DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10669 and ZNF485

DIOPT Version :9

Sequence 1:	NP_001163728.1	Gene:	CG10669 / 43069	FlyBaseID:	FBgn0039329	Length:	933	Species:	Drosophila melanogaster
Sequence 2:	NP_001305069.1	Gene:	ZNF485 / 220992	HGNCID:	23440	Length:	441	Species:	Homo sapiens

Alignment Length:	615	Identity:	135/615 - (21%)
Similarity:	208/615 - (33%)	Gaps:	208/615 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   320 IKHKHKEHLDKESYKQSDDEDDRPLASTSASASAPTAKPSRINRRVDGFDFHRSEPNGAKEIKCM 384
            |:.:|.:...:..|:....|:...|.|....:|    ||..|.:...|     :||
Human    23 IEWRHLDAAQRALYRDVMLENYGNLVSVGLLSS----KPKLITQLEQG-----AEP--------- 69

  Fly   385 ICLRRFTKLRELRNHLQNHPT-DFDFEAHGEPIERIAEGFFKTAVESTAEGLKRRIFRDLRMGVY 448
                 :|::||..:  ..|.. |:.||.....::           :||:|.           .|.
Human    70 -----WTEVREAPS--GTHAVEDYWFETKMSALK-----------QSTSEA-----------SVL 105

  Fly   449 GRYYSITNQARYEMTLDSSDTDSDGDGDDNVVIRRSYSCELCDSPEARWPRKYLLHQHHQKEHTW 513
            |..   |.....|..||.....|         ..::|.|:.| ....::...::   .||:.||
Human   106 GER---TKSVMMEKGLDWEGRSS---------TEKNYKCKEC-GKVFKYNSSFI---SHQRNHT- 153

  Fly   514 LDAPHVCQRCDSRFLN-LQLLKHHTSQLCQNTLKRFMCDKCPQRFFWRRNLRAHLVEHKCKQESY 577
            .:.||.|:.|...|:| ..||.||                           :.|     ..::.|
Human   154 SEKPHKCKECGIAFMNSSSLLNHH---------------------------KVH-----AGKQPY 186

  Fly   578 PCDQCSRSFQDKSAVTKHKLMMHRDSNMELLPCRWCTRTFYRPALLYKHLQRHGFTGQDLPLAET 642
            .|.:|.:..:..|....|:.:..|:...:   |..|.:||.:.::|..|.:.|  |||
Human   187 RCIECGKFLKKHSTFINHQRIHSREKPHK---CIECGKTFRKNSILLSHQRIH--TGQ------- 239

  Fly   643 LLADASKPAGPKSVQCKICDIQFVSVADLRRHISMQGHSDQPSAYMISTATGFELLLDDTDDSDE 707
                       |..:|..|...|...|.|.||..:  ||.:
Human   240 -----------KPYKCNDCGKAFAQNAALTRHERI--HSGE------------------------ 267

  Fly   708 ETSGRTYSCDLCDLNFRRRREISEHQYSLHSFDKLPHNCEHC--IFKTVDKNMLHQHLRTQCMNT 770
                :.:.|:.|...||....:.||| .:|:.:| |:.|..|  .|:.....:.||.:.|    .
Human   268 ----KPFKCNKCGRAFRDNSTVLEHQ-KIHTGEK-PYQCNECGKAFRKSSTLISHQRMHT----G 322

  Fly   771 EKKFACMRCGYKFMWEENLAQHLSTQHSKQPAVPEQQPPLRRKRRFRYQCPHCWRSFVVQPSLDK 835
            ||.:.|.:||..|.:..:.|.|..|....:|                |||..|.::|....:|..
Human   323 EKPYHCSKCGKSFRYSSSFAGHQKTHSGNKP----------------YQCRDCGKAFTKSSTLTG 371

  Fly   836 HIRDMHVAKKNPGKKYLCSLCGLESLTPNKLNIHMRRHTGEKPFKCDLCDMRFTVHYELKVHRRK 900
                                             |.|.||||||:.|..|...|.....|..|:|.
Human   372 ---------------------------------HQRIHTGEKPYHCKKCGKAFRHSSGLVEHQRL 403

  Fly   901 HTGERPYQCTFCDKDFARPDKLRRHVFMHN 930
            ||||:||:|..|.|.|.|...|::|..:||
Human   404 HTGEKPYKCNECGKAFPRSSALKQHKKIHN 433

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10669	NP_001163728.1	zf-AD	4..81	CDD:285071
		C2H2 Zn finger	178..199	CDD:275368
		C2H2 Zn finger	216..233	CDD:275368
		C2H2 Zn finger	520..542	CDD:275368	8/22 (36%)
		C2H2 Zn finger	550..570	CDD:275368	1/19 (5%)
		C2H2 Zn finger	579..600	CDD:275368	4/20 (20%)
		C2H2 Zn finger	610..630	CDD:275368	6/19 (32%)
		C2H2 Zn finger	716..737	CDD:275368	7/20 (35%)
		C2H2 Zn finger	746..766	CDD:275368	5/21 (24%)
		C2H2 Zn finger	776..795	CDD:275368	6/18 (33%)
		C2H2 Zn finger	820..838	CDD:275368	4/17 (24%)
		C2H2 Zn finger	853..873	CDD:275368	2/19 (11%)
		zf-H2C2_2	866..889	CDD:290200	10/22 (45%)
		COG5048	877..>930	CDD:227381	21/52 (40%)
		C2H2 Zn finger	881..901	CDD:275368	6/19 (32%)
		zf-H2C2_2	893..918	CDD:290200	13/24 (54%)
		C2H2 Zn finger	909..929	CDD:275368	7/19 (37%)
ZNF485	NP_001305069.1	KRAB	11..71	CDD:214630	13/70 (19%)
		KRAB	11..50	CDD:279668	5/26 (19%)
		COG5048	<124..361	CDD:227381	75/357 (21%)
		C2H2 Zn finger	132..152	CDD:275368	4/23 (17%)
		C2H2 Zn finger	160..180	CDD:275368	8/46 (17%)
		C2H2 Zn finger	188..208	CDD:275368	4/19 (21%)
		C2H2 Zn finger	216..236	CDD:275368	6/19 (32%)
		zf-H2C2_2	229..253	CDD:290200	10/43 (23%)
		C2H2 Zn finger	244..264	CDD:275368	7/21 (33%)
		zf-H2C2_2	256..279	CDD:290200	7/52 (13%)
		C2H2 Zn finger	272..292	CDD:275368	7/20 (35%)
		zf-H2C2_2	287..307	CDD:290200	8/21 (38%)
		C2H2 Zn finger	300..320	CDD:275368	5/19 (26%)
		zf-H2C2_2	313..337	CDD:290200	9/27 (33%)
		C2H2 Zn finger	328..348	CDD:275368	6/19 (32%)
		C2H2 Zn finger	356..376	CDD:275368	6/52 (12%)
		zf-H2C2_2	372..393	CDD:290200	11/20 (55%)
		C2H2 Zn finger	384..404	CDD:275368	6/19 (32%)
		zf-H2C2_2	397..419	CDD:290200	12/21 (57%)
		C2H2 Zn finger	412..432	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143214
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930