DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG10669 and ZNF473

DIOPT Version :10

Sequence 1:NP_651388.1 Gene:CG10669 / 43069 FlyBaseID:FBgn0039329 Length:933 Species:Drosophila melanogaster
Sequence 2:NP_056243.1 Gene:ZNF473 / 25888 HGNCID:23239 Length:871 Species:Homo sapiens


Alignment Length:853 Identity:194/853 - (22%)
Similarity:309/853 - (36%) Gaps:245/853 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   255 AEDANPYSPASISETSTNQSRTNNDSLVHSIIKAVVLSDEDGHSGE-------DSYYNC---DQC 309
            :||..|.:..|...||.:.:.|.|..|:....       |:|.|.|       |.::|.   :.|
Human    59 SEDLEPLAGGSPEATSPDVTETKNSPLMEDFF-------EEGFSQEIIEMLSKDGFWNSNFGEAC 116

  Fly   310 SKSYKYIVSLIKHKHKEHLDKESYKQSD-------------DEDDRPLASTSA----------SA 351
            .:. .::.||:.       |.||..:||             .|..|.|:..|.          :.
Human   117 IED-TWLDSLLG-------DPESLLRSDIATNGESPTECKSHELKRGLSPVSTVSTGEDSMVHNV 173

  Fly   352 SAPTAKPSRINR-RVDGFDF--HRSEPN---GAKEIKCMICLRRFTKLRELRNHLQNH----PTD 406
            |..|..|::... |.:.|.:  |..:.:   |.|..:|..|.:.|:....|..|...|    || 
Human   174 SEKTLTPAKSKEYRGEFFSYSDHSQQDSVQEGEKPYQCSECGKSFSGSYRLTQHWITHTREKPT- 237

  Fly   407 FDFEAHGEPIERIAEGFFKTAVES----TAEGLKRRIFRDLRMGVYGRYYSITNQARY------- 460
                .|.|    ..:||.:.|..|    |..|.|..:..:     ||..:|   |:.|       
Human   238 ----VHQE----CEQGFDRNASLSVYPKTHTGYKFYVCNE-----YGTTFS---QSTYLWHQKTH 286

  Fly   461 --EMTLDSSDTD-------SDGDGDDNVVIRRSYSCELCDSPEARWPRKYLLH-QHHQKEHTWLD 515
              |....|.|:|       ..|:........:||:|..|.....|     :.| ..|||.||  .
Human   287 TGEKPCKSQDSDHPPSHDTQPGEHQKTHTDSKSYNCNECGKAFTR-----IFHLTRHQKIHT--R 344

  Fly   516 APHVCQRCDSRF-LNLQLLKHHTSQLCQNTLKRFMCDKCPQRFFWRRNLRAHLVEHK---CKQES 576
            ..:.|.:|.:.| |...|::|..:...:.|.:   |.:| .:.|...:|   |:||:   ..:|.
Human   345 KRYECSKCQATFNLRKHLIQHQKTHAAKTTSE---CQEC-GKIFRHSSL---LIEHQALHAGEEP 402

  Fly   577 YPCDQCSRSFQDKSAVTKHK-----------------------LMMHRDSNMELLP--CRWCTRT 616
            |.|::..:||:..|.:..|:                       |..||..:....|  |:.|.|:
Human   403 YKCNERGKSFRHNSTLKIHQRVHSGEKPYKCSECGKAFHRHTHLNEHRRIHTGYRPHKCQECVRS 467

  Fly   617 FYRPALLYKHLQRHGFTGQDLPLAE---------------TLLADASKPAGPKS-VQCKICDIQF 665
            |.||:    ||.||    |.:..||               ..|....|....|: .:|:.|..:|
Human   468 FSRPS----HLMRH----QAIHTAEKPYSCAECKETFSDNNRLVQHQKMHTVKTPYECQECGERF 524

  Fly   666 VSVADLRRHISMQGHSDQPSAYMISTATGFELLLDDTDDSDEETSGRTYSCDLCDLNFRRRREIS 730
            :..:.|:.|.|:  |:.:...:.:|..     :||...:..|    :.:.|:.|:..|...:.::
Human   525 ICGSTLKCHESV--HAREKQGFFVSGK-----ILDQNPEQKE----KCFKCNKCEKTFSCSKYLT 578

  Fly   731 EHQYSLHSFDKLPHNCEHC------IFKTVDKNMLHQHLR------------------------- 764
            :|: .:|:....|..|:.|      ..:.:....:|..:|                         
Human   579 QHE-RIHTRGVKPFECDQCGKAFGQSTRLIHHQRIHSRVRLYKWGEQGKAISSASLIKLQSFHTK 642

