DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10669 and Zfp52

DIOPT Version :9

Sequence 1:	NP_001163728.1	Gene:	CG10669 / 43069	FlyBaseID:	FBgn0039329	Length:	933	Species:	Drosophila melanogaster
Sequence 2:	NP_653098.2	Gene:	Zfp52 / 22710	MGIID:	99199	Length:	724	Species:	Mus musculus

Alignment Length:	890	Identity:	212/890 - (23%)
Similarity:	317/890 - (35%)	Gaps:	264/890 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 ECLRETPIHLFEIEGVTIKTEELASTQQAPKADPLVRPRIVKRSIVHFSDSDEDLDDVPLRQRKI 163
            |||......|: |:.:......|.|.:.....|.:.:|...::.....::.:|.|.:
Mouse    28 ECLDSAQRALY-IDVMVENYSNLVSVENYCICDTVHQPVRTEKESCPCNELNEMLHE-------- 83

  Fly   164 AASVCG----SDTTK-ENVCELCNKVFRYV--TNLYRHKQRDHGILGKNGEDYEEDYYKCDLCDK 221
             .|.|.    ||||: .|....||:....|  :|..|||....|         |||..:...|:|
Mouse    84 -PSNCALYNRSDTTEASNNYRCCNEKDASVDSSNADRHKSMHIG---------EEDTCQSKDCEK 138

  Fly   222 TYKYVMAL----------VKHK---HKEHGSSLLSNNSGRKMPSTLAEDANPYSPASISE-TSTN 272
            ::.....:          .:||   |.:|.|||.|     .|..|:..:..||......: .||.
Mouse   139 SFNLCSNIRQYQRLNTEKKEHKQDEHDDHFSSLYS-----LMQETVDMEEKPYQCGHCRKYFSTT 198

  Fly   273 QSRTNNDSLVHSIIKAVVLSDEDGHSGEDSYYNCDQCSKSYKYIVSLIKHKHKEHLDKESYKQSD 337
            .|.:     :|..|          |:||.. |.|:.|.||:....|| |.....|..|:.||..
Mouse   199 SSLS-----IHQRI----------HTGEKP-YKCNICGKSFNQWSSL-KTDQTLHTAKKPYKCK- 245

  Fly   338 DEDDRPLASTSASASAPTAKPSRINRRVDGFDFHRSEPNGAKEIKCMICLRRFTKLRELRNHLQN 402
             |..:.|...||..|                  |:....|.|..||..|.|.|.....||.|.:.
Mouse   246 -EGGKLLVQLSALKS------------------HQRRHTGEKPYKCQQCDRSFAHCASLRWHQKI 291

  Fly   403 HPTDFDFEAHGEPIERIAEGFFKTAVESTAE--GLKRRIFRDLRMGVYGRYYSITNQARYEMTLD 465
            |..:..:|.             |...:|..|  .|||          :.|.::.....|||: .|
Mouse   292 HSPEIHYEC-------------KECGKSCFELSHLKR----------HCRIHTAEKPYRYEV-CD 332

  Fly   466 SSDTDSD-----------------GDGDDNVVI-------------RRSYSCELCDSPEARWPRK 500
            :|.|.:.                 .:.|.::..             :|.|.|..||    ::..|
Mouse   333 TSITVNSTLKTHHKIHTREKPYRYRECDKSITKCSYLRTYQRVHTGKRPYRCTECD----KFFTK 393

  Fly   501 YLLHQHHQKEHTWLDAPHVCQRCDSRFLNLQLL----KHHTSQLCQNTLKRFMCDKCPQRFFWRR 561
            :...:.|||.||. :.|..|:.||..||.:..:    |.|..:      :|:.|.:|.:.|.|..
Mouse   394 HSNLRQHQKIHTG-EKPPKCKDCDKSFLRISSVRIRQKIHAGE------RRYRCKECGRSFTWFS 451

  Fly   562 NLRAHLVEHKCKQESYPCDQCSRSFQDKSAVTKHKLMMHRDSNMELLPCRWCTRTFYRPALLYKH 626
            |||.|...| ..:..|.|.:|.:||.
Mouse   452 NLRVHQRVH-TGERPYRCKECGKSFT--------------------------------------- 476

  Fly   627 LQRHGFTGQDLPLAETLLADASKPAGPKSVQCKICDIQFVSVADLRRHISMQGHSDQPSAYMIST 691
                  ||.:|.:.:.:      ..|.|..:||.|||.|:.:::||.|..:
Mouse   477 ------TGSNLRVHQKI------HTGEKPYKCKDCDISFLWISNLRTHQKI-------------- 515

