DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10669 and Zfp729a

DIOPT Version :9

Sequence 1:	NP_001163728.1	Gene:	CG10669 / 43069	FlyBaseID:	FBgn0039329	Length:	933	Species:	Drosophila melanogaster
Sequence 2:	NP_898969.2	Gene:	Zfp729a / 212281	MGIID:	3036250	Length:	973	Species:	Mus musculus

Alignment Length:	1033	Identity:	238/1033 - (23%)
Similarity:	378/1033 - (36%)	Gaps:	304/1033 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 VEKYAEKTFV-------QLLVELTRIE----------VVMAQAEKFPQWLCYACAE---KLESTY 65
            :|.|:...|:       .|:..|.:|:          ..|.:.||     ||.|.|   ..|.|.
Mouse    45 LENYSNLVFLGLASCKPHLITCLEQIQEPSDVKRGAATSMLRGEK-----CYTCKECGKVFEWTK 104

  Fly    66 DFVLQARRTHELWLQKIGDSLNGDDEMEGTAALECLRETPIHLFEIEGVTIKTEELASTQQAPKA 130
            .|     :.||:..  ||        |......||.|.     |....::.:...:.:.::..|.
Mouse   105 VF-----QNHEMLY--IG--------MNPNKCEECARS-----FHSPSLSSEENRIHTGEKPYKC 149

  Fly   131 D--------PLVRPRIVKRSIVHFSDSDEDLDDVPLRQRKIAASVCGS---------------DT 172
            :        ||:   :.|...||   :.|:|         ....|||.               ..
Mouse   150 EVCGKAFCIPLL---LSKHKRVH---TGENL---------YKCEVCGKAFQHPSRLSRHKKIHSE 199

  Fly   173 TKENVCELCNKVFRYVTNLYRHKQRDHGILGKNGEDYEEDYYKCDLCDKTYKYVMALVKHKHKE- 236
            .|...||:|.|.|.:.:.|..||:...|          |..|||::|||.:.|...|.|||...
Mouse   200 EKPYKCEVCGKAFHFPSLLLVHKRVHTG----------EKPYKCEICDKAFHYPSILSKHKRIHT 254

  Fly   237 --------------HGSSLLSNNS----GRKMPSTLAEDANPYSPASISETSTNQSRTNNDSLVH 283
                          |.||.||.:.    |.|          ||......:.....||.:|...:
Mouse   255 GEKPYKCEECGKAFHISSFLSKHKIIHRGEK----------PYKCEVCGKAFHYPSRLSNHKKI- 308

  Fly   284 SIIKAVVLSDEDGHSGEDSYYNCDQCSKSYKYIVSLIKHKHKEHLDKESYK-----QSDDEDDRP 343
                         ||||.. :.|:.|.|:::.:..|.||| ..|.::..||     ::.|
Mouse   309 -------------HSGEKP-FKCEVCGKAFRILSLLSKHK-IIHTEENPYKCEVCGKAFD----- 353

  Fly   344 LASTSASASAPTAKPSRINRRVDGFDFHRSEPNGAKEIKCMICLRRFTKLRELRNHLQNHPTD-- 406
                         .|||::.       |.....|.|..||.:|.:.|..|..|..|.:.|..|
Mouse   354 -------------YPSRLST-------HAKMHTGEKPYKCEVCQKAFRSLSSLSKHKRIHTEDNY 398

  Fly   407 FDFEAHGEPI---------ERIAEGFFKTAVESTAEGLKRRIFRDLRMGVYGRYYSITNQARYEM 462
            ::.|..|:..         :||..|                 .:..:..|.|:.:.:::......
Mouse   399 YNNELCGKAFIYPSRLSKHKRICAG-----------------EKPYKCEVCGKAFHVSSLLSKHR 446

  Fly   463 TLDSSDTDSDGDGDDNVVIRRSYSCELCDSPEARWPRKYLLHQ---------------------- 505
            |:.:.:              :.|.||:| .....:|.:...|:
Mouse   447 TIHTGE--------------KLYKCEVC-GKAFYYPSRLSNHKKIHTGEKPFQCEVCGKAFCFPS 496

