Protein Alignment CG10669 and Zfp759

DIOPT Version :10

• Sequence 1: NP_651388.1
• Gene: CG10669 / 43069
• FlyBaseID: FBgn0039329
• Length: 933
• Species: Drosophila melanogaster
• Sequence 2: XP_006517316.1
• Gene: Zfp759 / 268670
• MGIID: 2446280
• Length: 747
• Species: Mus musculus
• Alignment Length: 971
• Identity: 198/971 - (20%)
• Similarity: 308/971 - (31%)
• Gaps: 356/971 - (36%)

  Fly    18 ETPVEKYAEKTFVQLLVELTRIEVVMAQAEKF----PQWLCYACAEKLESTYDFVLQARRTHELW 78
            :.||...|.:  ||.::....:.:..:..|:.    |||..|... .||:..:.|.....:.:.:
Mouse    17 DRPVMTLANQ--VQNMLSFWDVVIYFSAEEREYLGPPQWKLYRDV-MLENYNNLVFLGLASSKPY 78

  Fly    79 LQKIGDSLNGDDEMEGTAALECLRETPIHLFEIEGVTIKTEELASTQQAPKADPLVRPRIVKRSI 143
            |.:..:.:.        ..|:...:..|.::. .|.:...:|::..::.          :..:.|
Mouse    79 LVRFLEQIQ--------EPLDVKSQVAISMYS-GGNSSTCKEVSEREKV----------LGNQQI 124

  Fly   144 VHFSDSDEDLDDVPLRQRKIAASVCGSDTTKEN----------VCELCNKVFRYVTNLYRHKQRD 198
            :|       |...|....::..|.|.|....|:          ..|.|:|.|...:.|.:||
Mouse   125 IH-------LGLKPYSCEEVGKSFCFSSLLSEHKRIHTGEKPYKYETCSKAFHVPSKLSQHK--- 179

  Fly   199 HGILGKNGEDYEEDYYKCDLCDKTYKYVMALVKHK--HKEHGSSLLSNNSGRKMPSTLAEDANPY 261
               :.:.|    |..|.|::|.|.:||...|.|||  ||           |.|          ||
Mouse   180 ---IIRTG----EKPYNCEVCAKAFKYPSRLSKHKIIHK-----------GEK----------PY 216

  Fly   262 ----------SPASISETSTNQSRTNNDSLVHSIIKAVVLSDEDGHSGEDSYYNCDQCSKSYKYI 316
                      ||:||.:              |..|          |:|| ....||.|.|:::|.
Mouse   217 KCKVCGKAFFSPSSICQ--------------HERI----------HTGE-LPCKCDVCGKAFQYP 256

  Fly   317 VSLIKHK--HKEHLDKESYKQSDDEDDRPLASTSASASAPTAKPSRINRRVDGFDFHRSEPNGAK 379
            ..|.|||  |.|.                                                   |
Mouse   257 SLLSKHKIIHTEQ---------------------------------------------------K 270

  Fly   380 EIKCMICLRRFTKLRELRNHLQNHPTDFDFEAHGEPIERIAEGFFKTAVESTAEGLKRRIFRDLR 444
            ..||.:|.........|..|.:.|.        ||
Mouse   271 PYKCEVCGNFLRSRSSLHEHKRMHA--------GE------------------------------ 297

  Fly   445 MGVYGRYYSITNQARYEMTLDSSDTDSDGDGDDNVVIRRSYSCELCDSPEARWPRKYLLHQHHQK 509
                                                  :.|.||:| .....:|.:.   ..|:.
Mouse   298 --------------------------------------KPYKCEVC-GKAFEYPSRL---SKHKN 320

  Fly   510 EHTWLDAPHVCQRCDSRFLNLQLLKHHTSQLCQNTLKRFMCDKCPQRFFWRRNLRAHLVEHKCKQ 574
            .||. :.|:.|:.|...|.:...|:.|..  .....|.:.|:.|.:.|.:...|..|...| ..:
Mouse   321 IHTG-ETPYKCKVCGKAFRSPSSLRVHKG--IHREDKPYKCEVCGKAFRYSSVLSDHKNIH-TGE 381

  Fly   575 ESYPCDQCSRSFQDKSAVTKHKLMMHRDSNMELLPCRWCTRTFYRPALLYKHLQRHGFTGQDLPL 639
            ..|.|..|.::|:..|::..|| ..||..  :...|..|.:.|:.|::|..|...|
Mouse   382 TPYKCKVCGKAFRSPSSLRVHK-GTHRGG--KPYKCEVCGKAFHYPSILSNHKNIH--------- 434

  Fly   640 AETLLADASKPAGPKSVQCKICDIQFVSVADLRRHISMQGHSDQPSAYMISTATGFELLLDDTDD 704
                       .|....:||:|...|              ||  ||:.::...|..|
Mouse   435 -----------TGETPYKCKVCGKAF--------------HS--PSSLILHKGTHRE-------- 464

