DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10669 and mld

DIOPT Version :9

Sequence 1:	NP_001163728.1	Gene:	CG10669 / 43069	FlyBaseID:	FBgn0039329	Length:	933	Species:	Drosophila melanogaster
Sequence 2:	NP_001247289.1	Gene:	mld / 2768685	FlyBaseID:	FBgn0263490	Length:	1965	Species:	Drosophila melanogaster

Alignment Length:	871	Identity:	158/871 - (18%)
Similarity:	265/871 - (30%)	Gaps:	336/871 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   253 TLAEDANPYS----PASISETS----TNQSRTNN----------DSLVHSIIKAVV-------LS 292
            |:.:.:|...    |::.|||:    |.||:...          :::..:.:::|.       :|
  Fly  1137 TVQQSSNKMQVISLPSAGSETTRQWQTQQSQQQQQVQWSSVGGLEAIKSAPVESVAPTTTTYYIS 1201

  Fly   293 DEDGHSGEDSYYNCDQCSKSYKYIVSLIKHK---------------HKEHLDKESYKQ------- 335
            ..|.:..:...|...|.:.:..|::..:.|:               .::|..:::.:|
  Fly  1202 ASDLYPQQTETYTMLQPASNESYVIEQVNHQQQHCQQQIQMSQQQHQRQHQQQQAQQQQQPIMIL 1266

  Fly   336 -SDDEDDRPLASTSASASAPTAKPSRINRRVDGFDFHRSEPNGAKEIKCMICLRRFTKLRELRNH 399
             ...|..:|:    ||||.|...|..|.......|.|:.:....::|:.....:::.:|::.:..
  Fly  1267 IQQPEIQQPV----ASASNPQQAPLHIYNAATSNDVHQMQHTQRQQIRQQYQHQQYQRLQQPQQT 1327

  Fly   400 --LQNHP-------TDFDFEAHGEPIERIAEGFFKTAVESTAEGLKRRIFRDLRMGVYGRYYSIT 455
              :|:||       |....:....|:         ||.......||.|...
  Fly  1328 RVVQSHPVLGMPGATSISTKVTPIPV---------TAARGRPLTLKCRFCH-------------- 1369

  Fly   456 NQARYEMTLDSSDTDSDGDGDDNVVIRRSYSCELCDSPEARWPRKYLLHQHHQKEHTWLDAPHVC 520
            |..|:..:|:                   ||..:.|           ||            |.|.
  Fly  1370 NGPRFSSSLE-------------------YSRHIID-----------LH------------PAVA 1392

  Fly   521 QRCDSRFLNLQLLKHHTSQLCQNTLKRFMCDKCPQRFFWRRNLRAHLVEHKCKQESYPCDQCSRS 585
            .                          |.|..||..|..|.....|::.|...|: |.|.|||..
  Fly  1393 P--------------------------FNCPHCPMAFAGRTKRSQHILSHHVVQQ-YQCGQCSHV 1430

  Fly   586 FQDKSAVTKHKLMMH-------------RDSNMELLPCRWCTRTFYRPALLYKHLQRHGFTG--- 634
            |..:.|:..|....|             .|..:::...|......|:|.|   .||:|....
  Fly  1431 FPAQKALDVHIQRFHMTLKTDPSGAVKVEDVQLQITSERRPRGRPYKPRL---QLQQHQLQPQQK 1492

  Fly   635 -------------QDLPLAE--------------------------------------------- 641
                         |.||.|:
  Fly  1493 LQVQQHQQQQKALQQLPQAQHHQQQQQPQLQQEVLQQVQQLQVQVQPQQHQQHQQVLQVQQPQQQ 1557

  Fly   642 -----------TLLADASKPAGPKSV----QCKIC-------DIQFVSVADLRRH---------- 674
                       |:...|| |..|:.:    .|:.|       :.||..:..|:..
  Fly  1558 PLMQPQSPHPSTVEMQAS-PTTPRKILCCPDCEDCTSGHSHANEQFEELQTLQAPPTVLTPPSTI 1621