  Fly   692 ATGFELLLDDTDDSDEETSGRTYSCDLCDLNFRRRREISEHQYSLHSFDKLPHNCEHC--IFKTV 754
                            .|..:.|.|..|:.:|.|...:.:|| .:|:.:|| :.|:.|  .|..:
Mouse   516 ----------------HTGEKPYKCQECNKSFTRCSYLRDHQ-KIHTGEKL-YKCKDCDISFMWI 562

  Fly   755 DKNMLHQHLRTQCMNTEKKFACMRCGYKFMWEENLAQHLSTQHSKQPAVPEQQPPLRRKRRFRYQ 819
            .....||.:.|    .||.:.|..|...|.....|..|......::|                |:
Mouse   563 SSLRRHQKIHT----GEKPYKCRGCEKSFTQCSTLRDHQKIHTGEKP----------------YK 607

  Fly   820 CPHCWRSFVVQPSLDKHIRDMHVAKKNPGKKYLCSLCGLESLTPNKLNIHMRRHTGEKPFKCDLC 884
            |..|..||:...||.:| :.:|..:    |.|.|..|.:..|..:.|..|.:.||||||:||..|
Mouse   608 CKDCGISFLWISSLRRH-QKIHTGE----KPYKCKDCDISFLWISNLRTHQKIHTGEKPYKCQEC 667

  Fly   885 DMRFTVHYELKVHRRKHTGERPYQCTFCDKDFARPDKLRRHVFMH 929
            :..||....|:||:|.|:||:.|:|..||..|.....||||..:|
Mouse   668 NKSFTRCSYLRVHQRTHSGEKLYKCENCDVSFMWISNLRRHQKIH 712

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10669	NP_001163728.1	zf-AD	4..81	CDD:285071
		C2H2 Zn finger	178..199	CDD:275368	7/22 (32%)
		C2H2 Zn finger	216..233	CDD:275368	2/26 (8%)
		C2H2 Zn finger	520..542	CDD:275368	7/25 (28%)
		C2H2 Zn finger	550..570	CDD:275368	8/19 (42%)
		C2H2 Zn finger	579..600	CDD:275368	4/20 (20%)
		C2H2 Zn finger	610..630	CDD:275368	0/19 (0%)
		C2H2 Zn finger	716..737	CDD:275368	6/20 (30%)
		C2H2 Zn finger	746..766	CDD:275368	5/21 (24%)
		C2H2 Zn finger	776..795	CDD:275368	5/18 (28%)
		C2H2 Zn finger	820..838	CDD:275368	7/17 (41%)
		C2H2 Zn finger	853..873	CDD:275368	5/19 (26%)
		zf-H2C2_2	866..889	CDD:290200	11/22 (50%)
		COG5048	877..>930	CDD:227381	24/53 (45%)
		C2H2 Zn finger	881..901	CDD:275368	8/19 (42%)
		zf-H2C2_2	893..918	CDD:290200	12/24 (50%)
		C2H2 Zn finger	909..929	CDD:275368	8/19 (42%)
Zfp52	NP_653098.2	KRAB	12..52	CDD:366587	6/24 (25%)
		C2H2 Zn finger	134..153	CDD:275368	2/18 (11%)
		COG5048	184..615	CDD:227381	130/606 (21%)
		C2H2 Zn finger	188..208	CDD:275368	5/34 (15%)
		C2H2 Zn finger	216..264	CDD:275368	17/68 (25%)
		C2H2 Zn finger	244..259	CDD:275368	4/16 (25%)
		C2H2 Zn finger	272..292	CDD:275368	7/19 (37%)
		C2H2 Zn finger	300..320	CDD:275368	7/42 (17%)
		C2H2 Zn finger	329..348	CDD:275368	4/19 (21%)
		C2H2 Zn finger	357..376	CDD:275368	1/18 (6%)
		C2H2 Zn finger	384..404	CDD:275368	7/23 (30%)
		C2H2 Zn finger	412..432	CDD:275368	6/19 (32%)
		C2H2 Zn finger	440..460	CDD:275368	8/19 (42%)
		C2H2 Zn finger	468..488	CDD:275368	7/70 (10%)
		C2H2 Zn finger	496..516	CDD:275368	9/49 (18%)
		C2H2 Zn finger	524..544	CDD:275368	6/20 (30%)
		C2H2 Zn finger	552..572	CDD:275368	5/19 (26%)
		C2H2 Zn finger	580..600	CDD:275368	5/19 (26%)
		C2H2 Zn finger	608..628	CDD:275368	7/20 (35%)
		zf-H2C2_2	620..643	CDD:372612	8/27 (30%)
		C2H2 Zn finger	636..656	CDD:275368	5/19 (26%)
		zf-H2C2_2	648..673	CDD:372612	12/24 (50%)
		C2H2 Zn finger	664..684	CDD:275368	8/19 (42%)
		zf-H2C2_5	690..714	CDD:372805	10/23 (43%)
		C2H2 Zn finger	692..712	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833381
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.030