DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10669 and Zfp574

DIOPT Version :9

Sequence 1:	NP_001163728.1	Gene:	CG10669 / 43069	FlyBaseID:	FBgn0039329	Length:	933	Species:	Drosophila melanogaster
Sequence 2:	XP_038967305.1	Gene:	Zfp574 / 308434	RGDID:	1311420	Length:	909	Species:	Rattus norvegicus

Alignment Length:	1021	Identity:	210/1021 - (20%)
Similarity:	317/1021 - (31%)	Gaps:	330/1021 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 YACAE--KLESTYDFVLQARRTH--ELWLQKIGDSLNG----DDEMEGTA------------ALE 99
            |.|:|  :|..:.:.||..:.:|  :...:.:|.:..|    .:...||.            .||
  Rat    27 YVCSECNQLYGSLEEVLVHQNSHVPQQHFELVGVADPGVTVATEATSGTGLYQTLIQESQYQCLE 91

  Fly   100 C--LRETPIHLFEIEGVTIK---TEELASTQQAPKADPLVRPRIVKRSIVHFSDSDEDLDDVPL- 158
            |  |..:|..|.|.:.:.:|   .:|....:..||..||      ..|.:|:    |.:|...|
  Rat    92 CGQLLLSPSQLLEHQELHLKMMAPQEAVPAEPPPKVPPL------SSSTIHY----ECVDCKALF 146

  Fly   159 ---------RQRKIAAS--------------VCGSDTTKENVCELCNKVFRYVTNLYRHKQRDHG 200
                     ||..:.|:              |.|....:..|.         |.:.||..:
  Rat   147 ASQEMWLSHRQTHLRATPNKAPAPVVLGSPVVLGPPVGQARVA---------VEHSYRKAE---- 198

  Fly   201 ILGKNGE---------------DYEEDYYKCDLCDKTYKYVMALVKHKHKEHGSSLLSNNSGRKM 250
               :.||               :.|...|||..|.:.:                         :|
  Rat   199 ---EGGEGAAVPSVAAATEMVTEVELLLYKCSECSQLF-------------------------QM 235

  Fly   251 PSTLAEDANPYSPASISETSTNQSRTNNDSLVHSIIKAVVLSDEDGHSGEDSYYNCDQCSKSYKY 315
            |:...|....:.||.:.|  ..:..|..::||.|..:|.|...:...:.:.||
  Rat   236 PADFLEHQATHFPAPVPE--AEEPATQQETLVPSPTEAAVSQPDPLPASDHSY------------ 286

  Fly   316 IVSLIKHKHKEHLDKESYKQSDDEDDRPLASTSASASAPT-----------AKPSRINRRVDGFD 369
                   :.:..|........|....:|..|:|..:.|..           ..|.::.:.:
  Rat   287 -------ELRNELRNGEAMGRDRRGRKPRRSSSGESGATQELFCSACDQIFLSPHQLQQHL---- 340

  Fly   370 FHRSEPNGAKEIKCMICLRRFTKLRELRNHLQNHPTDFDF-------------------EAH-GE 414
              ||...|.  .||.:|.|.|.....|..||.:|.::..|                   .|| ..
  Rat   341 --RSHREGV--FKCPLCSRVFPSPSSLDQHLGDHSSESHFLCVDCGLAFGTEALLLAHRRAHTPN 401

  Fly   415 PIERIAEGFFKTAVESTAEGLKRRIFRDLRMGVYG------------RYYSITNQARYEM-TLDS 466
            |:.....|  ||.|..|.....||..     |..|            ...|....|..|. .|::
  Rat   402 PLHSCPCG--KTFVNLTKFLYHRRTH-----GAGGVPLPTTPVPPEEPAISFPEPAPAETGELEA 459

  Fly   467 SDTDSDGDGDDNVVIRRSYSCELCDSPEARWPRKYLLHQHHQKEHTWLDAPHVCQRCDSRFLNLQ 531
            .:.....:.........:|.|.||    :|...|.|....||:....|:..|.|..|...|....
  Rat   460 PELPVSEESSAEPAAPGTYRCLLC----SREFSKALQLTRHQRFVHRLERRHKCSICGKMFKKKS 520

  Fly   532 LLKHHTSQLCQNTLKR-FMCDKCPQRFFWRRNLRAHLVEHKCKQESYPCDQCSRSFQDKSAVTKH 595
            .:::|   |..:|.:| |.|..|.:.|....||..|.:.| ..:..|.|..|.::|...|.:.:|
  Rat   521 HVRNH---LRTHTGERPFPCPDCSKPFNSPANLARHRLTH-TGERPYRCGDCGKAFTQSSTLRQH 581

  Fly   596 KLMMHRDSNMELLP--CRWCTRTFYRPALLYKHLQRHGFTGQDLPLAETLLADASKPAGPKSVQC 658
            :|:     :.:..|  |:.|...|:||..|..|...|  ||:
  Rat   582 RLV-----HAQHFPYRCQECGVRFHRPYRLLMHRYHH--TGE----------------------- 616