  Fly   675 ISMQGHSDQPSAYMISTATGFELLLDDTDDSDEETSGRTYSCDLCDLNFRRRREISEHQYSLH-- 737
            :|:.  |.||..|    :....:...:..:.|..|:.|.|         |:|..|...|..||
  Fly  1622 VSVP--SPQPMVY----SQHITMPSPEQSEPDSTTTLRQY---------RKRGVIVGPQGPLHLA 1671

  Fly   738 ---------------SFDKLPHNC-----------EHCIFKTVDKNMLHQHLRTQCMNTEKKFAC 776
                           :.|.:|...           ...:..||..:    .|||       ...|
  Fly  1672 TPVASPSPSSSPSSSTVDHIPPASPATPASPAPPPSPAVASTVQVS----ELRT-------SHHC 1725

  Fly   777 MRCGYKFMWEENLAQHLSTQHSKQPAVPEQQPPLRRKRRFRYQCPHCWRSFVVQPSLDKHIRDMH 841
            :.|..:|..|.:|.:|....|.....:|             |.|..|.|.:.::.:|.:|:....
  Fly  1726 LYCEERFTNEISLKKHHQLAHGALTTMP-------------YVCTICKRGYRMRTALHRHMESHD 1777

  Fly   842 VAKKNPGKKYLCSLCGLESLTPNKLNIH-MRRHTGEKPFKCDLCDMRFTVHYELKVHRRKHTGER 905
            |    .|:.|.|::|.:....|::|.:| :..|...||..||.|..:|.....||.|.:.| ||.
  Fly  1778 V----EGRPYECNICRVRFPRPSQLTLHKITVHLLSKPHTCDECGKQFGTESALKTHIKFH-GEL 1837

  Fly   906 PYQCTFCDKDFARPDKLRRHVFMHND 931
            .|||..||:.|....:||:|...|::
  Fly  1838 GYQCDGCDRTFEYLKELRKHRRTHSE 1863

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10669	NP_001163728.1	zf-AD	4..81	CDD:285071
		C2H2 Zn finger	178..199	CDD:275368
		C2H2 Zn finger	216..233	CDD:275368
		C2H2 Zn finger	520..542	CDD:275368	0/21 (0%)
		C2H2 Zn finger	550..570	CDD:275368	6/19 (32%)
		C2H2 Zn finger	579..600	CDD:275368	7/20 (35%)
		C2H2 Zn finger	610..630	CDD:275368	6/19 (32%)
		C2H2 Zn finger	716..737	CDD:275368	4/20 (20%)
		C2H2 Zn finger	746..766	CDD:275368	4/30 (13%)
		C2H2 Zn finger	776..795	CDD:275368	6/18 (33%)
		C2H2 Zn finger	820..838	CDD:275368	5/17 (29%)
		C2H2 Zn finger	853..873	CDD:275368	5/20 (25%)
		zf-H2C2_2	866..889	CDD:290200	8/23 (35%)
		COG5048	877..>930	CDD:227381	21/52 (40%)
		C2H2 Zn finger	881..901	CDD:275368	7/19 (37%)
		zf-H2C2_2	893..918	CDD:290200	12/24 (50%)
		C2H2 Zn finger	909..929	CDD:275368	7/19 (37%)
mld	NP_001247289.1	zf-AD	186..255	CDD:214871
		C2H2 Zn finger	1365..1388	CDD:275368	7/66 (11%)
		C2H2 Zn finger	1396..1416	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1424..1445	CDD:275368	7/20 (35%)
		C2H2 Zn finger	1725..1746	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1756..1776	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1785..1806	CDD:275368	5/20 (25%)
		C2H2 Zn finger	1814..1834	CDD:275368	7/19 (37%)
		zf-C2H2	1839..1861	CDD:278523	9/21 (43%)
		C2H2 Zn finger	1841..1861	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1868..1888	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24376
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100