  Fly   705 SDEETSGRTYSCDLCDLNFRRRREISEH---------------------------QYSLHSFDKL 742
                  .:.|.|::|...||....:|.|                           |..:|:.:|
Mouse   465 ------DKPYKCEVCGKAFRYPSILSNHKKIHREQKPSKCKVGRKVFWSPSSLPEQKRIHTREK- 522

  Fly   743 PHNCEHC--IFKTVDKNMLHQHLRTQCMNTEKKFACMRCGYKFMWEENLAQHLSTQHSKQPAVPE 805
            |:|||.|  .||...:.:.|:.:.|:    ||::.|..||..|....:|.||......:.|.
Mouse   523 PYNCEICGKAFKYPSRLLKHKIIHTR----EKQYKCKVCGNAFCTPSSLWQHKRIHTGELPC--- 580

  Fly   806 QQPPLRRKRRFRYQCPHCWRSFVVQPSLDKHIRDMHVAKKNPGKKYLCSLCGLESLTPNKLNIHM 870
                         :|..|.::|.....|.|| :..|..:    |.|.|.:||....:.:.|:.|.
Mouse   581 -------------KCDVCGKTFRFPSLLLKH-KISHTDQ----KPYKCKICGNFLRSQSSLHEHK 627

  Fly   871 RRHTGEKPFKCDLCDMRFTVHYELKVHRRKHTGERPYQCTFCDKDFARPDKLRRHVFMHND 931
            |.|.||||:||::|...|.....|..|...||||.||:|..|.|.|..|..||.|..:|.:
Mouse   628 RMHAGEKPYKCEICGKAFEYPSRLSKHNNIHTGETPYKCKVCGKAFRSPSSLRVHKGIHRE 688

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10669	NP_651388.1	zf-AD	4..80	CDD:462262	13/65 (20%)
		C2H2 Zn finger	178..199	CDD:275368	7/20 (35%)
		C2H2 Zn finger	216..233	CDD:275368	7/16 (44%)
		C2H2 Zn finger	520..542	CDD:275368	5/21 (24%)
		C2H2 Zn finger	550..570	CDD:275368	5/19 (26%)
		C2H2 Zn finger	579..600	CDD:275368	6/20 (30%)
		C2H2 Zn finger	610..630	CDD:275368	6/19 (32%)
		C2H2 Zn finger	716..737	CDD:275368	7/47 (15%)
		C2H2 Zn finger	746..766	CDD:275368	6/21 (29%)
		C2H2 Zn finger	776..795	CDD:275368	7/18 (39%)
		C2H2 Zn finger	820..838	CDD:275368	6/17 (35%)
		C2H2 Zn finger	853..873	CDD:275368	6/19 (32%)
		zf-H2C2_2	866..889	CDD:463886	11/22 (50%)
		C2H2 Zn finger	881..901	CDD:275368	5/19 (26%)
		zf-H2C2_2	893..918	CDD:463886	12/24 (50%)
		C2H2 Zn finger	909..929	CDD:275368	8/19 (42%)
Zfp759	XP_006517316.1	KRAB	31..89	CDD:214630	9/66 (14%)
		C2H2 Zn finger	134..154	CDD:275368	4/19 (21%)
		COG5048	158..547	CDD:227381	120/633 (19%)
		C2H2 Zn finger	165..182	CDD:275368	6/22 (27%)
		C2H2 Zn finger	190..210	CDD:275368	9/19 (47%)
		C2H2 Zn finger	218..238	CDD:275368	6/43 (14%)
		C2H2 Zn finger	246..266	CDD:275368	9/19 (47%)
		C2H2 Zn finger	274..294	CDD:275368	4/19 (21%)
		C2H2 Zn finger	302..322	CDD:275368	5/23 (22%)
		C2H2 Zn finger	330..350	CDD:275368	5/21 (24%)
		C2H2 Zn finger	358..378	CDD:275368	5/19 (26%)
		C2H2 Zn finger	386..406	CDD:275368	6/20 (30%)
		COG5048	410..>742	CDD:227381	88/355 (25%)
		C2H2 Zn finger	414..434	CDD:275368	6/19 (32%)
		C2H2 Zn finger	442..462	CDD:275368	8/35 (23%)
		C2H2 Zn finger	470..490	CDD:275368	6/19 (32%)
		C2H2 Zn finger	498..514	CDD:275370	0/15 (0%)
		C2H2 Zn finger	526..546	CDD:275368	6/19 (32%)
		C2H2 Zn finger	554..574	CDD:275368	7/19 (37%)
		C2H2 Zn finger	582..602	CDD:275368	6/20 (30%)
		C2H2 Zn finger	610..630	CDD:275368	6/19 (32%)
		C2H2 Zn finger	638..658	CDD:275368	5/19 (26%)
		C2H2 Zn finger	666..686	CDD:275368	8/19 (42%)
		C2H2 Zn finger	694..714	CDD:275368
		C2H2 Zn finger	722..742	CDD:275368