515..535 CDD:275368 6/23 (26%)
C2H2 Zn finger 543..563 CDD:275368 4/19 (21%)
COG5048 595..1031 CDD:227381 101/478 (21%)
C2H2 Zn finger 599..619 CDD:275368 5/23 (22%)
C2H2 Zn finger 627..647 CDD:275368 6/20 (30%)
C2H2 Zn finger 683..703 CDD:275368 7/19 (37%)
C2H2 Zn finger 711..731 CDD:275368 3/19 (16%)
C2H2 Zn finger 764..784 CDD:275368 9/47 (19%)
C2H2 Zn finger 792..812 CDD:275368 8/19 (42%)
C2H2 Zn finger 842..862 CDD:275368 5/20 (25%)
C2H2 Zn finger 870..890 CDD:275368 7/19 (37%)
C2H2 Zn finger 898..918 CDD:275368 6/19 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 911..939 6/27 (22%)
C2H2 Zn finger 953..972 CDD:275368 0/18 (0%)
C2H2 Zn finger 980..1000 CDD:275368 6/19 (32%)
C2H2 Zn finger 1008..1028 CDD:275368
Blue background indicates that the domain is not in the aligned region.

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