  Fly   506 ---HHQKEHTWLDAPHVCQRCDSRFLNL-QLLKH---HTSQLCQNTLKRFMCDKCPQRFFWRRNL 563
               .|::.||. :.|:.|:.|...|.:| .|.||   ||.:      |.:.|::|.:.|.:...|
Mouse   497 SLSKHKRIHTG-EKPYKCKECGKAFRSLSSLSKHKRIHTGE------KPYKCEECGKAFHYPSLL 554

  Fly   564 RAHLVEHKCKQESYPCDQCSRSFQDKSAVTKHKLMMHRDSNMELLPCRWCTRTFYRPALLYKHLQ 628
            ..|.:.| .:::.|.||.|.::|...|.::.||::   .:..:...|..|.:.|..|.||.||.:
Mouse   555 SKHKIIH-TEEKPYKCDVCGQAFHVPSKLSHHKII---HTGEKPYKCEVCGKAFCIPLLLSKHKR 615

  Fly   629 RHGFTGQDLPLAETLLADASKPAGPKSVQCKICDIQFVSVADLRRHISMQGHSDQPSAYMISTAT 693
            .|  ||::                |.:.|  :|...||..:.|.:|..::.........:...|.
Mouse   616 VH--TGEN----------------PYNSQ--VCSKAFVYPSKLSKHKKVRTKEKPYKCEVCGKAF 660

  Fly   694 GFELLLDDTDDSDEETSGRTYSCDLCDLNFRRRREISEHQYSLHSFDKLPHNCEHC-----IFKT 753
            .|..||  .......|..:.|.|:.|...|.....:|:|: .:|:.:| |:.||.|     :..:
Mouse   661 RFPSLL--LIHKGMHTGEKPYKCEDCGKAFHYPSLLSKHK-RIHTGEK-PYQCEVCGKDFHVSSS 721

  Fly   754 VDKNMLHQHLRTQCMNTEKKFACMRCGYKFMWEENLAQHLSTQHSKQPAVPEQ------QPPLRR 812
            :.|   |:.:.|    .||.:.|..||..|.:..:|::|......|:|...|:      .|.:..
Mouse   722 LSK---HRIIHT----GEKPYKCEICGKTFRFSSSLSKHKRNHTGKKPYKCEECGKAFHFPSILA 779

  Fly   813 KRRFR------YQCPHCWRSFVVQPSLDKHIRDMHVAKKNPGKKYLCSLCGLESLTPNKLNIHMR 871
            |.:..      |.|..|.::|.....|.|| :.:|..:| |.|   |.:||.....|:||:.|.:
Mouse   780 KHKISHTGEKPYNCDLCGKAFHYASLLSKH-KMIHTGEK-PHK---CDICGKAFHYPSKLSNHKK 839

  Fly   872 RHTGEKPFKCDLCDMRFTVHYELKVHRRKHTGERPYQCTFCDKDFARPDKLRRHVFMH 929
            .||||||:||::|...|.....|..|:|.||||.||:|..|.|.|..|..|.:|..:|
Mouse   840 IHTGEKPYKCEVCGNVFCFASSLSKHKRIHTGENPYKCEVCGKAFYYPSLLSKHKIIH 897

