DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG10669 and ZNF521

DIOPT Version :10

Sequence 1:NP_651388.1 Gene:CG10669 / 43069 FlyBaseID:FBgn0039329 Length:933 Species:Drosophila melanogaster
Sequence 2:NP_056276.1 Gene:ZNF521 / 25925 HGNCID:24605 Length:1311 Species:Homo sapiens


Alignment Length:1082 Identity:196/1082 - (18%)
Similarity:333/1082 - (30%) Gaps:424/1082 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly   135 RPRIVKRSIVHFSDSDEDLDDVPLRQRKIAASVCGSDTTKENV--CELCNKVFRYVTNLYRHK-- 195
            :||.:|.......|..||.:.:..::|    ...|.:...|.|  |:.|.:||..::::..||  
Human     8 KPRSLKDPNCKLEDKTEDGEALDCKKR----PEDGEELEDEAVHSCDSCLQVFESLSDITEHKIN 68

  Fly   196 ------------------------QRD-----HGILGKNGEDYEEDY------YKCDLCDKTYKY 225
                                    .:|     ||    .|.|:.|:.      |.|..|||::..
Human    69 QCQLTDGVDVEDDPTCSWPASSPSSKDQTSPSHG----EGCDFGEEEGGPGLPYPCQFCDKSFSR 129

  Fly   226 VMALVKHKHKEHGSSLLSNNSGRKMPSTLAEDANPYSPASISET-STNQSRTNNDSLVHSIIKAV 289
             ::.:||..:.|...|                  |:.....|.. ...:||..:..|        
Human   130 -LSYLKHHEQSHSDKL------------------PFKCTYCSRLFKHKRSRDRHIKL-------- 167

  Fly   290 VLSDEDGHSGEDSYYNCDQC-------------------SKSYKYIV---------SLIKHKHKE 326
                   |:| |..|:|.:|                   :|.||..:         ||..|....
Human   168 -------HTG-DKKYHCSECDAAFSRSDHLKIHLKTHTSNKPYKCAICRRGFLSSSSLHGHMQVH 224

  Fly   327 HLDKESYKQSDDEDDRPLASTSASASAPTAKPSRINRRVDGFDF------HRSE------PN--- 376
            ..:|:..:.....:|..:..|           .:.::..:||||      |.:|      ||   
Human   225 ERNKDGSQSGSRMEDWKMKDT-----------QKCSQCEEGFDFPEDLQKHIAECHPECSPNEDR 278

  Fly   377 ---------------------------GAKEIKCMICLRRFTKLRELRNHLQNH--PTDFDFEAH 412
                                       |.|:..|.||...|..:.||.:|:.:|  |...:   |
Human   279 AALQCVYCHELFVEETSLMNHMEQVHSGEKKNSCSICSESFHTVEELYSHMDSHQQPESCN---H 340

  Fly   413 GEPIERIAEGFFKTAVEST----------------------AEGLKRRIFRDLRMGVYGRYYSIT 455
            ......:..|:  |:|.||                      :.|.||                  
Human   341 SNSPSLVTVGY--TSVSSTTPDSNLSVDSSTMVEAAPPIPKSRGRKR------------------ 385

  Fly   456 NQARYEMTLDSSDTDSDGDGDDNVVIRRSYSCELCDSPEARWPRKYLLHQHHQKEHTWLDAP--- 517
                      ::....|..|..:...:.:|||..|:  :..:....:|..|.:..|  ||.|   
Human   386 ----------AAQQTPDMTGPSSKQAKVTYSCIYCN--KQLFSSLAVLQIHLKTMH--LDKPEQA 436

  Fly   518 HVCQRCDSRFLNLQLLKHHTSQ--------LCQNTLKR--FMCDKCPQRFFWRRNLRAHLVEHKC 572
            |:||.|.....:|..|..|..|        |..:.:..  :.|:.|.:.......|:.|:   :|
Human   437 HICQYCLEVLPSLYNLNEHLKQVHEAQDPGLIVSAMPAIVYQCNFCSEVVNDLNTLQEHI---RC 498

  Fly   573 K----------QESYPCDQCSRSFQDKSAVTKHKLMMHRDSN----------------MELLPCR 611
            .          ..::.|..|...|...|::.:|...:|.|.:                :|:..|.
Human   499 SHGFANPAAKDSNAFFCPHCYMGFLTDSSLEEHIRQVHCDLSGSRFGSPVLGTPKEPVVEVYSCS 563

  Fly   612 WCTRT--FYRPALLYKHLQRHGFTGQDLPLAETLLADASK-----PAGPKSVQ------------ 657
            :||.:  |.....|.||::.:   .:::|||...:.:..|     |..|.:::            
Human   564 YCTNSPIFNSVLKLNKHIKEN---HKNIPLALNYIHNGKKSRALSPLSPVAIEQTSLKMMQAVGG 625

  Fly   658 ----------CKICDIQFVSVADLRRHISM------------QGHSDQPSAYMISTATGFELLLD 700
                      |..|..::.|:...:.|:..            |.:.:.|:...:........::.
Human   626 APARPTGEYICNQCGAKYTSLDSFQTHLKTHLDTVLPKLTCPQCNKEFPNQESLLKHVTIHFMIT 690