  Fly   659 KICDIQFVSVADLRRHISMQGHSDQPSAYMISTATGFELLLDDTDDSDEETSGRTYSCDLCDLNF 723
                                                                 ..|.|..|..:|
  Rat   617 -----------------------------------------------------YPYKCRECPRSF 628

  Fly   724 RRRREISEHQYSLHSFDKLPHNCEHCIFKTVDKNMLHQHLRTQC----MNTEKKFACMRCGYKFM 784
            ..||.:..||..:|: .:.||.|..|.........|.:|   :|    ....::|.|..||.|..
  Rat   629 LLRRLLEVHQLVVHA-GRQPHRCPSCGAAFPSSLRLREH---RCAAAAAQAPRRFECGTCGKKVG 689

  Fly   785 WEENLAQHLSTQHSKQPA-VPEQQPPLRR---------------------------KRRFRYQCP 821
            ....|..|.:...:..|. |..::||..|                           .||...:|.
  Rat   690 SAARLQAHEAAHAAAGPGEVLAKEPPAPRAARATRTPVAPSPTALGGTTSAAPAAPARRRGLECS 754

  Fly   822 HCWRSFVVQPSLDKHIRDMHVAKKNPGKKYLCSLCGLESLTPNKLNIHMRRHTGEKPFKCDLCDM 886
            .|.:.|..:.||..| |.:|..:    :.|.|..||........|..|.|.||||:||.|::|..
  Rat   755 ECKKLFSTETSLQVH-RRIHTGE----RPYPCPDCGKAFRQSTHLKDHRRLHTGERPFACEVCGK 814

  Fly   887 RFTVHYELKVHRRKHTGERPYQCTFCDKDFARPDKLRRHVFMHNDK 932
            .|.:...|..|||.|||||||.|..|.|.:.....|.:|...|..:
  Rat   815 AFAISMRLAEHRRIHTGERPYSCPDCGKSYRSFSNLWKHRKTHQQQ 860

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10669	NP_001163728.1	zf-AD	4..81	CDD:285071	7/29 (24%)
		C2H2 Zn finger	178..199	CDD:275368	3/20 (15%)
		C2H2 Zn finger	216..233	CDD:275368	2/16 (13%)
		C2H2 Zn finger	520..542	CDD:275368	5/21 (24%)
		C2H2 Zn finger	550..570	CDD:275368	6/19 (32%)
		C2H2 Zn finger	579..600	CDD:275368	6/20 (30%)
		C2H2 Zn finger	610..630	CDD:275368	7/19 (37%)
		C2H2 Zn finger	716..737	CDD:275368	7/20 (35%)
		C2H2 Zn finger	746..766	CDD:275368	4/19 (21%)
		C2H2 Zn finger	776..795	CDD:275368	6/18 (33%)
		C2H2 Zn finger	820..838	CDD:275368	6/17 (35%)
		C2H2 Zn finger	853..873	CDD:275368	6/19 (32%)
		zf-H2C2_2	866..889	CDD:290200	11/22 (50%)
		COG5048	877..>930	CDD:227381	21/52 (40%)
		C2H2 Zn finger	881..901	CDD:275368	7/19 (37%)
		zf-H2C2_2	893..918	CDD:290200	14/24 (58%)
		C2H2 Zn finger	909..929	CDD:275368	5/19 (26%)
Zfp574	XP_038967305.1	zf-C2H2_8	323..402	CDD:406359	16/86 (19%)
		C2H2 Zn finger	323..343	CDD:275368	2/25 (8%)
		C2H2 Zn finger	350..370	CDD:275368	7/19 (37%)
		C2H2 Zn finger	378..398	CDD:275368	0/19 (0%)
		C2H2 Zn finger	406..425	CDD:275368	7/20 (35%)
		lambda-1	469..>503	CDD:212564	9/37 (24%)
		C2H2 Zn finger	480..501	CDD:275368	8/24 (33%)
		COG5048	507..861	CDD:227381	105/450 (23%)
		C2H2 Zn finger	509..529	CDD:275368	5/22 (23%)
		C2H2 Zn finger	537..557	CDD:275368	6/19 (32%)
		C2H2 Zn finger	565..585	CDD:275368	6/24 (25%)
		C2H2 Zn finger	593..613	CDD:275368	7/19 (37%)
		C2H2 Zn finger	621..642	CDD:275368	7/20 (35%)
		C2H2 Zn finger	650..667	CDD:275368	4/19 (21%)
		C2H2 Zn finger	753..773	CDD:275368	7/20 (35%)
		C2H2 Zn finger	781..801	CDD:275368	6/19 (32%)
		C2H2 Zn finger	809..829	CDD:275368	7/19 (37%)
		C2H2 Zn finger	837..857	CDD:275368	5/19 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100