DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10669 and Zfp420

DIOPT Version :9

Sequence 1:	NP_001163728.1	Gene:	CG10669 / 43069	FlyBaseID:	FBgn0039329	Length:	933	Species:	Drosophila melanogaster
Sequence 2:	NP_001351547.1	Gene:	Zfp420 / 233058	MGIID:	2444666	Length:	578	Species:	Mus musculus

Alignment Length:	769	Identity:	175/769 - (22%)
Similarity:	276/769 - (35%)	Gaps:	243/769 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   169 GSDTTKENVCELCNKVFRYVTNLYRHKQRDHGILGKNGEDYEEDYYKCDLCDKTYKYVMALVKHK 233
            |..|.|...||.|.|.||..::|.:|:....|          |..|:|..|.|.:
Mouse    22 GYSTEKPYKCEECGKAFRRASHLSQHQSIHTG----------EKPYECKQCGKAF---------- 66

  Fly   234 HKEHGSSLLSNNSGRKMPSTLAEDANPYSPASISETSTNQSRTNNDSLVHSIIKAVVLSDEDGHS 298
                                                    ||.:..||...:           |:
Mouse    67 ----------------------------------------SRDSQLSLHQRL-----------HT 80

  Fly   299 GEDSYYNCDQCSKSYKYIVSLIKHKHKEHLDKESYKQSDDEDDRPLASTSASASAPTAKPSRINR 363
            ||.. |.|.:|.|::.....||.| |:.|..::.||             ..:......:.|:::|
Mouse    81 GEKP-YTCKECGKAFTQSSQLILH-HRIHTGEKPYK-------------CEACGKAFIRSSQLSR 130

  Fly   364 RVDGFDFHRSEPNGAKEIKCMICLRRFTKLRELRNHLQNHPTDFDFEAHGEPIERIAEGFFKTAV 428
                   |:....|.|..:|..|.:.||:..:|..|.:.|.        ||.:....|
Mouse   131 -------HQKVHTGEKPFECKECGKAFTQNSQLTLHQRLHT--------GEKLYDCKE------- 173

  Fly   429 ESTAEGLKRRIFRDL-RMGVYGRYYSITNQARYEMTLDSSDTDSDGDGDDNVVIRRSYSCE---- 488
                   .|::|..| ::.::.|.::                     |:      :.|.|.
Mouse   174 -------CRKVFTQLSQLILHRRIHT---------------------GE------KPYECNECGK 204

  Fly   489 --LCDSPEARWPRKYLLHQHHQKEHTWLDAPHVCQRCDSRFLNLQLLKHHTSQLCQNTLKRFMCD 551
              :|.|..::          |:|.|.. :.|:.|:.|...|:...||..|  |......|.:.||
Mouse   205 AFICGSQLSQ----------HRKIHNG-EKPYECKECGKAFIRGSLLMQH--QRIHTGEKPYKCD 256

  Fly   552 KCPQRFFWRRNLRAHLVEHKCKQESYPCDQCSRSFQDKSAVTKHKLMMHRDSNMELLPCRWCTRT 616
            :|.:.|.....|..|...| ..::.|.|.:|.::|...|.:|:|:.:...:...:   |:.|.:.
Mouse   257 ECGKAFIRGSQLTQHQRVH-TNEKPYECKECGKTFSHGSQLTQHQRIHTGEKPYQ---CKECGKA 317

  Fly   617 FYRPALLYKHLQRHGFTGQDLPLAETLLADASKPAGPKSVQCKICDIQFVSVADLRRHISMQGHS 681
            |.|.:||.:|.:.|                    .|.|..:||.|...|...::|.:|..:
Mouse   318 FNRGSLLTRHQRIH--------------------TGEKPYKCKECGKNFSRGSELTQHERI---- 358

  Fly   682 DQPSAYMISTATGFELLLDDTDDSDEETSGRTYSCDLCDLNFRRRREISEHQYSLHSFDKLPHNC 746
                                      .|..:.|.|..|..:|.|..::::|| .:|:.:| |:.|
Mouse   359 --------------------------HTGEKPYECKECGKSFIRGSQLTQHQ-RIHTGEK-PYEC 395