  Fly   701 DTDDSDEETSGRTYSCDLCDLNFRRRREISEHQYSLHSF-------------------------- 739
            .|          .|.|:.||..|....::.:|...:|:|                          
Human   691 ST----------YYICESCDKQFTSVDDLQKHLLDMHTFVFFRCTLCQEVFDSKVSIQLHLAVKH 745

  Fly   740 --DKLPHNCEHCIF-----KTVDKNMLHQHLRTQCMNTEKKFACMRCGYKFMWEENLAQHLSTQH 797
              :|..:.|..|.:     ..:..::.|.||.    |..|...|:.||..|..|..|..|::| |
Human   746 SNEKKVYRCTSCNWDFRNETDLQLHVKHNHLE----NQGKVHKCIFCGESFGTEVELQCHITT-H 805

  Fly   798 SKQPAVPEQQPPLRRKRRFRYQCPHCWRSFVVQPSLDKHIRDMHVA--KKNPGKKYLCSLCG--- 857
            ||                 :|.|..|.::|.....|:||:|:.|..  .|.|.       ||   
Human   806 SK-----------------KYNCKFCSKAFHAIILLEKHLREKHCVFETKTPN-------CGTNG 846

  Fly   858 -----------LESLTPNKLNIHMRRH--------TGEKPFKCDLCDMRFTVHYELKVHRRKHTG 903
                       |::|..|....| ..|        |.|..:.||:|...:|:...|:.|:.:...
Human   847 ASEQVQKEEVELQTLLTNSQESH-NSHDGSEEDVDTSEPMYGCDICGAAYTMETLLQNHQLRDHN 910

  Fly   904 ERP----------------YQCTFCDKDFARPDKLRRHVFMH 929
            .||                |:|..|.:.|...:.||.|:..|
Human   911 IRPGESAIVKKKAELIKGNYKCNVCSRTFFSENGLREHMQTH 952

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG10669NP_651388.1 zf-AD 4..80 CDD:462262
C2H2 Zn finger 178..199 CDD:275368 7/51 (14%)
C2H2 Zn finger 216..233 CDD:275368 5/16 (31%)
C2H2 Zn finger 520..542 CDD:275368 8/29 (28%)
C2H2 Zn finger 550..570 CDD:275368 4/19 (21%)
C2H2 Zn finger 579..600 CDD:275368 5/20 (25%)
C2H2 Zn finger 610..630 CDD:275368 7/21 (33%)
C2H2 Zn finger 716..737 CDD:275368 5/20 (25%)
C2H2 Zn finger 746..766 CDD:275368 5/24 (21%)
C2H2 Zn finger 776..795 CDD:275368 7/18 (39%)
C2H2 Zn finger 820..838 CDD:275368 6/17 (35%)
C2H2 Zn finger 853..873 CDD:275368 6/33 (18%)
zf-H2C2_2 866..889 CDD:463886 7/30 (23%)
C2H2 Zn finger 881..901 CDD:275368 6/19 (32%)
zf-H2C2_2 893..918 CDD:463886 8/40 (20%)
C2H2 Zn finger 909..929 CDD:275368 6/19 (32%)
ZNF521NP_056276.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..37 7/32 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 81..108 5/30 (17%)
C2H2 Zn finger 120..140 CDD:275368 6/20 (30%)
COG5048 128..>216 CDD:227381 18/122 (15%)
C2H2 Zn finger 148..168 CDD:275368 4/34 (12%)
zf-H2C2_2 162..185 CDD:463886 7/38 (18%)
C2H2 Zn finger 176..196 CDD:275368 2/19 (11%)
C2H2 Zn finger 204..224 CDD:275368 3/19 (16%)
C2H2 Zn finger 248..265 CDD:275368 4/16 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 349..397 10/77 (13%)
C2H2 Zn finger 407..428 CDD:275368 4/22 (18%)
C2H2 Zn finger 439..460 CDD:275368 7/20 (35%)
C2H2 Zn finger 479..498 CDD:275368 4/21 (19%)
C2H2 Zn finger 636..656 CDD:275368 4/19 (21%)
C2H2 Zn finger 666..686 CDD:275368 2/19 (11%)
C2H2 Zn finger 696..713 CDD:275368 4/16 (25%)
C2H2 Zn finger 724..745 CDD:275368 0/20 (0%)
C2H2 Zn finger 754..774 CDD:275368 2/19 (11%)
C2H2 Zn finger 785..805 CDD:275368 8/20 (40%)
C2H2 Zn finger 811..829 CDD:275368 6/17 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 863..882 3/19 (16%)
C2H2 Zn finger 888..909 CDD:275368 6/20 (30%)
C2H2 Zn finger 932..952 CDD:275368 6/19 (32%)
C2H2 Zn finger 961..981 CDD:275368
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1168..1188
C2H2 Zn finger 1227..1247 CDD:275368
C2H2 Zn finger 1258..1279 CDD:275368
C2H2 Zn finger 1288..1307 CDD:275368
Blue background indicates that the domain is not in the aligned region.

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