DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10669 and ZNF493

DIOPT Version :9

Sequence 1:	NP_001163728.1	Gene:	CG10669 / 43069	FlyBaseID:	FBgn0039329	Length:	933	Species:	Drosophila melanogaster
Sequence 2:	NP_001070146.1	Gene:	ZNF493 / 284443	HGNCID:	23708	Length:	774	Species:	Homo sapiens

Alignment Length:	765	Identity:	174/765 - (22%)
Similarity:	279/765 - (36%)	Gaps:	198/765 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   178 CELCNKVFRYVTNLYRHKQRDHGILGKNGEDYEEDYYKCDLCDKTYKYVMALVKHKHKEHGSSLL 242
            |:.|.|.|..:.:|.:|| |.|         ..|:.|:|:.|.|.:.:...|.:|:....|....
Human   184 CKKCGKSFCMLLHLCQHK-RIH---------IRENSYRCEECGKAFIWFSTLTRHRRVHTGEKSY 238

  Fly   243 SNNSGRKMPSTLAEDANPYSPASISETSTNQSRTNNDSLVHSIIKAVVLSDEDGHSGEDSYYNCD 307
            ....|:                     |.||   :::...|..|          |:|:.. |.|:
Human   239 KYECGK---------------------SFNQ---DSNLTTHKRI----------HTGQKP-YKCE 268

  Fly   308 QCSKSYKYIVSLIKHKHKEHLDKESYKQSDDEDDRPLASTSASASAPTAKPSRINRRVDGFDFHR 372
            :|..|:.....|.:|| ..|..::.||...      ...|...:|..|.              |:
Human   269 ECGTSFYQFSYLTRHK-LIHTREKPYKCEQ------YGKTFNQSSTLTG--------------HK 312

  Fly   373 SEPNGAKEIKCMICLRRFTKLRELRNHLQNHPTDFDFEAHGEPIERIAEGFFKTAVESTAEGLKR 437
            ...||.|..||..|.:.|:        :.:.||.... .|.|......|.:.|...||:.....:
Human   313 IIHNGEKPYKCEECGKAFS--------IFSTPTKHKI-IHTEEKSHRCEEYCKAYKESSHLTTHK 368

  Fly   438 RIF---RDLRMGVYGRYYSITNQARYEMTLDSSDTDSDGDGDDNVVIRRSYSCELCDSPEARWPR 499
            ||.   :..:....|:.:||.:.......:.:.:              :|:.||.|.       :
Human   369 RIHTGEKPYKCEECGKAFSIFSTLTKHKIIHTEE--------------KSHRCEECG-------K 412

  Fly   500 KYLLHQH---HQKEHTWLDAPHVCQRCDSRFLNLQLL-KH---HTSQLCQNTLKRFMCDKCPQRF 557
            .|....|   |::.||. :.|:.|:.|...|....:| ||   ||.:      |.:.|::|.:.|
Human   413 AYKESSHLTTHKRIHTG-EKPYKCEECGKTFSVFSILTKHKIIHTEE------KPYKCEECGKAF 470

  Fly   558 FWRRNLRAHLVEHKCKQESYPCDQCSRSFQDKSAVTKHKLMMHRDSNMELLPCRWCTRTFYRPAL 622
            .....|..|.:.| .:::.|.|::|.::|...|.::.||::   .:..:...|..|.:.|.|.:.
Human   471 KRSSTLTKHRIIH-TEEKPYKCEECGKAFNQSSTLSIHKII---HTGEKPYKCEECGKAFKRSST 531

  Fly   623 LYKHLQRHGFTGQDLPLAETLLADASKPAGPKSVQCKICDIQFVSVADLRRHISMQ-GHSDQPSA 686
            |..|...|                    .|.|..:|:.|...|...:.|..|..:. ||
Human   532 LTIHKMIH--------------------TGEKPYKCEECGKAFNRSSHLTTHKRIHTGH------ 570

  Fly   687 YMISTATGFELLLDDTDDSDEETSGRTYSCDLCDLNFRRRREISEHQYSLHSFDKLPHNCEHC-- 749
                                     :.|.|..|..:|.....:::|:. :|: ||.|:.||.|
Human   571 -------------------------KPYKCKECGKSFSVFSTLTKHKI-IHT-DKKPYKCEECGK 608

  Fly   750 IFKTVDKNMLHQHLRTQCMNTEKKFACMRCGYKFMWEENLAQHLSTQHSKQPAVPEQQPPLRRKR 814
            .|.......:|:.:.|    .||.:.|..||..|....:||.|......::|
Human   609 AFNRSSILSIHKKIHT----GEKPYKCEECGKAFKRSSHLAGHKQIHSVQKP------------- 656