  Fly   765 ------TQCMNT----------------EKKFACMRCGYKFMWEENLAQHLSTQHSKQPAVP--- 804
                  .:|..|                |..|.|.:|...|.....|.||..|...|:|.|.   
Human   643 EHPFKCNECGKTFSHSAHLSKHQLIHAGENPFKCSKCDRVFTQRNYLVQHERTHARKKPLVCNEC 707

  Fly   805 ----EQQPPLRRKRRFR-----YQCPHCWRSFVVQPSLDKHIRDMHVAKKNPGKKYLCSLCGLES 860
                .|...|.:.:|..     |.|.:|.::|.:...|.:|.| :|..:    |.|:|..||...
Human   708 GKTFRQSSCLSKHQRIHSGEKPYVCDYCGKAFGLSAELVRHQR-IHTGE----KPYVCQECGKAF 767

  Fly   861 LTPNKLNIHMRRHTGEKPFKCDLCDMRFTVHYELKVHRRKHTGERPYQCTFCDKDFARPDKLRRH 925
            ...:.|:||.|.||||||::|..|...|.....|..|:|.||||:||.|..|.|.|.....|.:|
Human   768 TQSSCLSIHRRVHTGEKPYRCGECGKAFAQKANLTQHQRIHTGEKPYSCNVCGKAFVLSAHLNQH 832

  Fly   926 VFMHNDKS 933
            :.:|..::
Human   833 LRVHTQET 840

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG10669NP_651388.1 zf-AD 4..80 CDD:462262
C2H2 Zn finger 178..199 CDD:275368
C2H2 Zn finger 216..233 CDD:275368
C2H2 Zn finger 520..542 CDD:275368 6/22 (27%)
C2H2 Zn finger 550..570 CDD:275368 5/19 (26%)
C2H2 Zn finger 579..600 CDD:275368 6/43 (14%)
C2H2 Zn finger 610..630 CDD:275368 8/19 (42%)
C2H2 Zn finger 716..737 CDD:275368 4/20 (20%)
C2H2 Zn finger 746..766 CDD:275368 4/56 (7%)
C2H2 Zn finger 776..795 CDD:275368 6/18 (33%)
C2H2 Zn finger 820..838 CDD:275368 5/17 (29%)
C2H2 Zn finger 853..873 CDD:275368 7/19 (37%)
zf-H2C2_2 866..889 CDD:463886 12/22 (55%)
C2H2 Zn finger 881..901 CDD:275368 6/19 (32%)
zf-H2C2_2 893..918 CDD:463886 13/24 (54%)
C2H2 Zn finger 909..929 CDD:275368 6/19 (32%)
ZNF473NP_056243.1 KRAB_A-box 6..45 CDD:143639
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 47..81 6/21 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 140..164 4/23 (17%)
COG5048 207..614 CDD:227381 99/457 (22%)
C2H2 Zn finger 211..231 CDD:275368 5/19 (26%)
C2H2 Zn finger 239..259 CDD:275368 6/23 (26%)
C2H2 Zn finger 267..286 CDD:275368 5/26 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 290..318 4/27 (15%)
Interaction with SLBP/pre-mRNA complex 312..552 60/268 (22%)
C2H2 Zn finger 322..342 CDD:275368 7/24 (29%)
C2H2 Zn finger 349..369 CDD:275368 6/19 (32%)
C2H2 Zn finger 377..397 CDD:275368 7/23 (30%)
C2H2 Zn finger 405..425 CDD:275368 5/19 (26%)
C2H2 Zn finger 433..453 CDD:275368 3/19 (16%)
COG5048 457..860 CDD:227381 97/409 (24%)
C2H2 Zn finger 461..481 CDD:275368 11/27 (41%)
C2H2 Zn finger 489..509 CDD:275368 2/19 (11%)
C2H2 Zn finger 517..537 CDD:275368 6/21 (29%)
C2H2 Zn finger 564..584 CDD:275368 4/20 (20%)
C2H2 Zn finger 593..613 CDD:275368 2/19 (11%)
C2H2 Zn finger 648..668 CDD:275368 2/19 (11%)
C2H2 Zn finger 676..696 CDD:275368 6/19 (32%)
C2H2 Zn finger 704..724 CDD:275368 3/19 (16%)
C2H2 Zn finger 732..752 CDD:275368 6/20 (30%)
C2H2 Zn finger 760..780 CDD:275368 7/19 (37%)
C2H2 Zn finger 788..808 CDD:275368 6/19 (32%)
C2H2 Zn finger 816..836 CDD:275368 6/19 (32%)
C2H2 Zn finger 844..864 CDD:275368
Blue background indicates that the domain is not in the aligned region.

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