  Fly   747 EHCIFKTVDKNMLHQHLRTQCMNT-EKKFACMRCGYKFMWEENLAQHLSTQHSKQPAVPEQQPPL 810
            :.|.......:.|.||.|   ::| ||.:.|..||..|.....|.||......::|
Mouse   396 KECRMAFTQSSHLSQHQR---LHTGEKPYVCSECGKAFARGLLLIQHQRIHTGEKP--------- 448

  Fly   811 RRKRRFRYQCPHCWRSFVVQPSLDKHIRDMHVAKKNPGKKYLCSLCGLESLTPNKLNIHMRRHTG 875
                   |||..|.::|:....|.:|.| .|..:    |.|.|..||......::|.:|.|.|||
Mouse   449 -------YQCRECGKAFIRSSQLTQHQR-THTGE----KPYECRECGKAFGHGSQLTLHQRVHTG 501

  Fly   876 EKPFKCDLCDMRFTVHYELKVHRRKHTGERPYQCTFCDKDFARPDKLRRHVFMH 929
            |||::|..|...||....|..|:|.||||:||||..|:|.|.|..:|.||..:|
Mouse   502 EKPYECKECRKAFTQSSHLSRHQRVHTGEKPYQCKECEKAFTRESQLMRHQRIH 555

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10669	NP_001163728.1	zf-AD	4..81	CDD:285071
		C2H2 Zn finger	178..199	CDD:275368	8/20 (40%)
		C2H2 Zn finger	216..233	CDD:275368	3/16 (19%)
		C2H2 Zn finger	520..542	CDD:275368	7/21 (33%)
		C2H2 Zn finger	550..570	CDD:275368	6/19 (32%)
		C2H2 Zn finger	579..600	CDD:275368	6/20 (30%)
		C2H2 Zn finger	610..630	CDD:275368	7/19 (37%)
		C2H2 Zn finger	716..737	CDD:275368	6/20 (30%)
		C2H2 Zn finger	746..766	CDD:275368	6/19 (32%)
		C2H2 Zn finger	776..795	CDD:275368	7/18 (39%)
		C2H2 Zn finger	820..838	CDD:275368	5/17 (29%)
		C2H2 Zn finger	853..873	CDD:275368	6/19 (32%)
		zf-H2C2_2	866..889	CDD:290200	11/22 (50%)
		COG5048	877..>930	CDD:227381	25/53 (47%)
		C2H2 Zn finger	881..901	CDD:275368	7/19 (37%)
		zf-H2C2_2	893..918	CDD:290200	14/24 (58%)
		C2H2 Zn finger	909..929	CDD:275368	8/19 (42%)
Zfp420	NP_001351547.1	COG5048	23..462	CDD:227381	133/668 (20%)
		C2H2 Zn finger	31..51	CDD:275368	8/19 (42%)
		C2H2 Zn finger	59..79	CDD:275368	7/80 (9%)
		C2H2 Zn finger	87..107	CDD:275368	7/20 (35%)
		C2H2 Zn finger	115..135	CDD:275368	3/26 (12%)
		C2H2 Zn finger	143..163	CDD:275368	6/19 (32%)
		C2H2 Zn finger	171..191	CDD:275368	5/33 (15%)
		C2H2 Zn finger	199..219	CDD:275368	5/29 (17%)
		C2H2 Zn finger	227..247	CDD:275368	7/21 (33%)
		C2H2 Zn finger	255..275	CDD:275368	6/19 (32%)
		C2H2 Zn finger	283..303	CDD:275368	6/19 (32%)
		C2H2 Zn finger	311..331	CDD:275368	7/19 (37%)
		C2H2 Zn finger	339..359	CDD:275368	6/49 (12%)
		C2H2 Zn finger	367..387	CDD:275368	6/20 (30%)
		C2H2 Zn finger	395..415	CDD:275368	6/22 (27%)
		C2H2 Zn finger	423..443	CDD:275368	7/19 (37%)
		C2H2 Zn finger	451..471	CDD:275368	6/20 (30%)
		zf-H2C2_2	464..488	CDD:372612	9/28 (32%)
		C2H2 Zn finger	479..499	CDD:275368	6/19 (32%)
		zf-H2C2_2	492..516	CDD:372612	12/23 (52%)
		C2H2 Zn finger	507..527	CDD:275368	7/19 (37%)
		zf-H2C2_2	519..544	CDD:372612	14/24 (58%)
		C2H2 Zn finger	535..555	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833385
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930