  Fly   815 RFRYQCPHCWRSFVVQPSLDKHIRDMHVAKKNPGKKYLCSLCGLESLTPNKLNIHMRRHTGEKPF 879
               |:|..|.::|.:..:|.|| :.:|..:    |.|.|..||......:.||.|...||||||.
Human   657 ---YKCEECGKAFSIFSTLTKH-KIIHTEE----KPYKCEKCGKTFYRFSNLNTHKIIHTGEKPC 713

  Fly   880 KCDLCDMRFTVHYELKVHRRKHTGERPYQCTFCDKDFARPDKLRRHVFMH 929
            ||:.|...|.....|..|:..|||::||:|..|.|.|.|...|.||..:|
Human   714 KCEECGKAFNHSSNLIKHKLIHTGDKPYKCEACGKAFRRSSHLSRHKIIH 763

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10669	NP_001163728.1	zf-AD	4..81	CDD:285071
		C2H2 Zn finger	178..199	CDD:275368	8/20 (40%)
		C2H2 Zn finger	216..233	CDD:275368	4/16 (25%)
		C2H2 Zn finger	520..542	CDD:275368	8/25 (32%)
		C2H2 Zn finger	550..570	CDD:275368	5/19 (26%)
		C2H2 Zn finger	579..600	CDD:275368	6/20 (30%)
		C2H2 Zn finger	610..630	CDD:275368	6/19 (32%)
		C2H2 Zn finger	716..737	CDD:275368	4/20 (20%)
		C2H2 Zn finger	746..766	CDD:275368	5/21 (24%)
		C2H2 Zn finger	776..795	CDD:275368	7/18 (39%)
		C2H2 Zn finger	820..838	CDD:275368	6/17 (35%)
		C2H2 Zn finger	853..873	CDD:275368	6/19 (32%)
		zf-H2C2_2	866..889	CDD:290200	12/22 (55%)
		COG5048	877..>930	CDD:227381	22/53 (42%)
		C2H2 Zn finger	881..901	CDD:275368	5/19 (26%)
		zf-H2C2_2	893..918	CDD:290200	11/24 (46%)
		C2H2 Zn finger	909..929	CDD:275368	8/19 (42%)
ZNF493	NP_001070146.1	KRAB	13..73	CDD:214630
		KRAB	13..52	CDD:279668
		C2H2 Zn finger	184..204	CDD:275368	8/20 (40%)
		C2H2 Zn finger	212..232	CDD:275368	5/19 (26%)
		C2H2 Zn finger	241..259	CDD:275368	6/51 (12%)
		COG5048	262..667	CDD:227381	110/540 (20%)
		C2H2 Zn finger	267..287	CDD:275368	6/20 (30%)
		C2H2 Zn finger	295..315	CDD:275368	4/39 (10%)
		C2H2 Zn finger	351..371	CDD:275368	5/19 (26%)
		zf-H2C2_2	363..387	CDD:290200	3/23 (13%)
		C2H2 Zn finger	379..399	CDD:275368	3/19 (16%)
		C2H2 Zn finger	407..427	CDD:275368	6/26 (23%)
		zf-H2C2_2	419..443	CDD:290200	7/24 (29%)
		C2H2 Zn finger	435..455	CDD:275368	6/19 (32%)
		zf-H2C2_2	448..472	CDD:290200	9/29 (31%)
		C2H2 Zn finger	463..483	CDD:275368	5/19 (26%)
		C2H2 Zn finger	491..511	CDD:275368	6/22 (27%)
		zf-H2C2_2	504..528	CDD:290200	5/26 (19%)
		C2H2 Zn finger	519..539	CDD:275368	6/19 (32%)
		zf-H2C2_2	532..556	CDD:290200	8/43 (19%)
		C2H2 Zn finger	547..567	CDD:275368	5/19 (26%)
		zf-H2C2_2	559..583	CDD:290200	7/54 (13%)
		C2H2 Zn finger	575..595	CDD:275368	4/20 (20%)
		C2H2 Zn finger	603..623	CDD:275368	5/19 (26%)
		zf-H2C2_2	616..640	CDD:290200	8/27 (30%)
		C2H2 Zn finger	631..651	CDD:275368	7/19 (37%)
		C2H2 Zn finger	659..679	CDD:275368	6/20 (30%)
		C2H2 Zn finger	687..707	CDD:275368	6/19 (32%)
		C2H2 Zn finger	715..735	CDD:275368	5/19 (26%)
		C2H2 Zn finger	743..763	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100