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10669	NP_001163728.1	zf-AD	4..81	CDD:285071	18/79 (23%)
		C2H2 Zn finger	178..199	CDD:275368	8/20 (40%)
		C2H2 Zn finger	216..233	CDD:275368	7/16 (44%)
		C2H2 Zn finger	520..542	CDD:275368	9/25 (36%)
		C2H2 Zn finger	550..570	CDD:275368	5/19 (26%)
		C2H2 Zn finger	579..600	CDD:275368	7/20 (35%)
		C2H2 Zn finger	610..630	CDD:275368	8/19 (42%)
		C2H2 Zn finger	716..737	CDD:275368	5/20 (25%)
		C2H2 Zn finger	746..766	CDD:275368	5/24 (21%)
		C2H2 Zn finger	776..795	CDD:275368	6/18 (33%)
		C2H2 Zn finger	820..838	CDD:275368	6/17 (35%)
		C2H2 Zn finger	853..873	CDD:275368	7/19 (37%)
		zf-H2C2_2	866..889	CDD:290200	11/22 (50%)
		COG5048	877..>930	CDD:227381	23/53 (43%)
		C2H2 Zn finger	881..901	CDD:275368	6/19 (32%)
		zf-H2C2_2	893..918	CDD:290200	13/24 (54%)
		C2H2 Zn finger	909..929	CDD:275368	7/19 (37%)
Zfp729a	NP_898969.2	KRAB	15..73	CDD:214630	6/27 (22%)
		KRAB	15..54	CDD:279668	2/8 (25%)
		C2H2 Zn finger	93..110	CDD:275368	5/21 (24%)
		C2H2 Zn finger	121..141	CDD:275368	4/24 (17%)
		C2H2 Zn finger	149..169	CDD:275368	3/22 (14%)
		C2H2 Zn finger	177..197	CDD:275368	3/19 (16%)
		zf-H2C2_2	190..213	CDD:290200	5/22 (23%)
		C2H2 Zn finger	205..225	CDD:275368	8/19 (42%)
		zf-H2C2_2	218..242	CDD:290200	11/33 (33%)
		COG5048	229..670	CDD:227381	117/556 (21%)
		C2H2 Zn finger	233..253	CDD:275368	9/19 (47%)
		zf-H2C2_2	246..269	CDD:290200	4/22 (18%)
		C2H2 Zn finger	261..281	CDD:275368	5/19 (26%)
		C2H2 Zn finger	289..309	CDD:275368	3/33 (9%)
		zf-H2C2_2	302..324	CDD:290200	8/36 (22%)
		C2H2 Zn finger	317..337	CDD:275368	7/20 (35%)
		C2H2 Zn finger	345..365	CDD:275368	5/44 (11%)
		C2H2 Zn finger	373..393	CDD:275368	6/19 (32%)
		C2H2 Zn finger	404..421	CDD:275368	2/16 (13%)
		C2H2 Zn finger	429..449	CDD:275368	3/19 (16%)
		C2H2 Zn finger	457..477	CDD:275368	5/20 (25%)
		zf-H2C2_2	470..492	CDD:290200	1/21 (5%)
		C2H2 Zn finger	485..505	CDD:275368	1/19 (5%)
		zf-H2C2_2	497..522	CDD:290200	7/25 (28%)
		COG5048	509..951	CDD:227381	121/435 (28%)
		C2H2 Zn finger	513..533	CDD:275368	7/19 (37%)
		zf-H2C2_2	525..550	CDD:290200	9/30 (30%)
		C2H2 Zn finger	541..561	CDD:275368	5/19 (26%)
		C2H2 Zn finger	569..589	CDD:275368	7/22 (32%)
		C2H2 Zn finger	597..617	CDD:275368	8/19 (42%)
		C2H2 Zn finger	626..645	CDD:275368	6/20 (30%)
		C2H2 Zn finger	653..673	CDD:275368	4/21 (19%)
		C2H2 Zn finger	681..701	CDD:275368	5/20 (25%)
		zf-H2C2_2	694..717	CDD:290200	8/24 (33%)
		C2H2 Zn finger	709..729	CDD:275368	5/22 (23%)
		zf-H2C2_2	721..744	CDD:290200	8/29 (28%)
		C2H2 Zn finger	737..757	CDD:275368	6/19 (32%)
		zf-H2C2_2	749..773	CDD:290200	5/23 (22%)
		C2H2 Zn finger	765..785	CDD:275368	3/19 (16%)
		C2H2 Zn finger	793..813	CDD:275368	6/20 (30%)
		zf-H2C2_2	806..830	CDD:290200	10/28 (36%)
		C2H2 Zn finger	821..841	CDD:275368	7/19 (37%)
		C2H2 Zn finger	849..869	CDD:275368	6/19 (32%)
		zf-H2C2_2	861..886	CDD:290200	13/24 (54%)
		C2H2 Zn finger	877..897	CDD:275368	7/19 (37%)
		zf-H2C2_2	890..914	CDD:290200	3/8 (38%)
		C2H2 Zn finger	905..925	CDD:275368
		C2H2 Zn finger	933..953	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010